Research
| Mucin Interactome
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Mucus is a strong polymer network. The contributions of mucins and other globular proteins, however, have not yet been fully elucidated. Read more |
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| Spiromics Ancillary
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SPIROMICS, (Subpopulations and intermediate outcome measures in COPD observational study). Our overall hypothesis, based upon our previous and ongoing studies, is that the molecular composition of the mucus and the concentration and macromolecular organization of its mucins are altered in the COPD environment. Read more |
| TCORS Project II
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The Effects of Tobacco Exposure on the Airway Mucus/Mucin Integrity and Proteome: Determining the Tobacco Mucomarkers. Read more |
Exosome-Like Vesicles  |
Our initial studies on the isolation of HTBE mucins and induced sputum indicated that isolated mucin rich fractions contain lipid/carbohydrate/protein rich vesicular/exosomal material. Further fractionation and preliminary proteomics analysis on these fractions revealed proteins characteristic of exosomes. Read More |
| Mucin Unpackaging
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Unpacking a gel forming mucins
Unpacking is a series of post-secretory processing steps that changes the mucin from a granular compact cross-linked form, to an expanded linear form that becomes the basis of the transportable mucus gel. Read More |
