Evans and Perou are quoted regarding the risks of reporting germline mutations in numerous genes implicated in rare forms of hereditary predispositions to breast cancer.
Chuck points out that there are probably 10 – 100 genes in addition to BRCA1 and BRCA2 that may contribute to breast cancer susceptibility. Both he and Jim argue for exercising caution in providing patients with results that so far are ambiguous regarding increased risk, even though it is currently possible to screen for them.
Read the article, which is entitled “The ‘Other’ Breast Cancer Genes,” in Science.
Read the Lineberger Center article.