Department of Genetics Publications for Nov. 12-25, 2017

Department of Genetics faculty and collaborators published thirteen papers during Nov. 12-25, 2017.

Rapid DNA replication origin licensing protects stem cell pluripotency.

Matson JP, Dumitru R, Coryell P, Baxley RM, Chen W, Twaroski K, Webber BR, Tolar J, Bielinsky AK, Purvis JE, Cook JG.

Elife. 2017 Nov 17;6. pii: e30473. doi: 10.7554/eLife.30473. [Epub ahead of print]

PMID: 29148972

A Partial Loss-of-Function Variant in AKT2 is Associated with Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin Sensitive Tissues: a Genotype-Based Callback Positron Emission Tomography Study.

Latva-Rasku A, Honka MJ, Stančáková A, Koistinen HA, Kuusisto J, Guan L, Manning AK, Stringham H, Gloyn AL, Lindgren CM; T2D-GENES Consortium, Collins FS, Mohlke KL, Scott LJ, Karjalainen T, Nummenmaa L, Boehnke M, Nuutila P, Laakso M.

Diabetes. 2017 Nov 15. pii: db171142. doi: 10.2337/db17-1142. [Epub ahead of print]

PMID: 29141982

Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology.

Jones JE, Long KM, Whitmore AC, Sanders W, Thurlow LR, Brown JA, Morrison CR, Vincent H, Peck KM, Browning C, Moorman N, Lim JK, Heise MT.

MBio. 2017 Nov 14;8(6). pii: e01456-17. doi: 10.1128/mBio.01456-17.

PMID: 29138302

Genome-wide gene-environment interaction in depression: A systematic evaluation of candidate genes: The childhood trauma working-group of PGC-MDD.

Van der Auwera S, Peyrot WJ, Milaneschi Y, Hertel J, Baune B, Breen G, Byrne E, Dunn EC, Fisher H, Homuth G, Levinson D, Lewis C, Mills N, Mullins N, Nauck M, Pistis G, Preisig M, Rietschel M, Ripke S, Sullivan P, Teumer A, Völzke H; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Boomsma DI, Wray NR, Penninx B, Grabe H.

Am J Med Genet B Neuropsychiatr Genet. 2017 Nov 21. doi: 10.1002/ajmg.b.32593. [Epub ahead of print]

PMID: 29159863

A longitudinal study of DNA methylation as a potential mediator of age-related diabetes risk.

Grant CD, Jafari N, Hou L, Li Y, Stewart JD, Zhang G, Lamichhane A, Manson JE, Baccarelli AA, Whitsel EA, Conneely KN.

Geroscience. 2017 Nov 20. doi: 10.1007/s11357-017-0001-z. [Epub ahead of print]

PMID: 29159506

Improved ethical guidance for the return of results from psychiatric genomics research.

Lázaro-Muñoz G, Farrell MS, Crowley JJ, Filmyer DM, Shaughnessy RA, Josiassen RC, Sullivan PF.

Mol Psychiatry. 2017 Nov 21. doi: 10.1038/mp.2017.228. [Epub ahead of print]

PMID: 29158581

Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa.

Huckins LM, Hatzikotoulas K, Southam L, Thornton LM, Steinberg J, Aguilera-McKay F, Treasure J, Schmidt U, Gunasinghe C, Romero A, Curtis C, Rhodes D, Moens J, Kalsi G, Dempster D, Leung R, Keohane A, Burghardt R, Ehrlich S, Hebebrand J, Hinney A, Ludolph A, Walton E, Deloukas P, Hofman A, Palotie A, Palta P, van Rooij FJA, Stirrups K, Adan R, Boni C, Cone R, Dedoussis G, van Furth E, Gonidakis F, Gorwood P, Hudson J, Kaprio J, Kas M, Keski-Rahonen A, Kiezebrink K, Knudsen GP, Slof-Op ‘t Landt MCT, Maj M, Monteleone AM, Monteleone P, Raevuori AH, Reichborn-Kjennerud T, Tozzi F, Tsitsika A, van Elburg A; Eating Disorder Working Group of the Psychiatric Genomics Consortium, Collier DA, Sullivan PF, Breen G, Bulik CM, Zeggini E.

Mol Psychiatry. 2017 Jul 25. doi: 10.1038/mp.2017.88. [Epub ahead of print]

PMID: 29155802

Characterizing reduced coverage regions through comparison of exome and genome sequencing data across 10 centers.

Sanghvi RV, Buhay CJ, Powell BC, Tsai EA, Dorschner MO, Hong CS, Lebo MS, Sasson A, Hanna DS, McGee S, Bowling KM, Cooper GM, Gray DE, Lonigro RJ, Dunford A, Brennan CA, Cibulskis C, Walker K, Carneiro MO, Sailsbery J, Hindorff LA, Robinson DR, Santani A, Sarmady M, Rehm HL, Biesecker LG, Nickerson DA, Hutter CM, Garraway L, Muzny DM, Wagle N.

Genet Med. 2017 Nov 16. doi: 10.1038/gim.2017.192. [Epub ahead of print]

PMID: 29144510

Complete Genome Sequence of the Predatory Bacterium Ensifer adhaerens Casida A.

Williams LE, Baltrus DA, O’Donnell SD, Skelly TJ, Martin MO.

Genome Announc. 2017 Nov 22;5(47). pii: e01344-17. doi: 10.1128/genomeA.01344-17.

PMID: 29167262

Extensive Homeostatic T Cell Phenotypic Variation within the Collaborative Cross.

Graham JB, Swarts JL, Mooney M, Choonoo G, Jeng S, Miller DR, Ferris MT, McWeeney S, Lund JM.

Cell Rep. 2017 Nov 21;21(8):2313-2325. doi: 10.1016/j.celrep.2017.10.093.

PMID: 29166619

Enhancing Next-Generation Sequencing-Guided Cancer Care Through Cognitive Computing.

Patel NM, Michelini VV, Snell JM, Balu S, Hoyle AP, Parker JS, Hayward MC, Eberhard DA, Salazar AH, McNeillie P, Xu J, Huettner CS, Koyama T, Utro F, Rhrissorrakrai K, Norel R, Bilal E, Royyuru A, Parida L, Earp HS, Grilley-Olson JE, Hayes DN, Harvey SJ,Sharpless NE, Kim WY.

Oncologist. 2017 Nov 20. pii: theoncologist.2017-0170. doi: 10.1634/theoncologist.2017-0170. [Epub ahead of print]

PMID: 29158372

Functional Redundancy of Variant and Canonical Histone H3 Lysine 9 Modification in Drosophila.

Penke TJR, McKay DJ, Strahl BD, Matera AG, Duronio RJ.

Genetics. 2017 Nov 13. pii: genetics.300480.2017. doi: 10.1534/genetics.117.300480. [Epub ahead of print]

PMID: 29133298

Self-oligomerization regulates stability of Survival Motor Neuron (SMN) protein isoforms by sequestering an SCFSlmb degron.

Gray KM, Kaifer KA, Baillat D, Wen Y, Bonacci TR, Ebert AD, Raimer AC, Spring AM, Have ST, Glascock JJ, Gupta K, Van Duyne GD, Emanuele MJ, Lamond AI, Wagner EJ, Lorson CL, Matera AG.

Mol Biol Cell. 2017 Nov 22. pii: mbc.E17-11-0627. doi: 10.1091/mbc.E17-11-0627. [Epub ahead of print]

PMID: 29167380

More from Department of Genetics