Areas of Interest

My research investigates the mechanisms underlying venous and arterial thrombosis in sickle cell anemia (SCA) and myeloproliferative neoplasms (MPN). Despite being distinct diseases, both conditions share a state of chronic systemic inflammation and carry a significantly heightened risk of thrombosis. My work focuses on investigating the role of hypoxia-inducible factors (HIFs) and leukocyte-derived tissue factor (TF) in driving thrombosis, as both are abnormally elevated in SCA and MPN. To uncover the cellular and molecular mechanisms underlying this process, I utilize a combination of in vivo thrombosis models and in vitro studies, aiming to shed light on the factors contributing to thrombotic risk in these conditions.