Research led by Kathleen Metz and Erika Deoudes of the Phanstiel Lab in the Thurston Arthritis Research Center was featured in an article and on the cover of the current issue of Cell Systems.
Their work describes an innovative new web application developed by their team to help researchers visualize — and therefore facilitate analysis of — data for an important family of proteins called protein kinases. Humans have over 500 protein kinases that control cell signaling by modifying proteins with a phosphoryl group in a process called phosphorylation. Their dysfunction has been linked to a variety of human diseases from arthritis to cancer making them targets for past, current, and future drug development.
The software tool that Dr. Phanstiel’s team developed provides new paradigms for visualizing data across all protein kinases at once, and improves our ability to understand signaling, protein phosphorylation, and
the effect of kinase inhibitor drugs.
Learn more about “Coral,” the newly developed software tool.
Watch a brief, animated video demonstrating how the tool works.