Research Interests
Key words: genetics of brain structure and development, neural progenitor cell models, computational biology
We are a lab exploring how variations in the genome change the structure and development of the brain, and in doing so, create risk for neuropsychiatric illness. We study genetic effects on multiple aspects of the human brain, from macroscale phenotypes like gross human brain structure measured with MRI to molecular phenotypes like gene expression and chromatin accessibility measured with genome-sequencing technologies. We also use neural progenitor cells as a modifiable and high fidelity model system to understand how disease-associated variants affect brain development.
Mentor Training:
- Bias 101
- Faculty Mentoring Workshop for Biomedical Researchers
Training Program Affiliations:
- Bioinformatics and Computational Biology
- Genetics and Molecular Biology
- Neuroscience
Publications
Lab Members
If you are a grad student interested in a lab rotation, please email me. If you are interested in a postdoc in my lab, please email me with a cover letter and CV containing contact information for at least 3 references.
Jason Stein in UNC Genetics News
October 28, 2024
Department of Genetics Publications for October 13th – 26th, 2024
Department of Genetics faculty, postdocs, students and collaborators published 13 papers during October 13th - 26th, 2024.
October 23, 2024
Researchers help decode risk for psychiatric disorders
Jason Stein’s lab in the UNC School of Medicine created a model to identify genetic variants linked to mental illness.
October 17, 2024
Department of Genetics Publications for September 29th – October 12th, 2024
Department of Genetics faculty, postdocs, students and collaborators published 13 papers during September 29th - October 12th, 2024.
September 27, 2024
Jason Stein Awarded New U01 Grant from NIA
Dr. Jason Stein (Associate Professor, Genetics and Neuroscience Center) was awarded a new U01 grant from the National Institute of Aging (NIA) for his project titled “AD GxE: in vivo and in vitro modeling of gene x environment interactions”.
September 1, 2024
Department of Genetics Publications for August 18th – 31st, 2024
Department of Genetics faculty, postdocs, students and collaborators published 18 papers during August 18th - 31st 2024.
July 24, 2024
Department of Genetics Publications for July 7th – 20th, 2024
Department of Genetics faculty, postdocs, students and collaborators published 16 papers during July 7th - 20th 2024.
June 10, 2024
Department of Genetics Publications for May 12th – June 8th, 2024
Department of Genetics faculty, postdocs, students and collaborators published 23 papers during May 12th - June 8th 2024.
May 13, 2024
Department of Genetics Publications for April 28th – May 11th, 2024
Department of Genetics faculty, postdocs, students and collaborators published 11 papers during April 28th - May 11th 2024.
March 22, 2024
Dr. Jason Stein Awarded SBIR from Ramona Optics
Jason Stein, PhD (Associate Professor, Genetics and Neuroscience Center) has been awarded a Small Business Innovation Research (SBIR) Award from Ramona Optics for his project titled “A parallelized imaging platform for accurate and efficient long-term assessment of organoid growth”.
January 25, 2024
Dr. Jason Stein Awarded NCBC “Flash Grant”
Jason Stein, PhD (Associate Professor, Department of Genetics) was awarded a “Flash Grant” from the North Carolina Biotechnology Center for his project titled “HotPockets: Novel devices for non-destructive, long-term electrophysiological recording and stimulation of entire human brain organoids”.
