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Research Assistant Professor

Bowles Center for Alcohol Studies

Department of Pharmacology

Office: 1007C Thurston Bowles Bldg CB#7178

Email: leon_coleman@med.unc.edu

Biographical Sketch: Biosketch-Coleman-R01

 

Research Interests

The overriding goal of Dr. Coleman’s work is to identify novel treatments for alcohol use disorders and peripheral immune pathologies.  Currently, this includes two main projects:

Neuroimmune Signaling in Alcohol Use Disorders: The goal of this project is to determine the role of innate immune induction in the pathology of alcohol addiction across the lifespan.  This project examines the overall hypothesis that chronic ethanol induces innate immune signaling via Toll-like Receptors and cytokines, causing neurotoxicity and behavioral phenotypes associated with alcoholism.  Specific immune inhibitors are assessed for their efficacy in models of chronic alcohol abuse.

Peripheral Immune Dysfunction in Systemic Inflammatory Diseases: Alcoholics have altered peripheral immune function, associated with increased risk for sepsis and sepsis-related complications.  The goal of this project is to identify critical mediators of systemic immune dysfunction in critical illness settings such as sepsis and burn injury.  We hope to identify common pathways in alcohol abuse and critical illnesses that can be targeted for intervention to improve patient outcomes.

 

Recent Publications

Click here for a full list of publications from PubMed

The role of neuroimmune signaling in alcoholism.  Crews FT, Lawrimore CJ, Walter TJ, Coleman LG JrNeuropharmacology. 2017 Aug 1;122:56-73. Review. PubMed PMID: 28159648

Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7.  Coleman LG Jr, Zou J, Crews FT.  J Neuroinflammation. 2017 Jan 25;14(1):22. PMID: 28159648

Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice.  Coleman LG Jr, He J, Lee J, Styner M, Crews FT.  Alcohol Clin Exp Res. 2011 Apr;35(4):671-88. PubMed PMID: 21223304