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PERSONAL WEBSITE:
http://www.uncnri.org/index.php/stephen-hursting-ph-d-m-p-h/ |
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Dr. Hursting’s lab focuses on the molecular and metabolic mechanisms underlying nutrition and cancer associations, particularly the impact of obesity and energy balance modulation (eg, calorie restriction, exercise) on cancer development or responses to chemotherapy. Primarily using genetically engineered mouse models of pancreatic, colon and breast cancer, Dr. Hursting has identified the IGF-1/Akt/mTOR and NF-kB signaling pathways as key targets for breaking the obesity- cancer link. He has also established in several preclinical models of pancreatic and breast cancer that obesity impacts the response to various forms of chemotherapy. In addition, the Hursting lab is involved in several translational research collaborations linking mouse model studies with clinical trials, and his group has expertise in measuring metabolic hormones, growth factors, inflammatory cytokines and chemokines in serum and tissue from rodents and humans.,Dr. Hursting’s lab focuses on the molecular and metabolic mechanisms underlying nutrition and cancer associations, particularly the impact of obesity and energy balance modulation (eg, calorie restriction, exercise) on cancer development or responses to chemotherapy. Primarily using genetically engineered mouse models of pancreatic, colon and breast cancer, Dr. Hursting has identified the IGF-1/Akt/mTOR and NF-kB signaling pathways as key targets for breaking the obesity- cancer link. He has also established in several preclinical models of pancreatic and breast cancer that obesity impacts the response to various forms of chemotherapy. In addition, the Hursting lab is involved in several translational research collaborations linking mouse model studies with clinical trials, and his group has expertise in measuring metabolic hormones, growth factors, inflammatory cytokines and chemokines in serum and tissue from rodents and humans.
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CLINICAL/RESEARCH INTERESTS:
Biochemistry, Cancer Biology, Cell Signaling, Metabolism, Physiology |