Research Interests
Key words: genetics of brain structure and development, neural progenitor cell models, computational biology
We are a lab exploring how variations in the genome change the structure and development of the brain, and in doing so, create risk for neuropsychiatric illness. We study genetic effects on multiple aspects of the human brain, from macroscale phenotypes like gross human brain structure measured with MRI to molecular phenotypes like gene expression and chromatin accessibility measured with genome-sequencing technologies. We also use neural progenitor cells as a modifiable and high fidelity model system to understand how disease-associated variants affect brain development.
Mentor Training:
- Bias 101
- Faculty Mentoring Workshop for Biomedical Researchers
Training Program Affiliations:
- Bioinformatics and Computational Biology
- Genetics and Molecular Biology
- Neuroscience
Publications
Lab Members
If you are a grad student interested in a lab rotation, please email me. If you are interested in a postdoc in my lab, please email me with a cover letter and CV containing contact information for at least 3 references.
Jason Stein in UNC Genetics News
October 18, 2021
Department of Genetics Publications October 3rd – 16th 2021
Department of Genetics faculty, postdocs, students and collaborators published 11 papers during October 3rd – 16th 2021.
August 23, 2021
Department of Genetics Publications August 8th – 21st, 2021
Department of Genetics faculty, postdocs, students and collaborators published 18 papers during August 8th – 21st, 2021.
August 19, 2021
Stein Lab Publishes in American Journal of Human Genetics
The laboratory of Dr. Jason Stein (Assistant Professor, Genetics and Neuroscience Center) published a paper titled “Brain-trait-associated variants impact cell-type specific gene regulation during neurogenesis” in the American Journal of Human Genetics (19 Aug 2021 issue).
July 30, 2021
Jason Stein, PhD and Hyejung Won, PhD Awarded U01 Grant from NIMH
Drs. Jason Stein (Assistant Professor) and Hyejung Won (Assistant Professor) have been awarded an U01 grant from the National Institutes of Mental Health (NIMH) for their project titled “Discovery and validation of genetic variation impacting the gene regulatory landscape during human cortical development”.
June 28, 2021
Department of Genetics Publications for June 13-26, 2021
Department of Genetics faculty, postdocs, students and collaborators published twenty one papers during June 13-26, 2021.
May 29, 2021
Department of Genetics Publications for May 16-29, 2021
Department of Genetics faculty, postdocs, students and collaborators published nineteen papers during May 16-29, 2021.
May 20, 2021
Stein Lab Publishes Paper in Nature Neuroscience
Dr. Jason Stein (Assistant Professor, Department of Genetics) and colleagues have published a manuscript in Nature Neuroscience (20 May 2021) titled “Cell-type specific effects of genetic variation on chromatin accessibility during human neuronal differentiation”.
May 2, 2021
Department of Genetics Publications for April 18 – May 1, 2021
Department of Genetics faculty, postdocs, students and collaborators published thirteen papers during April 18 – May 1, 2021.
December 14, 2020
Department of Genetics Publications for Nov. 29 – Dec. 12, 2020
Department of Genetics faculty, postdocs, students and collaborators published ten papers during November 29 – December 12, 2020.
November 2, 2020
Department of Genetics Publications for October 11-31, 2020
Department of Genetics faculty, postdocs, students and collaborators published 18 papers during October 11-31, 2020. Survival, Pathologic Response, and Genomics in CALGB 40601 (Alliance), a Neoadjuvant Phase III Trial of Paclitaxel-Trastuzumab With or Without Lapatinib in HER2-Positive Breast Cancer. Fernandez-Martinez A, Krop IE, Hillman DW, Polley MY, Parker JS, Huebner L, Hoadley KA, …
