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Seminar: David Fruman, PhD (UC Irvine)

August 27 @ 11:00 am - 12:00 pm

DAVID FRUMAN speaks at Biochemistry seminar on August 27 2019 at 11am

DAVID FRUMAN, PHD ǀ University of California- Irvine                                                                        Host: Pengda Liu

“Strategies to target the mTORC1/eIF4F Axis in B-cell malignancies”

Abstract:

mTOR complex-1 (mTORC1) is a key regulator of B cell proliferation and differentiation. Elevated mTORC1 activity is also common in B cell cancers and is associated with poor prognosis. We have shown that eukaryotic initiation factor 4F (eIF4F) is a key mTORC1 effector pathway in the activation and differentiation of normal B cells. This seminar will describe current efforts to develop improved approaches to target the mTORC1/eIF4F axis in B cell leukemia and lymphoma.

Details

Date:
August 27
Time:
11:00 am - 12:00 pm
Event Categories:
,

Venue

Bioinformatics 1131
130 Mason Farm Road
Chapel Hill, NC 27514 United States

Organizer

Jamie Desoto
Phone:
919-843-9986
Email:
Jamie_Desoto@unc.edu