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Department of Genetics faculty and collaborators published thirteen papers during the past two weeks.

Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells.

Bower JJ, Vance LD, Psioda M, Smith-Roe SL, Simpson DA, Ibrahim JG, Hoadley KA, Perou CM, Kaufmann WK.

NPJ Breast Cancer. 2017 Mar 31;3:9. doi: 10.1038/s41523-017-0009-7. eCollection 2017.

PMID: 28649649

Biliary Secretion of Quasi-Enveloped Human Hepatitis A Virus.

Hirai-Yuki A, Hensley L, Whitmire JK, Lemon SM.

MBio. 2016 Dec 6;7(6). pii: e01998-16. doi: 10.1128/mBio.01998-16.

PMID: 27923925

Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice.

Schoenrock SA, Oreper D, Young N, Ervin RB, Bogue MA, Valdar W, Tarantino LM.

Physiol Behav. 2016 Dec 1;167:404-412. doi: 10.1016/j.physbeh.2016.09.026. Epub 2016 Sep 29.

PMID: 27693591

Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility.

Bagot RC, Cates HM, Purushothaman I, Lorsch ZS, Walker DM, Wang J, Huang X, Schlüter OM, Maze I, Peña CJ, Heller EA, Issler O, Wang M, Song WM, Stein JL, Liu X, Doyle MA, Scobie KN, Sun HS, Neve RL, Geschwind D, Dong Y, Shen L, Zhang B, Nestler EJ.

Neuron. 2016 Jun 1;90(5):969-83. doi: 10.1016/j.neuron.2016.04.015. Epub 2016 May 12.

PMID: 27181059

A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the Adcy5 Locus.

Roman TS, Cannon ME, Vadlamudi S, Buchkovich ML, Wolford BN, Welch RP, Morken MA, Kwon GJ, Varshney A, Kursawe R, Wu Y, Jackson AU; Sequencing Program NISC Comparative, Erdos MR, Kuusisto J, Laakso M, Scott LJ, Boehnke M, Collins FS, Parker SCJ, Stitzel ML, Mohlke KL.

Diabetes. 2017 Jul 6. pii: db170464. doi: 10.2337/db17-0464. [Epub ahead of print]

PMID: 28684635

Complete Genome Sequences of 15 Chikungunya Virus Isolates from Puerto Rico.

Sanders WA, Long K, Rivera B, Vincent HA, Heise MT, Rodriguez-Orengo JF, Moorman NJ.

Genome Announc. 2017 Jul 6;5(27). pii: e00561-17. doi: 10.1128/genomeA.00561-17.

PMID: 28684571

SynthEx: a synthetic-normal-based DNA sequencing tool for copy number alteration detection and tumor heterogeneity profiling.

Silva GO, Siegel MB, Mose LE, Parker JS, Sun W, Perou CM, Chen M.

Genome Biol. 2017 Apr 8;18(1):66. doi: 10.1186/s13059-017-1193-3.

PMID: 28390427

Functional Transcriptomics in Diverse Intestinal Epithelial Cell Types Reveals Robust MicroRNA Sensitivity in Intestinal Stem Cells to Microbial Status.

Peck BC, Mah AT, Pitman WA, Ding S, Lund PK, Sethupathy P.

J Biol Chem. 2017 Feb 17;292(7):2586-2600. doi: 10.1074/jbc.M116.770099. Epub 2017 Jan 4.

PMID: 28053090

Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo.

Yang Y, Poe JC, Yang L, Fedoriw A, Desai S, Magnuson T, Li Z, Fedoriw Y, Araki K, Gao Y, Tateishi S, Sarantopoulos S, Vaziri C.

Nucleic Acids Res. 2016 May 19;44(9):4174-88. doi: 10.1093/nar/gkw072. Epub 2016 Feb 15.

PMID: 26883629

A population of G2-arrested cells are selected as sensory organ precursors for the interommatidial bristles of the Drosophila eye.

Meserve JH, Duronio RJ.

Dev Biol. 2017 Jun 20. pii: S0012-1606(16)30868-5. doi: 10.1016/j.ydbio.2017.06.023. [Epub ahead of print]

PMID: 28645749

Newborn Sequencing in Genomic Medicine and Public Health.

Berg JS, Agrawal PB, Bailey DB Jr, Beggs AH, Brenner SE, Brower AM, Cakici JA, Ceyhan-Birsoy O, Chan K, Chen F, Currier RJ, Dukhovny D, Green RC, Harris-Wai J, Holm IA, Iglesias B, Joseph G, Kingsmore SF, Koenig BA, Kwok PY, Lantos J, Leeder SJ, Lewis MA, McGuire AL, Milko LV, Mooney SD, Parad RB, Pereira S, Petrikin J, Powell BC, Powell CM, Puck JM, Rehm HL, Risch N, Roche M, Shieh JT, Veeraraghavan N, Watson MS, Willig L, Yu TW, Urv T, Wise AL.

Pediatrics. 2017 Feb;139(2). pii: e20162252. doi: 10.1542/peds.2016-2252. Epub 2017 Jan 17.

PMID: 28096516

Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16INK4a or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection.

Maas BM, Francis O, Mollan KR, Lee C, Cottrell ML, Prince HM, Sykes C, Trezza C, Torrice C, White N, Malone S, Hudgens MG, Sharpless NE, Dumond JB.

PLoS One. 2016 Dec 30;11(12):e0168709. doi: 10.1371/journal.pone.0168709. eCollection 2016.

PMID: 28036343

Transcriptomic comparison of Drosophila snRNP biogenesis mutants reveals mutant-specific changes in pre-mRNA processing: implications for spinal muscular atrophy.

Garcia EL, Wen Y, Praveen K, Matera AG.

RNA. 2016 Aug;22(8):1215-27. doi: 10.1261/rna.057208.116. Epub 2016 Jun 6.

PMID: 27268418