Leon Coleman, M.D., Ph.D.
Research Assistant Professor
Bowles Center for Alcohol Studies
Department of Pharmacology
Office: 1007C Thurston Bowles Bldg CB#7178
Biographical Sketch: Biosketch-Coleman-R01
The overriding goal of Dr. Coleman’s work is to identify novel treatments for alcohol use disorders and peripheral immune pathologies. Currently, this includes two main projects:
Neuroimmune Signaling in Alcohol Use Disorders: The goal of this project is to determine the role of innate immune induction in the pathology of alcohol addiction across the lifespan. This project examines the overall hypothesis that chronic ethanol induces innate immune signaling via Toll-like Receptors and cytokines, causing neurotoxicity and behavioral phenotypes associated with alcoholism. Specific immune inhibitors are assessed for their efficacy in models of chronic alcohol abuse.
Peripheral Immune Dysfunction in Systemic Inflammatory Diseases: Alcoholics have altered peripheral immune function, associated with increased risk for sepsis and sepsis-related complications. The goal of this project is to identify critical mediators of systemic immune dysfunction in critical illness settings such as sepsis and burn injury. We hope to identify common pathways in alcohol abuse and critical illnesses that can be targeted for intervention to improve patient outcomes.
- Innate Immune Signaling and Alcohol Use Disorders. Coleman LG Jr., Crews FT. Handb Exp Pharmacol. 2018 Mar 3. PubMed PMID: 29500721.
- HMGB1/IL-1β complexes in plasma microvesicles modulate immune responses to burn injury.Coleman LG Jr, Maile R, Jones SW, Cairns BA, Crews FT. PLoS One. 2018 Mar 30;13(3):e0195335. doi: 10.1371/journal.pone.0195335. PubMed PMID: 29601597.
- HMGB1/IL-1β complexes regulate neuroimmune responses in alcoholism. Coleman LG Jr, Zou J, Qin L, Crews FT. Brain Behav Immun. 2017 Nov 2. PubMed PMID: 29102800.
The role of neuroimmune signaling in alcoholism. Crews FT, Lawrimore CJ, Walter TJ, Coleman LG Jr. Neuropharmacology. 2017 Aug 1;122:56-73. Review. PubMed PMID: 28159648
Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7. Coleman LG Jr, Zou J, Crews FT. J Neuroinflammation. 2017 Jan 25;14(1):22. PMID: 28159648
Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice. Coleman LG Jr, He J, Lee J, Styner M, Crews FT. Alcohol Clin Exp Res. 2011 Apr;35(4):671-88. PubMed PMID: 21223304