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Journal Covers and highlighted articles by Pharmacology faculty.
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Johnson Lab - Cell Stem Cell publication May 6, 2011.
"MAP3K4/CBP-Regulated H2B Acetylation Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells." Cell Stem Cell 8(5): 525-537, 2011. online article
Commentary: "An Epigenetic Mark that Protects the Epithelial Phenotype in Health and Disease" in Cell Stem Cell 8(5): 462-463, 2011. online article
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Dohlman Lab - Science Signaling publication February 8, 2011.
Highlighted in Science Editor's Choice February 25, 2011 as "Cell Signaling: Receptor Free Signaling."
"The Crystal Structure of a Self-Activating G Protein Alpha Subunit Reveals Its Distinct Method of Signal Initiation." Science Signaling 4(159): ra8, 2010. online article
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Dohlman Lab - Molecular Cell publication June 11, 2010.
Highlighted in Science Signaling Editor's Choice June 29, 2010 as "G Protein Signaling Is Not a Done Deal."
"Systematic Analysis of Essential Genes Reveals Important Regulators of G Protein Signaling." Molecular Cell 38(5): 746-757, 2010. online article
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Harden Lab and Sondek Lab - Science publication October 21, 2010.
"Kinetic Scaffolding Mediated by a Phospholipase C-β and Gq Signaling Complex." Science 330: 974-980, 2010. online article
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Whitehurst Lab - Cover of Molecular and Cellular Biology, Nov., 2010.
"Symplekin Specifies Mitotic Fidelity by Supporting Microtubule Dynamics." Mol Cell Biol. 30(21):5135-44, 2010. online article
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Whitehurst Lab - Publication highlighted on cover of Cancer Research, October 1, 2010.
"Tumor Antigen Acrosin Binding Protein Normalizes Mitotic Spindle Function to Promote Cancer Cell Proliferation." Cancer Res. 70(19): 7652-7661, 2010. online article
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Hahn Lab - Research with biosensors and photoactivatable proteins highlighted in the 10th Anniversary Issue of Nature Reviews Molecular Cell Biology October 2010, 11(10): 680.
"Sensing and Controlling Protein Dyanmics" by Katherine H. Wrighton. article
"The work of Klaus Hahn has transformed biosensors into major cell biological tools that have revealed new and important insights." ~Rick Horwitz, University of Virginia
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Hahn Lab - Research using the LOV protein to control the ability to move and activiate cells with light is highlighted in the Fall 2010 edition of Endeavors, UNC's Research and Creative Activity Magazine.
"Send in the Cells" by Susan Hardy article
Hahn Lab cell cinema movies of moving cells with light
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Cox and Der Labs - Small GTPases Cover Vol 1, Issue 1, July-August, 2010
"Ras History: The Saga Continues." Small GTPases 1(1):2-27.
This is the first volume, first issue, first article, and first cover of Small GTPases journal. About the cover
Online Article
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Hahn Lab - Nature Biotechnology highlighted publication, June 27, 2010
"Engineered allosteric activation of kinases in living cells." Nature Biotechnology June 27, 2010 [epub before publication].
Online Article
Article in UNC School of Medicine news
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Johnson Lab - Cover of Journal of Biological Chemistry, April 16, 2010
"Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype." J Biol Chem 285:11760-11764. Online Article
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Cox Lab - Cover of Molecular and Cellular Biology, Feb., 2010
Online cover image and description
Related article: "The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis." Mol Cell Biol 29(4): 1035-1049. Online Article
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McCarthy Lab - Science publication, March 5, 2010
"Hippocampal Short- and Long-term Plasticity are not Modulated by Astrocyte Ca2+ Signaling." Science 327(5970): 1250-1254, 2010. Online Article in Science
Commentary in Science on paper
Nature's Highlighting of paper
Nature Review Neuroscience's Highlighting of paper
A link for free access to Science's online full text article can be found on the McCarthy faculty page under publications.
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Roth Lab - Nature publication, Nov. 12, 2009
"Predicting new molecular targets for known drugs." Nature 462(7270):175-81, 2009. Online Article
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Polleux Lab - Cover of Cell, September 4, 2009
"The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis." Cell 138:990-1004. Online Article
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Hahn Lab - Highlighted Nature publication - Published back to back in same issue with Nature paper listed below.
"Genetically-encoded photoactivatable Rac reveals spatiotemporal coordination of Rac and Rho during cell motility." Nature 461: 104-110, 2009. View movie of cell ruffles induced in a HeLa cell expressing PA-Rac1. See more supplemental movies. Online Article
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Hahn and Johnson Labs - Nature publication - Published back to back in same issue with Nature paper listed above.
"Coordination of Rho GTPase activities during cell protrusion." Nature, 461: 99-103, 2009. Onine Article
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Hahn Lab - Cover of Immunology
"RhoA GTPase Activation by TLR2 and TLR3 Ligands: Connecting via Src to NF-B." Abstract
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Samulski Lab - Cover of Virology
"Enhancement of adeno-associated virus infection by mobilizing capsids into and out of the nucleolus." Abstract
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Harden and Sondek Labs - Cover of Molecular Cell
"General and versatile autoinhibition of phospholipase C isozymes. " Abstract
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Samulski Lab - Cover of Molecular Therapy
"Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles" Abstract
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David Siderovski and Francis Willard are Guest Editors for a two-issue set of papers in the journal Combinatorial Chemistry and High Throughput Screening describing "new technologies and new opportunities for screening compound libraries for modulators of GPCR signaling."
Their editorial introduction to the June 2008 issue can be read here. |
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Samulski Lab - Cover of Virology
"Surface loop dynamics in adeno-associated virus capsid assembly." Abstract
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Zhang Lab - Cover of Cancer Cell
"Targeted inactivation of Mdm2 E3 ubiquitin ligase activity in the mouse reveals novel mechanistic insights into p53 regulation." Abstract
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Samulski Lab - Cover of Virology
"Surface-exposed adeno-associated virus Vp1-NLS capsid fusion protein rescues infectivity of noninfectious wild-type Vp2/Vp3 and Vp3-only capsids but not that of fivefold pore mutant virions." Abstract
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Richard Mailman - Cover of Trends in Pharmacological Sciences
"GPCR functional selectivity has therapeutic impact" Abstract
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McCarthy Lab - Neuron publication
"Selective Stimulation of Astrocyte Calcium In Situ Does Not Affect Neuronal Excitatory Synaptic Activity" Abstract
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Gary Johnson is Guest Editor for the May 14, 2007 issue of Oncogene, along with DN Dhanasekaran. Oncogene issue
Their introduction to the issue is titled "MAPKs: function, regulation, role in cancer and therapeutic targeting." Article
Figure 1: "Integration of the MAPK pathway in the cellular response to environmental stimuli." Artwork by Betsy Clarke.
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Siderovski Lab - Research on G-alpha proteins is highlighted in the Spring 2007 edition of Endeavors, UNC's Research and Creative Activity Magazine.
"Picture Perfect Proteins" by Molly Davis Article
Before and After Photo of protein-crystallization image stablized by the addition of a peptide, making the image crystal clear.
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Wang Lab - Cover of Molecular Cell
"General and specific functions of exonic splicing silencers in splicing control."Abstract
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Johnson Lab - Cover of Journal of Biological Chemistry
"MEKK4 is an effector of the embryonic TRAF4 for JNK activation." Abstract
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Parise Lab - Research on sickle cell adhesion is highlighted in the Spring 2006 edition of Endeavors, UNC's Research and Creative Activity Magazine.
"Getting Past Stickiness" by Jan McColm Article
Photo of Leslie Parise, Julie Brittain and Sheritha Lee.
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Hahn Lab - Cover of Cytometry
"Functional Proteometrics for Cell Migration" Abstract
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Cox Lab - Cover of Molecular Cell
"PKC Regulates a Farnesyl-Electrostatic Switch on K-Ras that Promotes its Association with Bcl-XL on Mitochondria and Induces Apoptosis" Abstract
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Hahn Lab - Nature publication
"Spatiotemporal dynamics of RhoA activity in migrating cells" Abstract
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Nicholas Lab - Selected as the highlight paper in Journal of Bacteriology
"Porin-Mediated Antibiotic Resistance in Neisseria gonorrhoeae: Ion, Solute, and Antibiotic Permeation through PIB Proteins with penB Mutations" Abstract
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Parise Lab - Cover of the Journal of Cell Biology
"Essential role of CIB1 in regulating PAK1 activation and cell migration" Abstract
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Sondek Lab - Cover of Structure
"Crystal structures of the type III effector protein AvrPphF and its chaperone reveal residues required for plant pathogenesis" Abstract
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