Precision Health Genetic Screening (PHGS)
The Precision Health Genetic Screen (PHGS) is a genetic screening test for healthy adults in the UNC Health System. The goal is to identify the 1-3% of the population that has a high risk of treatable genetic disease and improve patient outcomes by enabling health care providers to intervene before symptoms develop. The PHGS includes genetic testing for 11 genes linked to 3 highly actionable conditions: Hereditary Breast and Ovarian Cancer syndrome, Lynch syndrome, and Familial Hypercholesterolemia. The genes on the PHGS were selected because we have lots of information on the conditions they can cause. We also have treatment options for individuals that have changes in these genes.
Conditions and genes included on the PHGS:
| Condition | About the condition | Genes screened |
| Hereditary Breast and Ovarian Cancer Syndrome (HBOC) | Increased chance of developing several types of cancer, including breast and ovarian cancers. |
BRCA1, BRCA2 |
| Lynch Syndrome |
Increased chance of developing several types of cancer, including colon, uterine, ovarian, stomach, skin, and urinary tract cancers. |
MLH1, MSH2, MSH6, PMS2, EPCAM |
| Familial Hypercholesterolemia | High levels of cholesterol in the blood, which can lead to early heart attacks and heart disease if not treated. |
APOB, LDLR, LDLRAP1, PCSK9 |
To learn more about PHGS or to request a screening, please visit UNC Health Precision Health Genetic Screen.