Researchers from the Raffield lab, as well as Raffield lab collaborators from the Li lab group had presentations or posters at the American Society for Human Genetics annual meeting (Nov. 1-5 2023). Brian Chen held his oral presentation Proteome-Wide Association Study Using Cis and Trans Variants and Applied to Blood Cell and Lipid-Related Traits in … Read more
Katherine was awarded the Biostatistics Undergraduate Summer Internships (BUSI) Program End-of-Summer Research Symposium Best Poster Award for her poster Cross-Platform Comparison of Type 2 Diabetes Proteomic Signatures in the Jackson Heart Study. This award is given annually to most accomplished poster presentations at the symposium.
Madeline Gillman was appointed to the Bioinformatics and Computational Biology (BCB) T32 Training Grant. Her proposal focused on QTLs for longitudinal ‘omic trajectory measures in TOPMed. Congratulations, Madeline!
CCA is a correlation-based method for multi-omics data which reduces the dimension of each omic assay to several orthogonal components–commonly referred to as canonical variables (CVs). The widely-used SMCCA method allows effective dimension reduction and integration of multi-omics data, but suffers from potentially highly correlated CVs when applied to high-dimensional omics data. Here, we improve the statistical independence among the CVs by adopting a variation of the GS algorithm. We applied our SMCCA-GS method to proteomic and methylomic data from two cohort studies, MESA and JHS.
Emily Drzymalla presented the poster “Association between neutrophil to lymphocyte ratio and Alzheimer’s disease (AD) in large biobank cohorts” at the Alzheimer’s Association International Conference (AAIC) meeting in Amsterdam July 19, 2023. We look forward to sharing a manuscript describing these findings soon!
Le Huang presented the poster “Metabolite prediction models in UK Biobank: A metabolome-wide association study (MWAS)“ at the American Society of Human Genetics (ASHG) meeting in Los Angeles, Oct, 2022. We look forward to sharing a manuscript describing these findings soon.
With many collaborators from TOPMed, the Raffield lab was pleased to contribute to recent whole genome sequencing based publications for red blood cell, white blood cell, and platelet related traits. These publications identified novel single variant signals for these heritable hematological measures, despite the 10x smaller sample size versus existing analyses of imputed genotyped data … Read more
Jayna Nicholas was appointed to the Genetics and Molecular Biology (GMB) T32 Training Grant. Her proposal focused on improved understanding of discordant pQTLs across proteomics platforms in diverse cohort studies from TOPMed. Congratulations, Jayna!
Platelets play a key role in thrombosis and hemostasis. Platelet count (PLT) and mean platelet volume (MPV) are highly heritable quantitative traits, with hundreds of genetic signals previously identified, mostly in European ancestry populations. We here utilize whole genome sequencing (WGS) from NHLBI’s Trans-Omics for Precision Medicine initiative (TOPMed) in a large multi-ethnic sample to further explore common and rare variation contributing to PLT (n = 61 200) and MPV (n = 23 485).
Sarthi Patil was awarded the Biostatistics Undergraduate Summer Internships (BUSI) Program End-of-Summer Research Symposium Best Poster Presentation Award for her poster entitled TWAS Training for Jackson Heart Study Cohort. Sarthi is working to train transcriptome-wide association study (TWAS) models using newly generated RNA-seq data from the Jackson Heart Study. Congratulations, Sarthi!