Dr. Bev Koller, Associate Professor, Department of Genetics, received a new R21 grant from NIAID, entitled “Genetically humanized mice for modeling Fc-receptor interaction during influenza infection”.
This two-year award has the overall goal of developing and refining tools for the study of human antibody receptor interactions in vivo. The Koller lab has generated mice in which the three loci encoding IgG receptors are humanized by syntenic replacement. The human receptors are expressed in the mouse lines, making them valuable tools to address the proposed aims.