June 10, 2025
Published article in Biophys Journal: Modeling platelet P2Y1/12 pathway to integrin activation. Authors: Patel KB, Bergmeier W, Fogelson AL.
June 10, 2025
Published article in JTH: Lack of overt bleeding or platelet dysfunction in a mouse model of vascular Ehlers-Danlos syndrome. Authors: Lee RH, Jones SR, Martyanov AA, Vander Ploeg MR, Sagues CF, Bergmeier W.
June 5, 2025
UNC’s Vital Signs highlighted work from the Wolberg laboratory (https://news.unchealthcare.org/2025/05/unc-study-offers-new-hope-for-safer-bleeding-treatments/) that is currently in press in Blood (https://ashpublications.org/blood/article/doi/10.1182/blood.2025028680/537391/Plasminogen-activation-and-plasmin-activity-are). This work showed that plasminogen activation and activity are not required to prevent venous thrombosis/thromboembolism, and suggests that use of antifibrinolytic therapy to decrease bleeding is not expected to increase thrombosis risk. This work was first authored …
June 5, 2025
Dr. Yaqiu Sang, a postdoctoral fellow in Dr. Wolberg’s laboratory was featured in the Brinkhous Bulletin, the Department of Pathology and Laboratory Medicine’s monthly newsletter that reports exciting developments in the department. Dr. Sang was highlighted for her her contributions to the Wolberg lab including her recent paper published in Blood (https://ashpublications.org/blood/article/doi/10.1182/blood.2025028680/537391/Plasminogen-activation-and-plasmin-activity-are).
June 5, 2025
https://www.hematology.org/education/trainees/fellows/hematopoiesis/2025/neurologic-sequelae-of-lead-intoxication-in-a-child-with-sickle-cell-disease An 8-year-old female with sickle cell disease (SCD), hemoglobin SS genotype, global developmental delay, and pica established care shortly after moving from out of state. The patient and her family had been living in a weathered house. The child’s caregiver reported a recent history of weakness in the right side of her body, …
June 5, 2025
Dr. Alisa Wolberg received 2nd year of NIH R01 for “Interdisciplinary approach to elucidate modifiers of bleeding phenotype in factor XI deficiency”. https://grants.nih.gov/funding/activity-codes/R01
June 5, 2025
Dr. Matthew Flick received another year of funding from UVA “Novel mechanism underlying fibrinogen biogenesis in the endoplasmic reticulum”, an NIH funded project. https://reporter.nih.gov/search/xtpB-vhHmkiSnMaozQbkYA/project-details/10874727
May 5, 2025
View BRC January 2025 Newsletter May 2025 Newsletter
April 7, 2025
Swati Sharma has been awarded an Early Career Travel Award to attend the ISTH meeting in Washington, DC, June 21-25, 2025. Each year, the ISTH Congress Scientific Committee rewards abstracts of outstanding quality and provides the submitting author with a Travel Award to attend the ISTH Congress. Three categories of Travel Award are distributed: Early …
April 7, 2025
Alisa S. Wolberg, Ph.D. gave The Dr. William Bell Lecture in Hematology at Johns Hopkins University March 31, 2025. Dr. Wolberg’s lecture was entitled “Venous thromboembolism: fibrinogen, factor XIII, and new potential targets.” Dr. William R. Bell (1935-2013) was an internationally acclaimed hematologist and a professor and researcher at The Johns Hopkins Hospital. During Dr. …
April 3, 2025
Ana Sachetto, PhD, is now a co-chair of the International Postdoc Alliance of the UNC Postdoctoral Association. The University of North Carolina Postdoctoral Association (PDA) is a peer-led volunteer organization dedicated to addressing the needs and concerns of all UNC postdocs. PDA works closely with the Office of Postdoctoral Affairs to provide resources for professional development, generate …
March 21, 2025
Three BRC Labs Collaborate to study Sickle Cell Trait: In a recently published study, three BRC groups (Key, Pawlinski and Kasztan labs) performed an in-depth study of venous thrombosis and chronic kidney disease in heterozygous Townes sickle mice as a model of human sickle cell trait. The authors suggest that the mouse model can be …