Saskia Neher

Research: Maturation and regulation of a group of human lipases

Saskia Neher

Assistant Professor
(PhD - M.I.T)

120 Mason Farm Road, CB# 7260
3042 Genetic Medicine
Chapel Hill, NC 27599-7260

Neher Lab Website


  • NIH Pathway to Independence award, 2010-2014
  • Jane Coffin Childs Memorial Fellow Fund,  2006 - 2009
  • Pew Scholar in the Biomedical Sciences, 2012 - 2016


My lab seeks to better understand the maturation and regulation of a group of human lipases. We aim to uncover how these lipases properly fold and exit the ER, and how their activity is subsequently regulated. We study the membrane-bound and secreted proteins that play a role in lipase regulation. Our research can potentially impact human health as biochemical deficiencies in lipase activity can cause hypertriglyceridemia and associated disorders, such as diabetes and atherosclerosis. We are an interdisciplinary lab and aim to address these questions using a variety of techniques, including membrane protein biochemistry, enzymology, and structural and molecular biology.

RECENT PUBLICATIONS pubmed.png (click for Full Publication List)

  • Lim B, Miyazaki R, Neher S, Siegele DA, Ito K, Walter P, Akiyama Y, Yura T, Gross CA. 2013. Heat Shock Transcription Factor σ(32) Co-opts the Signal Recognition Particle to Regulate Protein Homeostasis in E. coli. PLoS Biol. 11(12)
  • Lafferty MJ, Bradford KC, Erie DA and Neher SB Angiopoietin-like Protein 4 Inhibition of Lipoprotein Lipase: Evidence for Reversible Complex Formation Journal of Biological Chemistry, October, 2013
  • Doolittle MH, Neher SB, Ben-Zeev O, Ling-liao O, Gallagher CM, Hosseini M, Yin F, Wong H, Walter P, Péterfy M. Lipase maturation factor 1 (LMF1): membrane topology and interaction with lipase proteins in the endoplasmic reticulum. JBC Nov. 2009; 284(48):33623-33
  • Bradshaw N*, Neher SB*, Booth DA, Walter, P. Signal sequences activate the catalytic switch of SRP RNA Science, 2009 Jan;323(5910): 127-30. *equal contribution
  • Neher SB*, Bradshaw N*, Floor S, Gross JD, Walter P. SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction. Nature Structural and Molecular Biology, 2008, Sept; 15(9): 916-23. *equal contribution
  • Pruteanu M, Neher SB, Baker TA. Ligand-controlled proteolysis of the Escherichia coli transcriptional regulator ZntR. J Bacteriol. 2007 Apr;189(8):3017-25
  • Neher SB, Villen J, Oakes EC, Bakalarski CE, Sauer RT, Gygi SP, Baker TA. Proteomic profiling of ClpXP substrates following DNA damage reveals extensive instability within SOS regulon. Mol Cell. 2006 Apr 21;22(2):193-204

Lab Contact:

Lab Rooms: 3023C Genetic Medicine
Lab Phone: 919-843-5865
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