Welcome to the Pharmacology Department!

Henrik Dolman, PhD, ChairOur Graduate Program is dedicated to the training of outstanding scientists in the pharmacological sciences. 
An outstanding graduate program is a high priority of our department, and the training faculty participate fully at all levels. Our department ranks consistently in the highest levels of NIH funding for pharmacology departments nationwide and a great diversity of research areas is available to trainees. more

The Department of Pharmacology ranks #4 in the nation in NIH research funding in its field.

Our Global Science Ranking: #2 In the World in Pharmacology and Toxicology Research and Publications, according to U.S. News & World Report's Best Global Universities 2016 report.

Carolina ranked top college value for 16th time in American public higher education, according to Kiplinger’s Personal Finance! 

We welcome Henrik Dohlman, PhD, as the new Chair of the Pharmacology Department, effective October 1, 2016!

Science Highlights: Inside the world of cell signaling: a G-protein breakthrough

Congratulations to the Sondek Lab for their paper published in the December 2, 2016 issue of Journal of Biological Chemistry! UNC scientists led by John Sondek, PhD, created a new biochemical tool to block specific types of downstream G-protein signaling, opening new avenues of research and potential drug design and discovery. 

The paper, "Potent and Selective Peptide-based Inhibition of the G Protein Gαq" describes how they have developed small proteins called peptides that selectively block a certain type of G-protein signaling, which plays a central role in the normal functioning of cells and can go awry to cause severe disease, including cancers. The peptides comprise a unique and powerful tool for studying this type of signaling and the processes in cells that depend on it. 

Aside from their value as basic scientific research tools, these peptides will be used to develop potential drugs for diseases involving abnormal G-protein signaling, including a form of melanoma for which there is currently no cure.  

Gαq uses a conserved mechanism to engage effectors.
Gαq uses a conserved mechanism to engage effectors.


Science Highlights: Engineering Control of Cellular Proteins - An Optogenetics Breakthrough

Congratulations to the Hahn Lab for their paper published in the December 16, 2016 issue of Science titled, "Engineering extrinsic disorder to control protein activity in living cells." Light- or ligand-sensitive domains were used to modulate the structural disorder of diverse proteins, thereby generating robust allosteric switches. 

Photo-inhibition of Src kinase. SYF cell expressing photo-inhibitable Src (PI-Src). Irradiation caused the PI-Src to reversibly translocate to focal adhesions. This was accompanied to varying degrees by cell polarization, cell translation, and increased edge dynamics. Blue dot indicates irradiation. Cell was visualized using PI-Src-mCherry. Video by Onur Dagliyan. read more...

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Upcoming Events
Seminar presented by Dr. Aashish Manglik, Stanford University School of Medicine Jan 17, 2017 04:00 PM - 05:00 PM — 1131 Bioinformatics Auditorium
Seminar presented by Dr. Lulu Cambronne, Oregon Health & Science University Jan 19, 2017 04:00 PM - 05:00 PM — 1131 Bioinformatics Auditorium
Seminar presented by Dr. Selma Masri, University of California, Irvine Jan 24, 2017 04:00 PM - 05:00 PM — 1131 Bioinformatics Auditorium
Student Research Seminar Series presents: Alex Chung and Sam Eaton Jan 27, 2017 12:00 PM - 01:00 PM — 4007 Genetic Medicine Building
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