Author Archives: Yinglong Miao

Congratulations to Keya for a first-authored paper published in The Journal of Physical Chemistry B on “Mechanism of Tethered Agonist Binding to an Adhesion G-Protein-Coupled Receptor“! Abstract Adhesion G-protein-coupled receptors (ADGRs) contain a GPCR autoproteolysis-inducing (GAIN) domain that is proximal to the receptor N-terminus and undergoes autoproteolysis at a highly...

Our recent research published in PNAS has been highlighted by UNC Health News: “UNC Scientists Discover How a Critical Signaling Step Works Inside Cells“: “UNC researchers discovered how a key step in cell signaling works by showing exactly how G proteins detach from receptors that many common medicines target. Scientists...

Congratulations to Jinan and Victor for a new paper published in PNAS on “Dissociation kinetics of G proteins from G protein–coupled receptors and effects of allosteric modulation“! Really excited to share this story: The PPI-GaMD method developed earlier by Jinan allowed us to capture the “very slow” G protein dissociation...

Welcome Jinkai Cheng as a new graduate rotation student from the Department of Chemistry in Miao lab!

Welcome Zhenpeng (Alex) Liu to join Miao Lab as an Undergraduate Researcher!

Welcome Minghui Gao as a new graduate rotation student from the Department of Chemistry in Miao lab!

A paper has been published by the Amber development team on “Recent Developments in Amber Biomolecular Simulations“! Abstract Amber is a molecular dynamics (MD) software package first conceived by Peter Kollman, his lab and collaborators to simulate biomolecular systems. The pmemd module is available as a serial version for central processing...

Congratulations to Jinan and Keya for a new paper just published in Nature Communications on “Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR“! Thanks to Profs. David Thal, Celine Valant and Arthur Christopoulos at Monash University and other team members for the wonderful collaboration! Abstract The M5 muscarinic...

Congratulations to Sana for a jointly first-authored paper published in Nucleic Acids Research on “Mechanistic studies of small molecule ligands selective to RNA single G bulges“! Thanks to Prof. Jingxin Wang’s lab at University of Chicago, Dr. Qi Gao at Merck and other team members for the wonderful collaboration! Abstract...

Congratulations to Tyler for being selected for the Pharmacology T32 Training Program!