GWAS Summary Statistics for Brain Imaging Phenotypes

Involved datasets: UK Biobank (UKB), Adolescent Brain Cognitive Development (ABCD) Study, Human Connectome Project (HCP), Philadelphia Neurodevelopmental Cohort (PNC), Alzheimer’s Disease` Neuroimaging Initiative (ADNI), Pediatric Imaging, Neurocognition, and Genetics (PING)

Terms of Use:

• By downloading these data, you acknowledge that they will be used for research purposes and that you are in compliance with applicable rules, policies and regulations.
• When reporting results of research that utilizes these data we request that you cite the original publication.

GWAS summary statistics for 200 resting-state functional MRI (rs-fMRI) traits

• Sample size: n=34,691
• Version: July 15, 2020
• Download Summary Statistics:

  Data available at Zenodo
  https://doi.org/10.5281/zenodo.5775047

• Description: readme
• Citation: Zhao et al (2020) Common variants contribute to intrinsic human brain functional networks. Nature Genetics. https://doi.org/10.1038/s41588-022-01039-6

GWAS summary statistics for 635 tract-specific diffusion tensor imaging (DTI) parameters

• Sample size: n=33,292
• Version: July 15, 2020
• Download Summary Statistics:

  wget --no-check-certificate --content-disposition https://github.com/stat-yyang/sumstats/blob/master/110_mean.list 
  wget --no-check-certificate --content-disposition https://github.com/stat-yyang/sumstats/blob/master/105_mopcs.list 
  wget --no-check-certificate --content-disposition https://github.com/stat-yyang/sumstats/blob/master/105_rdpcs.list 
  wget --no-check-certificate --content-disposition https://github.com/stat-yyang/sumstats/blob/master/105_adpcs.list 
  wget --no-check-certificate --content-disposition https://github.com/stat-yyang/sumstats/blob/master/105_mdpcs.list 
  wget --no-check-certificate --content-disposition https://github.com/stat-yyang/sumstats/blob/master/105_fapcss.list
  wget -i 110_mean.list
  wget -i 105_mopcs.list
  wget -i 105_rdpcs.list
  wget -i 105_adpcs.list
  wget -i 105_mdpcs.list
  wget -i 105_fapcs.list
  
  Data available at Zenodo
  mean: https://doi.org/10.5281/zenodo.4549730
  MO PC: https://doi.org/10.5281/zenodo.4553513
  RD PC: https://doi.org/10.5281/zenodo.4553510
  AD PC: https://doi.org/10.5281/zenodo.4553514
  MD PC:  https://doi.org/10.5281/zenodo.4549693
  FA PC: https://doi.org/10.5281/zenodo.4549725

• Description:  readme
• Citation: Zhao et al (2021) Common genetic variation influencing human white matter microstructure. Science. https://doi.org/10.1126/science.abf3736.

GWAS Summary Statistics for 101 Brain Regional Volumes

• Sample size: n=19,629
• Version: May 24, 2019
• Download links:     GWAS Summary Statistics       readme (UK Biobank)       readme (meta-analysis)
• Citation: Zhao et al. (2019) Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health` Traits. Nature Genetics. https://www.nature.com/articles/s41588-019-0516-6

GWAS summary statistics for 110 brain regional diffusion tensor imaging (DTI) parameters

• Sample size: n=17,706
• Version: March 11, 2019
• Download links:     GWAS Summary Statistics       readme
• Citation: Zhao et al. (2019) Large-scale GWAS reveals genetic architecture of brain white matter microstructure and genetic overlap with cognitive and mental health` traits (n=17,706). Molecular Psychiatry. https://www.nature.com/articles/s41380-019-0569-z

Summary statistics of the sex chromosomes for 2,822 brain imaging traits

• Sample size: n=34,000
• Version: Sept. 1, 2023
• Download Summary Statistics: GWAS Summary Statistics       readme
• Citation: Jiang et al. (2023) The pivotal role of the X-chromosome in the genetic architecture of the human brain. medRxiv. https://doi.org/10.1101/2023.08.30.23294848