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UNC Center for Women’s Mood Disorders has research studies available for women struggling with severe premenstrual symptoms. These studies offer free diagnostic evaluation and, for those who qualify, free study-related treatment and/or monetary compensation. All studies are intended to investigate the causes of PMDD and will help guide the development of future treatment interventions.


Get involved in PMDD Research!


Read about new findings by UNC experts:

News Article: Oral Contraceptives May Ease Suffering of Women with Severe PMS
News Article: Researchers at UNC find hereditary link to PMDD

Current Research Studies at UNC

PMDD study logo

(Menstrually-Related Mood Disorders Screening)

If you suffer during the week before menstruation from depression, anxiety, irritability or mood swings, and these symptoms are severe enough to interfere with normal functioning or interpersonal relationships – you are not alone! Up to 30% of reproductive age women suffer from clinically significant premenstrual symptoms (PMS).

What is involved?

This research study offers free diagnostic evaluation for menstrually related mood disorder (MRMD) and premenstrual dysphoric disorder (PMDD). Participation involves 1-2 study visits over 2-4 months. Monetary compensation may be provided, and women diagnosed in this study with MRMD or PMDD may also qualify for other studies providing monetary compensation.

Am I eligible?PMDD Study image

We are looking for women who:

1) Are between the ages of 18-52

2) Have mood symptoms only pre-menstrually, and not after the end of menstruation

3) Are medically healthy and not currently taking hormonal or psychiatric medications

Contact us, or learn more!

Please visit for more information, and to take our 5 minute eligibility survey!

In order to reach a member of our team, you can call or text us at (919) 537-9352 anytime. You can also email us at with questions or for more information.

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