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The development of metastases is the cause of death in nearly all cancer patients, yet the mechanisms driving metastatic biology remain poorly understood. Also, few cancer therapeutics are being developed to specifically control this problem. My laboratory is interested in discovering novel mechanisms that drive metastatic biology, and in utilizing RNA interference (RNAi) strategies (such as nanoparticle delivery of miRNAs/siRNAs) to control this process. We will apply integrative analysis of large bioinformatic datasets, in vitro studies for mechanistic validation, and in vivo metastasis models to assess therapeutic efficacy of our RNAi approaches.,The development of metastases is the cause of death in nearly all cancer patients, yet the mechanisms driving metastatic biology remain poorly understood. Also, few cancer therapeutics are being developed to specifically control this problem. My laboratory is interested in discovering novel mechanisms that drive metastatic biology, and in utilizing RNA interference (RNAi) strategies (such as nanoparticle delivery of miRNAs/siRNAs) to control this process. We will apply integrative analysis of large bioinformatic datasets, in vitro studies for mechanistic validation, and in vivo metastasis models to assess therapeutic efficacy of our RNAi approaches.
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CLINICAL/RESEARCH INTERESTS:
Bioinformatics, Cancer Biology, Nanomedicine, Pathology, Translational Medicine |