November 13, 2025
CASP Resources
November 2, 2025
Malaria Diagnosis and Initial Management
Immediate guidance for the initial diagnosis and management of malaria at UNC Hospitals. Infectious Diseases consultation is recommended when malaria is diagnosed or strongly suspected. key words: malaria, antimalarial, artesunate, dengue, Chikungunya, P. falciparum, P. vivax, P. ovale
September 22, 2025
Diagnosis and Management of Clostridioides difficile Infection in Adult and Pediatric Patients
c. diff, c. difficile, fidaxomicin, bezlotoxumab, vancomycin, Clostridioides difficile, CDI, diarrhea, Clostridium difficile
July 25, 2025
Azole Antifungal Therapeutic Drug Monitoring
Certain azole antifungal drugs require therapeutic drug monitoring (TDM) due to important exposureresponse relationships and significant pharmacokinetic variability. This guideline outlines recommendations for the TDM of itraconazole, posaconazole, voriconazole, and isavuconazole.
July 11, 2025
UNC Medical Center Antibiogram
Antimicrobial susceptibility organisms submitted to the University of North Carolina Hospitals Microbiology Laboratory between 1/1/2024 and 12/31/2024. Antibiograms help guide the clinician and pharmacist in selecting the best empiric antimicrobial treatment in the event of pending microbiology culture and susceptibility results.
May 1, 2025
Vancomycin Dosing Guidelines (Adult)
vancomycin, SDD
March 1, 2025
Isolation Precautions
isolation, epidemiology, infection, prevention
January 24, 2025
Antibiotic Dosing for Hemodialysis and Altered Kidney Function
September 26, 2024
Evaluating New Fever in the Pediatric Intensive Care Unit
August 19, 2024
Pediatric Community-acquired Pneumonia (CAP) and Influenza Guidelines
This document provides guidance in management, including diagnostic evaluation, antimicrobial therapy, procedural management, and disposition, of children with community-acquired pneumonia (CAP). It is not intended to replace clinician judgment in individual cases; however, it should apply to the vast majority of patients diagnosed with CAP.
August 1, 2024
Assessment and Management of Hospital-aquired and Ventilator-associated Pneumonia in Children
Hospital-acquired pneumonia (HAP) and Ventilator-associated pneumonia (VAP) are healthcare-acquired conditions with significant risk of morbidity and mortality. Hospitalized patients may have multiple risk factors for pneumonia, such as recumbent position, impaired cough reflex, procedural sedation, immunocompromised status, and/or artificial airways. Prompt recognition of pneumonia in hospitalized patients can prevent serious complications. However, cultures of respiratory secretions are difficult to obtain in patients without an artificial airway or have limited specificity in patients with an endotracheal tube or tracheostomy tube. This guideline document will address the diagnosis and treatment of HAP and VAP in pediatric patients at UNC Children’s. Guidelines for HAP and VAP prevention are maintained separately.
June 30, 2024
Renal Insufficiency and Hemodialysis Antimicrobial Dosing Guideline
Dosing for Altered Kidney Function Doses should be individualized based on: 1) severity of infection, 2) anticipated drug penetration to site of infection; and 3) size of patient (typical dose for 70 kg patient). All weight-based dosing should be calculated using total body weight (TBW) unless otherwise noted. Calculations for ideal body weight (IBW) and adjusted body weight (adjBW) are included.