Our group’s work emphasizes clinical and human laboratory approaches to studying alcohol use disorder (AUD) and other addictive disorders, with a joint focus on etiology and treatment studies. Several of our recent studies of AUD etiology have utilized alcohol administration and self-administration procedures, including intravenous alcohol administration and self-administration methods. The major aim of these studies is to characterize individual differences in behavioral, cognitive and subjective indices of alcohol motivation and response as they relate to the early manifestation of problem drinking in youth. These projects have also included neuroimaging extensions to investigate neural markers of alcohol sensitivity and drinking behavior in young drinkers. Our recent treatment-oriented research has included randomized clinical trials to investigate both cognitive and pharmacological interventions, and to evaluate ways of improving intervention delivery in both clinical and population settings. As a means of bridging our human experimental and treatment research, we are currently carrying out Phase II clinical trials involving human laboratory models of drug self-administration and relapse; these studies aim to investigate candidate therapies for AUD and smoking cessation on the basis of preclinical findings.
Aschbacher, K., Hendershot, C.S., Hahn, J.A., Tison, G., Avram, R., Olgin, J.E., & Marcus, G.M. (2021). Artificial intelligence prediction of blood alcohol concentration: A digital signature of smart-breathalyzer behavior. Nature Digital Medicine, 4(1): 74.
Best, L.M., Wardell, J.D., Tyndale, R.F., McPhee, M.D., Le Foll, B., Kish, S.J., Boileau, I., & Hendershot, C.S. (2021). Association of the fatty acid amide hydrolase polymorphism with alcohol use severity and coping motives in heavy-drinking youth. Alcoholism: Clinical and Experimental Research, 45, 507-517.
Hendershot, C.S., Dermody, S.S., Wardell, J.D., Zaso, M.J., Kennedy, J.L., & Stoner, S.A. (2020). OPRM1 moderates daily associations of naltrexone adherence with alcohol consumption: Preliminary evidence from a mobile health trial. Alcoholism: Clinical and Experimental Research, 44, 983-991.
Lindgren, K.P., Hendershot, C.S., Ramirez, J.J., Bernat, E., Rangel-Gomez, M., Peterson, K.P., & Murphy, J.G. (2019). A dual process perspective on advances in cognitive science and alcohol use disorder. Clinical Psychology Review, 69, 83-96.
Hendershot, C.S., Wardell, J.D., Vandervoort, J., McPhee, M.D., Keough, M.T., & Quilty, L.C. (2018). Randomized trial of working memory training as an adjunct to inpatient substance use disorder treatment. Psychology of Addictive Behaviors, 32, 861-872.
Hendershot, C.S., Wardell, J.D., McPhee, M.D., & Ramchandani, V.A. (2017). A prospective study of genetic factors, human laboratory phenotypes, and heavy drinking in late adolescence. Addiction Biology, 22, 1343-1354.
Hendershot, C.S., Wardell, J.D., Samokhvalov, A.V., & Rehm, J. (2017). Effects of naltrexone on alcohol self-administration and craving: Meta-analysis of human laboratory studies. Addiction Biology, 22, 1515-1527.