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Seminar: Neil King, PhD (UW)

April 21 @ 11:00 am - 12:00 pm

Neil King PhD UW 4.21.2020 seminar

Title: Computational Design of Protein-based Nanomaterials for Medical Applications”

Speaker: Neil King, PhD Assistant Professor, Institute for Protein Design University of Washington

Neil is at the Protein Design Institute at the University of Washington and has done some beautiful work designing proteins that self-assemble into multi-subunit protein cages.  They are using these for a variety of applications including scaffolding proteins from SARS-CoV-2 for use as vaccines (https://www.statnews.com/2020/03/09/coronavirus-scientists-play-legos-with-proteins-to-build-next-gen-vaccine/ ).  

Abstract: Proteins are Nature’s building block of choice for the construction of ‘molecular machines’: stable yet dynamic assemblies with unparalleled abilities in molecular recognition and logic. The King group incorporates these features into the design of functional protein-based nanomaterials with the goal of creating new opportunities for the treatment and prevention of disease. We use computational protein design and a variety of biochemical, biophysical, and structural techniques to produce and characterize our novel materials. Current areas of focus include the design of protein-based materials for biologics delivery and structure-based design of nanoparticle vaccines.

Recent publications:

Marcandalli, Jessica, et al. “Induction of potent neutralizing antibody responses by a designed protein nanoparticle vaccine for respiratory syncytial virus.” Cell 176.6 (2019): 1420-1431.
Butterfield, Gabriel L., et al. “Evolution of a designed protein assembly encapsulating its own RNA genome.” Nature 552.7685 (2017): 415-420.
King, Neil P., et al. “Accurate design of co-assembling multi-component protein nanomaterials.” Nature 510.7503 (2014): 103-108.

Date: Tuesday, April 21, 2020

Time:  11:00 AM

Location: This event will be broadcast via Zoom. Link will be provided through UNC Biochemistry and Biophysics emails. Contact Jamie_DeSoto@unc.edu for meeting link and password.

Host: Brian Kuhlman

Details

Date:
April 21
Time:
11:00 am - 12:00 pm
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