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March 23, 2023

Antibiotic Selection & Dose Optimization Guide for Pediatric Patients at least One Month of Age with Gram-Negative Infections

The guide serves as an antibiotic selection and dosing reference for clinicians who are providing care to pediatric patients with infectious diseases caused by particular Gram-negative pathogens (e.g., Pseudomonas aeruginosa, AmpC-producing Enterobacterales). These topics were purposefully identified due to the variety of antibiotic dosing recommendations available for pediatric patients; however, depending on the organism or site of infection, specific dosing regimens are required to optimize the pharmacokinetic and pharmacodynamic (PKPD) parameters of the bug-drug-site interaction.