Assistant ProfessorParnell
Department of Cell Biology and Physiology
Bowles Center for Alcohol Studies

Office | 3019 Thurston-Bowles Bldg, CB# 7178
Email | sparnell@med.unc.edu
Lab Website | Parnell Lab
Biographical Sketch |
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Research Interests

My research interests are in understanding the detrimental effects of ethanol and other drugs of abuse, such as cannabinoids, during early development, the underlying mechanisms of these birth defects and genes that modify susceptibility to prenatal teratogens. My lab uses a wide variety of techniques ranging from mouse behavioral phenotyping and high-resolution magnetic resonance imaging (MRI) to in situ hybridization, molecular biology and RNA-seq to answer these important questions about what drugs of abuse do to the developing embryo and how they cause these effects.

Recent Publications

Click here for a full list of publications from PubMed

Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice. Fish EW, Parnell SE, Sulik KK, Baker LK, Murdaugh LB, Lamson D, Williams KP. Birth Defects Res A Clin Mol Teratol. 2016 Nov 1. doi: 10.1002/bdra.23571. [Epub ahead of print] PMID:27801979

The Genetics of Fetal Alcohol Spectrum Disorders. Eberhart JK, Parnell SE. Alcohol Clin Exp Res. 2016 Jun;40(6):1154-65. doi: 10.1111/acer.13066. Review. PMID:27122355

Dose-dependent teratogenicity of the synthetic cannabinoid CP-55,940 in mice. Gilbert MT, Sulik KK, Fish EW, Baker LK, Dehart DB, Parnell SE. Neurotoxicol Teratol. 2015 Dec 18. PMID: 26708672

Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects. Veazey KJ, Parnell SE, Miranda RC, Golding MC. Epigenetics Chromatin. 2015 Sep 28. PMID: 26421061

Hypothalamic-pituitary-adrenal axis and behavioral dysfunction following early binge-like prenatal alcohol exposure in mice. Wieczorek L, Fish EW, O’Leary-Moore SK, Parnell SE, Sulik KK. Alcohol. 2015 May;49(3):207-17. PMID: 25709101