Scott Parnell, Ph.D.
Department of Cell Biology and Physiology
Bowles Center for Alcohol Studies
My research interests are in understanding the detrimental effects of ethanol and other drugs of abuse, such as cannabinoids, during early development, the underlying mechanisms of these birth defects and genes that modify susceptibility to prenatal teratogens. My lab uses a wide variety of techniques ranging from mouse behavioral phenotyping and high-resolution magnetic resonance imaging (MRI) to in situ hybridization, molecular biology and RNA-seq to answer these important questions about what drugs of abuse do to the developing embryo and how they cause these effects.
Combined Face-Brain Morphology and Associated Neurocognitive Correlates In Fetal Alcohol Spectrum Disorders. Suttie M, Wozniak JR, Parnell SE, Wetherill L, Mattson SN, Sowell ER, Kan E, Riley EP, Jones KL, Coles C, Foroud T, Hammond P; CIFASD. Alcohol Clin Exp Res. 2018 Jun 23. doi: 10.1111/acer.13820. PMID: 29935097
A novel method for determining sex in late term gestational mice based on the external genitalia. Murdaugh LB, Mendoza-Romero HN, Fish EW, Parnell SE. PLoS One. 2018 Apr 4;13(4):e0194767. doi: 10.1371/journal.pone.0194767. eCollection 2018. PMID: 29617407
Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice. Li F, Kakoki M, Smid M, Boggess K, Wilder J, Hiller S, Bounajim C, Parnell SE, Sulik KK, Smithies O, Maeda-Smithies N. Hypertension. 2018 May;71(5):894-903. doi: 10.1161/HYPERTENSIONAHA.117.10849. Epub 2018 Apr 2. PMID: 29610266
The contributions of Dr. Kathleen K. Sulik to fetal alcohol spectrum disorders research and prevention. Parnell SE, Riley EP, Warren KR, Mitchell KT, Charness ME. Alcohol. 2018 Jun;69:15-24. doi: 10.1016/j.alcohol.2017.10.008. Epub 2018 Mar 20. Review. PMID: 29571046
Genetic vulnerabilities to prenatal alcohol exposure: Limb defects in sonic hedgehog and GLI2 heterozygous mice. Fish EW, Murdaugh LB, Sulik KK, Williams KP, Parnell SE. Birth Defects Res. 2017 Jul 3;109(11):860-865. doi: 10.1002/bdr2.1026. Epub 2017 May 15. PMID: 28504423