BCBP Seminar: Lindsay Case PhD

Lindsay Case, Ph.D., Assistant Professor, Biology

Massachusetts Institute of Technology (MIT)

Host: Rebecca Berlow

Talk Title: Phase separation regulates integrin clustering and downstream signaling

Dr. Case has a B. A. in Biology and French from Franklin and Marshall College and a Ph.D. in Cell and Developmental Biology from UNC-Chapel Hill. She is currently Assistant Professor in the Biology Department at MIT since January, 2021. Prior to her faculty appointment at MIT, she was a postdoctoral scholar at UT Southwestern Medical Center in Dallas TX. Her research focuses on how cells regulate the spatial organization of signaling molecules at the plasma membrane to control downstream signaling.

Research: Case lab studies how molecules are concentrated and organized at the plasma membrane to regulate transmembrane signaling. We study how cells regulate the spatial organization of signaling molecules at the plasma membrane to control downstream signaling. For example, receptor clustering and higher-order assembly with cytoplasmic proteins can create compartments with unique biochemical and biophysical properties. We use quantitative experimental approaches from biochemistry, molecular biophysics, and cell biology to study transmembrane signaling pathways and how they are misregulated in diseases like cancer.