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UNC Genetics PublicationsDepartment of Genetics faculty, postdocs, students and collaborators published 10 papers during August 27th – September 9th, 2023.

 

SnapHiC-D: a computational pipeline to identify differential chromatin contacts from single-cell Hi-C data. 

Lee L, Yu M, Li X, Zhu C, Zhang Y, Yu H, Chen Z, Mishra S, Ren B, Li Y, Hu M.

Brief Bioinform. 2023 Aug 30:bbad315. doi: 10.1093/bib/bbad315. Online ahead of print.

PMID: 37649383

 

Ancestral diversity in lipoprotein(a) studies helps address evidence gaps. 

Lee MP, Dimos SF, Raffield LM, Wang Z, Ballou AF, Downie CG, Arehart CH, Correa A, de Vries PS, Du Z, Gignoux CR, Gordon-Larsen P, Guo X, Haessler J, Howard AG, Hu Y, Kassahun H, Kent ST, Lopez JAG, Monda KL, North KE, Peters U, Preuss MH, Rich SS, Rhodes SL, Yao J, Yarosh R, Tsai MY, Rotter JI, Kooperberg CL, Loos RJF, Ballantyne C, Avery CL, Graff M.

Open Heart. 2023 Aug;10(2):e002382. doi: 10.1136/openhrt-2023-002382.

PMID: 37648373

 

Cell-type composition affects adipose gene expression associations with cardiometabolic traits. 

Brotman SM, Oravilahti A, Rosen JD, Alvarez M, Heinonen S, van der Kolk B, Silva LF, Perrin HJ, Vadlamudi S, Pylant C, Deochand S, Basta PV, Valone JM, Narain MN, Stringham HM, Boehnke M, Kuusisto J, Love MI, Pietiläinen KH, Pajukanta P, Laakso M, Mohlke KL.

Diabetes. 2023 Aug 30:db230365. doi: 10.2337/db23-0365. Online ahead of print.

PMID: 37647564

 

Extending an Antiracism Lens to the Implementation of Precision Public Health Interventions. 

Allen CG, Olstad DL, Kahkoska AR, Guan Y, Ramos PS, Steinberg J, Staras SAS, Lumpkins CY, Milko LV, Turbitt E, Rahm AK, Saylor KW, Best S, Hatch A, Santangelo I, Roberts MC.

Am J Public Health. 2023 Aug 31:e1-e9. doi: 10.2105/AJPH.2023.307386. Online ahead of print.

PMID: 37651661

 

Coordinated expression of replication-dependent histone genes from multiple loci promotes histone homeostasis in Drosophila

Chaubal A, Waldern JM, Taylor C, Laederach A, Marzluff WF, Duronio RJ.

Mol Biol Cell. 2023 Aug 30:mbcE22110532. doi: 10.1091/mbc.E22-11-0532. Online ahead of print.

PMID: 37647143

 

Pay-it-forward incentives for hepatitis virus testing in men who have sex with men: a cluster randomized trial. 

Zhang Y, Li J, Xie Y, Wu D, Ong J, Marley G, Kamarulzaman A, Lu H, Zou F, Smith JS, Tucker JD, Fu G, Tang W.

Nat Med. 2023 Aug 28. doi: 10.1038/s41591-023-02519-w. Online ahead of print.

PMID: 37640859

 

Derivation and validation of risk prediction for posttraumatic stress symptoms following trauma exposure. 

Kim R, Lin T, Pang G, Liu Y, Tungate AS, Hendry PL, Kurz MC, Peak DA, Jones J, Rathlev NK, Swor RA, Domeier R, Velilla MA, Lewandowski C, Datner E, Pearson C, Lee D, Mitchell PM, McLean SA, Linnstaedt SD.

Psychol Med. 2023 Aug;53(11):4952-4961. doi: 10.1017/S003329172200191X. Epub 2022 Jul 1.

PMID: 35775366

 

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification. 

Lagou V, Jiang L, Ulrich A, Zudina L, González KSG, Balkhiyarova Z, Faggian A, Maina JG, Chen S, Todorov PV, Sharapov S, David A, Marullo L, Mägi R, Rujan RM, Ahlqvist E, Thorleifsson G, Gao Η, Εvangelou Ε, Benyamin B, Scott RA, Isaacs A, Zhao JH, Willems SM, Johnson T, Gieger C, Grallert H, Meisinger C, Müller-Nurasyid M, Strawbridge RJ, Goel A, Rybin D, Albrecht E, Jackson AU, Stringham HM, Corrêa IR Jr, Farber-Eger E, Steinthorsdottir V, Uitterlinden AG, Munroe PB, Brown MJ, Schmidberger J, Holmen O, Thorand B, Hveem K, Wilsgaard T, Mohlke KL, Wang Z; GWA-PA Consortium; Shmeliov A, den Hoed M, Loos RJF, Kratzer W, Haenle M, Koenig W, Boehm BO, Tan TM, Tomas A, Salem V, Barroso I, Tuomilehto J, Boehnke M, Florez JC, Hamsten A, Watkins H, Njølstad I, Wichmann HE, Caulfield MJ, Khaw KT, van Duijn CM, Hofman A, Wareham NJ, Langenberg C, Whitfield JB, Martin NG, Montgomery G, Scapoli C, Tzoulaki I, Elliott P, Thorsteinsdottir U, Stefansson K, Brittain EL, McCarthy MI, Froguel P, Sexton PM, Wootten D, Groop L, Dupuis J, Meigs JB, Deganutti G, Demirkan A, Pers TH, Reynolds CA, Aulchenko YS, Kaakinen MA, Jones B, Prokopenko I; Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC).

Nat Genet. 2023 Sep;55(9):1448-1461. doi: 10.1038/s41588-023-01462-3. Epub 2023 Sep 7.

PMID: 37679419

 

Chromosomal contacts change with age. 

Akbarian S, Won H.

Science. 2023 Sep 8;381(6662):1049-1050. doi: 10.1126/science.adk0961. Epub 2023 Sep 7.

PMID: 37676934

 

Intermediate filament dysregulation in astrocytes in the human disease model of KLHL16 mutation in giant axonal neuropathy (GAN). 

Battaglia R, Faridounnia M, Beltran A, Robinson J, Kinghorn K, Ezzell JA, Bharucha-Goebel D, Bonnemann C, Hooper JE, Opal P, Bouldin TW, Armao D, Snider N.

Mol Biol Cell. 2023 Sep 6:mbcE23030094. doi: 10.1091/mbc.E23-03-0094. Online ahead of print.

PMID: 37672338