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We use genetic and biochemical approaches and animal models of disease to study how the intestinal pathogen Clostridioides difficile (C. diff) colonizes the intestinal tract and causes disease. We are focused on signal transduction pathways and stochastic bet-hedging strategies used by this bacterium to adapt to the intestinal environment and to regulate the production of virulence factors (flagella, pili, toxins).
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UNC AFFILIATIONS:
Center for GI Biology and Disease (CGIBD), Microbiology & Immunology |
CLINICAL/RESEARCH INTERESTS:
Bacteriology, Gastrointestinal Biology, Genetics, Microbiology, Molecular Biology, Pathogenesis & Infection |