Key words: genetics of brain structure and development, neural progenitor cell models, computational biology
We are a lab exploring how variations in the genome change the structure and development of the brain, and in doing so, create risk for neuropsychiatric illness. We study genetic effects on multiple aspects of the human brain, from macroscale phenotypes like gross human brain structure measured with MRI to molecular phenotypes like gene expression and chromatin accessibility measured with genome-sequencing technologies. We also use neural progenitor cells as a modifiable and high fidelity model system to understand how disease-associated variants affect brain development.
- Bias 101
- Faculty Mentoring Workshop for Biomedical Researchers
Training Program Affiliations:
- Bioinformatics and Computational Biology
- Genetics and Molecular Biology
If you are a grad student interested in a lab rotation, please email me. If you are interested in a postdoc in my lab, please email me with a cover letter and CV containing contact information for at least 3 references.
Jason Stein in UNC Genetics News
April 12, 2022
Li, Stein and Zhu Labs Publish Paper in Nature Genetics
The laboratories of Drs. Yun Li (Professor, Genetics), Jason Stein (Associate Professor, Genetics) and Hongtu Zhu (Professor, Computer Science and Genetics) published a paper titled “Common variants contribute to intrinsic human brain functional networks” in Nature Genetics 2022 Apr 7.
April 11, 2022
Department of Genetics Publications March 27th – April 9th, 2022
Department of Genetics faculty, postdocs, students and collaborators published 17 papers during March 27th – April 9th, 2022.
January 6, 2022
Graduate Students Sarah Brotman (GMB) and Brandon Le (BCB) Participate in 2021 “Shadow a Scientist” Program
Sarah Brotman (GMB – Mohlke lab) and Brandon Le (BCB – Stein lab) participated (virtually) in the 2021 UNC “Shadow a Scientist” Program.
January 3, 2022
Jason Stein, PhD Promoted to Associate Professor
Dr. Jason Stein has been promoted to Associate Professor with tenure in the Department of Genetics, effective January 1, 2022.
January 3, 2022
Stein and Zannas Awarded NeuroSpark Pilot Grants
As part of the Forward Together Strategic Plan, the UNC School of Medicine committed $100,000 this year to fund pilot neuroscience research projects through the NeuroSpark event.
October 18, 2021
Department of Genetics Publications October 3rd – 16th 2021
Department of Genetics faculty, postdocs, students and collaborators published 11 papers during October 3rd – 16th 2021.
August 23, 2021
Department of Genetics Publications August 8th – 21st, 2021
Department of Genetics faculty, postdocs, students and collaborators published 18 papers during August 8th – 21st, 2021.
August 19, 2021
Stein Lab Publishes in American Journal of Human Genetics
The laboratory of Dr. Jason Stein (Assistant Professor, Genetics and Neuroscience Center) published a paper titled “Brain-trait-associated variants impact cell-type specific gene regulation during neurogenesis” in the American Journal of Human Genetics (19 Aug 2021 issue).
July 30, 2021
Jason Stein, PhD and Hyejung Won, PhD Awarded U01 Grant from NIMH
Drs. Jason Stein (Assistant Professor) and Hyejung Won (Assistant Professor) have been awarded an U01 grant from the National Institutes of Mental Health (NIMH) for their project titled “Discovery and validation of genetic variation impacting the gene regulatory landscape during human cortical development”.
June 28, 2021
Department of Genetics Publications for June 13-26, 2021
Department of Genetics faculty, postdocs, students and collaborators published twenty one papers during June 13-26, 2021.