Department of Genetics Publications for Oct. 1-14, 2017

Department of Genetics faculty and collaborators published twelve papers during the first two weeks of October 2017.

NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR.

Feng H, Lenarcic EM, Yamane D, Wauthier E, Mo J, Guo H, McGivern DR, González-López O, Misumi I, Reid LM, Whitmire JK, Ting JP, Duncan JA, Moorman NJ, Lemon SM.

Nat Immunol. 2017 Oct 2. doi: 10.1038/ni.3853. [Epub ahead of print]

PMID: 28967880

Generation and characterization of anti-Adeno-associated virus serotype 8 (AAV8) and anti-AAV9 monoclonal antibodies.

Tseng YS, Vliet KV, Rao L, McKenna R, Byrne BJ, Asokan A, Agbandje-McKenna M.

J Virol Methods. 2016 Oct;236:105-110. doi: 10.1016/j.jviromet.2016.07.009. Epub 2016 Jul 14.

PMID: 27424005

Whole-Genome Sequence Analysis of Mutations Accumulated in rad27Δ Yeast Strains with Defects in the Processing of Okazaki Fragments Indicates Template-Switching Events.

Omer S, Lavi B, Mieczkowski PA, Covo S, Hazkani-Covo E.

G3 (Bethesda). 2017 Oct 3. pii: g3.300262.2017. doi: 10.1534/g3.117.300262. [Epub ahead of print]

PMID: 28974572

Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer.

Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, Hinoue T, Laird PW, Hoadley KA, Akbani R, Castro MAA, Gibb EA, Kanchi RS, Gordenin DA, Shukla SA, Sanchez-Vega F, Hansel DE, Czerniak BA, Reuter VE, Su X, de Sa Carvalho B, Chagas VS, Mungall KL, Sadeghi S, Pedamallu CS, Lu Y, Klimczak LJ, Zhang J, Choo C, Ojesina AI, Bullman S, Leraas KM, Lichtenberg TM, Wu CJ, Schultz N, Getz G, Meyerson M, Mills GB, McConkey DJ; TCGA Research Network, Weinstein JN, Kwiatkowski DJ, Lerner SP.

Cell. 2017 Oct 4. pii: S0092-8674(17)31056-5. doi: 10.1016/j.cell.2017.09.007. [Epub ahead of print]

PMID: 28988769

Clinical outcomes in idursulfase-treated patients with mucopolysaccharidosis type II: 3-year data from the hunter outcome survey (HOS).

Muenzer J, Giugliani R, Scarpa M, Tylki-Szymańska A, Jego V, Beck M.

Orphanet J Rare Dis. 2017 Oct 3;12(1):161. doi: 10.1186/s13023-017-0712-3.

PMID: 28974237

Citizen science or scientific citizenship? Disentangling the uses of public engagement rhetoric in national research initiatives.

Woolley JP, McGowan ML, Teare HJ, Coathup V, Fishman JR, Settersten RA Jr, Sterckx S, Kaye J, Juengst ET.

BMC Med Ethics. 2016 Jun 4;17(1):33. doi: 10.1186/s12910-016-0117-1.

PMID: 27260081

Adrenomedullin Improves Fertility and Promotes Pinopodes and Cell Junctions in the Peri-Implantation Endometrium.

Matson BC, Pierce SL, Espenschied ST, Holle E, Sweatt IH, Davis ES, Tarran R, Young SL, Kohout TA, van Duin M, Caron KM.

Biol Reprod. 2017 Aug 28. doi: 10.1093/biolre/iox101. [Epub ahead of print]

PMID: 29025060

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia.

Li Z, Chen J, Yu H, He L, Xu Y, Zhang D, Yi Q, Li C, Li X, Shen J, Song Z, Ji W, Wang M, Zhou J, Chen B, Liu Y, Wang J, Wang P, Yang P, Wang Q, Feng G, Liu B, Sun W, Li B, He G, Li W, Wan C, Xu Q, Li W, Wen Z, Liu K, Huang F, Ji J, Ripke S, Yue W, Sullivan PF, O’Donovan MC, Shi Y.

Nat Genet. 2017 Oct 9. doi: 10.1038/ng.3973. [Epub ahead of print]

PMID: 28991256

Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis.

Kennedy L, Kaltenbrun E, Greco TM, Temple B, Herring LE, Cristea IM, Conlon FL.

PLoS Genet. 2017 Sep 25;13(9):e1007011. doi: 10.1371/journal.pgen.1007011. eCollection 2017 Sep.

PMID: 28945738

Static and Dynamic DNA Loops form AP-1-Bound Activation Hubs during Macrophage Development.

Phanstiel DH, Van Bortle K, Spacek D, Hess GT, Shamim MS, Machol I, Love MI, Aiden EL, Bassik MC, Snyder MP.

Mol Cell. 2017 Sep 21;67(6):1037-1048.e6. doi: 10.1016/j.molcel.2017.08.006. Epub 2017 Sep 7.

PMID: 28890333

Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells.

Lickwar CR, Camp JG, Weiser M, Cocchiaro JL, Kingsley DM, Furey TS, Sheikh SZ, Rawls JF.

PLoS Biol. 2017 Aug 29;15(8):e2002054. doi: 10.1371/journal.pbio.2002054. eCollection 2017 Aug.

PMID: 28850571

Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation?

Raffield LM, Louie T, Sofer T, Jain D, Ipp E, Taylor KD, Papanicolaou GJ, Avilés-Santa L, Lange LA, Laurie CC, Conomos MP, Thornton TA, Chen YI, Qi Q, Cotler S, Thyagarajan B, Schneiderman N, Rotter JI, Reiner AP, Lin HJ.

Hum Mol Genet. 2017 May 15;26(10):1966-1978. doi: 10.1093/hmg/ddx082.

PMID: 28334935