Department of Genetics faculty, postdocs, students and collaborators published eleven papers during May 31 – June 13, 2020.

 

Identification of type 2 diabetes loci in 433,540 East Asian individuals.
Spracklen CN, Horikoshi M, Kim YJ, Lin K, Bragg F, Moon S, Suzuki K, Tam CHT, Tabara Y, Kwak SH, Takeuchi F, Long J, Lim VJY, Chai JF, Chen CH, Nakatochi M, Yao J, Choi HS, Iyengar AK, Perrin HJ, Brotman SM, van de Bunt M, Gloyn AL, Below JE, Boehnke M, Bowden DW, Chambers JC, Mahajan A, McCarthy MI, Ng MCY, Petty LE, Zhang W, Morris AP, Adair LS, Akiyama M, Bian Z, Chan JCN, Chang LC, Chee ML, Chen YI, Chen YT, Chen Z, Chuang LM, Du S, Gordon-Larsen P, Gross M, Guo X, Guo Y, Han S, Howard AG, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Isono M, Jang HM, Jiang G, Jonas JB, Kamatani Y, Katsuya T, Kawaguchi T, Khor CC, Kohara K, Lee MS, Lee NR, Li L, Liu J, Luk AO, Lv J, Okada Y, Pereira MA, Sabanayagam C, Shi J, Shin DM, So WY, Takahashi A, Tomlinson B, Tsai FJ, van Dam RM, Xiang YB, Yamamoto K, Yamauchi T, Yoon K, Yu C, Yuan JM, Zhang L, Zheng W, Igase M, Cho YS, Rotter JI, Wang YX, Sheu WHH, Yokota M, Wu JY, Cheng CY, Wong TY, Shu XO, Kato N, Park KS, Tai ES, Matsuda F, Koh WP, Ma RCW, Maeda S, Millwood IY, Lee J, Kadowaki T, Walters RG, Kim BJ, Mohlke KL, Sim X.
Nature. 2020 May 6. doi: 10.1038/s41586-020-2263-3. [Epub ahead of print]
PMID: 32499647

 

Putative modulation of the gut microbiome by probiotics enhances preference for novelty in a preliminary double-blind placebo-controlled study in ferrets.
Dugyala S, Ptacek TS, Simon JM, Li Y, Fröhlich F.
Anim Microbiome. 2020;2. pii: 14. doi: 10.1186/s42523-020-00030-y. Epub 2020 May 5.
PMID: 32490353

 

mTADA is a framework for identifying risk genes from de novo mutations in multiple traits.
Nguyen TH, Dobbyn A, Brown RC, Riley BP, Buxbaum JD, Pinto D, Purcell SM, Sullivan PF, He X, Stahl EA.
Nat Commun. 2020 Jun 10;11(1):2929. doi: 10.1038/s41467-020-16487-z.
PMID: 32522981

 

The failure of two major formaldehyde catabolism enzymes (ADH5 and ALDH2) leads to partial synthetic lethality in C57BL/6 mice.
Nakamura J, Holley DW, Kawamoto T, Bultman SJ.
Genes Environ. 2020 Jun 3;42:21. doi: 10.1186/s41021-020-00160-4. eCollection 2020.
PMID: 32514323

 

Assessing exposure effects on gene expression.
Reifeis SA, Hudgens MG, Civelek M, Mohlke KL, Love MI.
Genet Epidemiol. 2020 Jun 8. doi: 10.1002/gepi.22324. [Epub ahead of print]
PMID: 32511796

 

Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes.
Katz DC, Aponte JD, Liu W, Green RM, Mayeux JM, Pollard KM, Pomp D, Munger SC, Murray SA, Roseman CC, Percival CJ, Cheverud J, Marcucio RS, Hallgrímsson B.
PLoS One. 2020 Jun 5;15(6):e0233377. doi: 10.1371/journal.pone.0233377. eCollection 2020.
PMID: 32502155

 

Temperature-sensitive spinal muscular atrophy-causing point mutations lead to SMN instability, locomotor defects and premature lethality in <i>Drosophila</i>.
Raimer AC, Singh SS, Edula MR, Paris-Davila T, Vandadi V, Spring AM, Matera AG.
Dis Model Mech. 2020 May 22;13(5). pii: dmm043307. doi: 10.1242/dmm.043307.
PMID: 32501283

 

Damage-responsive, maturity-silenced enhancers regulate multiple genes that direct regeneration in <i>Drosophila</i>.
Harris RE, Stinchfield MJ, Nystrom SL, McKay DJ, Hariharan IK.
Elife. 2020 Jun 3;9. pii: e58305. doi: 10.7554/eLife.58305. [Epub ahead of print]
PMID: 32490812

 

Reconstitution of the human tRNA splicing endonuclease complex: insight into the regulation of pre-tRNA cleavage.
Hayne CK, Schmidt CA, Haque MI, Matera AG, Stanley RE.
Nucleic Acids Res. 2020 Jun 1. pii: gkaa438. doi: 10.1093/nar/gkaa438. [Epub ahead of print]
PMID: 32476018

 

Pay-it-forward gonorrhoea and chlamydia testing among men who have sex with men in China: a randomised controlled trial.
Yang F, Zhang TP, Tang W, Ong JJ, Alexander M, Forastiere L, Kumar N, Li KT, Zou F, Yang L, Mi G, Wang Y, Huang W, Lee A, Zhu W, Luo D, Vickerman P, Wu D, Yang B, Christakis NA, Tucker JD.
Lancet Infect Dis. 2020 Apr 28. pii: S1473-3099(20)30172-9. doi: 10.1016/S1473-3099(20)30172-9. [Epub ahead of print]
PMID: 32530426

 

Fluent genomics with  <i>plyranges </i>and  <i>tximeta</i>.
Lee S, Lawrence M, Love MI.
F1000Res. 2020 Feb 12;9:109. doi: 10.12688/f1000research.22259.1. eCollection 2020.
PMID: 32528659