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Our research focuses on the discovery and design of new gene-encoded bioactive small molecules from bacteria. We are interested in understanding enzymes involved in their biosynthesis, their therapeutic mechanisms of action, and implications in health and diseases, in particular with respect to the human microbiome. This work is driven by intensive development of new metabolomics and genomics technologies. We subsequently manipulate and engineer these biosynthetic pathways to make new and improved molecules as potential therapeutics such as antibiotics.,Our research focuses on the discovery and design of new gene-encoded bioactive small molecules from bacteria. We are interested in understanding enzymes involved in their biosynthesis, their therapeutic mechanisms of action, and implications in health and diseases, in particular with respect to the human microbiome. This work is driven by intensive development of new metabolomics and genomics technologies. We subsequently manipulate and engineer these biosynthetic pathways to make new and improved molecules as potential therapeutics such as antibiotics.
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CLINICAL/RESEARCH INTERESTS:
Bacteriology, Biochemistry, Biophysics, Chemical Biology, Molecular Biology |