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Adam J. Kimple, MD, PhD

Associate Professor

Specialty Areas:

Rhinology, Allergy, Skull Base Surgery, Otolaryngology and Sinusitis

Chronology:

BS Chemistry, Michigan State University, 2003; MS Computational Chemistry, Michigan State University, 2003; MD/PhD University of North Carolina, 2012, Residency in Otolaryngology/Head and Neck Surgery – 2012-2017; Fellowship in Rhinology, Allergy and Skull Base Surgery 2017-2018; Assistant Professor in Rhinology, Allergy and Skull Base Surgery 2018-present.

Selected Publications:

  1. Worden CP, Hicks KB, Hackman TG, Yarbrough WG, Kimple AJ, Farzal Z. The Toxicological Effects of e-Cigarette Use in the Upper Airway: A Scoping Review. Otolaryngol Head Neck Surg. 2024 Feb 14. doi: 10.1002/ohn.652. Epub ahead of print. PMID: 38353408.
  2. Liu CM, Han EJ, Fischer JL, Mace JC, Mattos JL, Markarian K, Alt JA, Bodner TE, Chowdhury NI, Eshaghian PH, Getz AE, Hwang PH, Khanwalkar A, Kimple AJ, Lee JT, Li DA, Norris M, Nayak JV, Owens C, Patel ZM, Poch K, Schlosser RJ, Smith KA, Smith TL, Soler ZM, Suh JD, Turner GA, Wang MB, Taylor-Cousar JL, Saavedra MT, Beswick DM. Patient perspectives on chronic rhinosinusitis in cystic fibrosis: Symptom prioritization in the era of highly effective modulator therapy. Int Forum Allergy Rhinol. 2024 Feb 11. doi: 10.1002/alr.23332. Epub ahead of print. PMID: 38343143.
  3. Monk A, Thorp BD, Senior BA, Kimple AJ, Klatt-Cromwell C, Ebert CS Jr. Ensuring the appropriate use of biologics: A call for specialty evaluation. Int Forum Allergy Rhinol. 2024 Feb 11. doi: 10.1002/alr.23333. Epub ahead of print. PMID: 38343308.
  4. Miller JE, Taylor-Cousar JL, Overdevest JB, Khatiwada A, Mace JC, Alt JA, Bodner TE, Chowdhury NI, DiMango EA, Eshaghian PH, Getz AE, Gudis DA, Han EJ, Hwang PH, Keating CL, Khanwalkar A, Kimple AJ, Lee JT, Li D, Markarian K, Norris M, Nayak JV, Owens C, Patel ZM, Poch K, Schlosser RJ, Smith KA, Smith TL, Soler ZM, Suh JD, Tervo JP, Turner GA, Wang MB, Saavedra MT, Beswick DM. Determining the minimal clinically important difference for the questionnaire of olfactory disorders in people with cystic fibrosis and factors associated with improvement after highly effective modulator therapy. Int Forum Allergy Rhinol. 2023 Dec 25. doi: 10.1002/alr.23312. Epub ahead of print. PMID: 38145393.
  5. Kim S, Li L, Lin FC, Stack T, Lamb MM, Mohammad I, Norris M, Klatt-Cromwell C, Thorp BD, Ebert CS Jr, Masters D, Senior BA, Askin FB, Kimple AJ. Histologic characterization of primary ciliary dyskinesia chronic rhinosinusitis. Int Forum Allergy Rhinol. 2023 Nov 23. doi: 10.1002/alr.23303. Epub ahead of print. PMID: 37997295.
  6. Stack T, Norris M, Kim S, Lamb M, Zeatoun A, Mohammad I, Worden C, Thorp BD, Klatt-Cromwell C, Ebert CS Jr, Senior BA, Kimple AJ. Sinonasal quality of life in primary ciliary dyskinesia. Int Forum Allergy Rhinol. 2023 Nov;13(11):2101-2104. doi: 10.1002/alr.23180. PMID: 37203268.
  7. Zemke AC, Hilliam Y, Stapleton AL, Kimple AJ, Goralski JL, Shaffer AD, Pilewski JM, Senior BA, Lee SE, Cooper VS. Elexacaftor-tezacaftor-ivacaftor decreases pseudomonas abundance in the sinonasal microbiome in cystic fibrosis. Int Forum Allergy Rhinol. 2023 Oct 14. doi: 10.1002/alr.23288. Epub ahead of print. PMID: 37837613.
  8. Lamb MM, DeHority K, Russel SM, Kim S, Stack T, Mohammad I, Zeatoun A, Klatt-Cromwell C, Ebert CS Jr, Baratta JM, Senior BA, Kimple AJ. Characteristics of olfactory dysfunction in patients with long-haul covid-19. Rhinol Online. 2023;6:30-37.PMID: 37711977; PMCID: PMC10501207.
  9. Chaskes MB, Lopez EM, Kong KA, Ebert CS Jr, Senior BA, Thorp BD, Kimple AJ. Primary ciliary dyskinesia: An update on contemporary diagnosis. Int Forum Allergy Rhinol. 2023 Aug 11. doi: 10.1002/alr.23254. Epub ahead of print. PMID: 37565263.
  10. Yin W, Golliher HL, Ferguson AJ, Kimbell JS, Livraghi-Butrico A, Rogers TD, Grubb BR, Kimple AJ, Ostrowski LE. Mucolytic treatment of chronic rhinosinusitis in a murine model of primary ciliary dyskinesia. Front Mol Biosci. 2023 Jul 24;10:1221796. doi: 10.3389/fmolb.2023.1221796. PMID: 37555015; PMCID: PMC10405821.
  11. Rebuli ME, Stanley Lee A, Nurhussien L, Tahir UA, Sun WY, Kimple AJ, Ebert CS Jr, Almond M, Jaspers I, Rice MB. Nasal biomarkers of immune function differ based on smoking and respiratory disease status. Physiol Rep. 2023 Feb;11(3):e15528. doi: 10.14814/phy2.15528. PMID: 36780897; PMCID: PMC9925276.
  12. Lee SE, Ghodke AN, Stepp WH, Kong KA, Chaskes M, Quinsey CS, Ebert CS Jr, Thorp BD, Senior BA, Kimple AJ. Sinonasal complications of severe acute respiratory syndrome coronavirus-2: A single center case series. Laryngoscope Investig Otolaryngol. 2023 Jan 19;8(1):16-24. doi: 10.1002/lio2.1006. PMID: 36846423; PMCID: PMC9948594.
  13. Lee RE, Lewis CA, He L, Bulik-Sullivan EC, Gallant SC, Mascenik TM, Dang H, Cholon DM, Gentzsch M, Morton LC, Minges JT, Theile JW, Castle NA, Knowles MR, Kimple AJ, Randell SH. Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough. J Clin Invest. 2022 Sep 15;132(18):e154571. doi: 10.1172/JCI154571. PMID: 35900863; PMCID: PMC9479597.
  14. Esther CR Jr, Kimura KS, Mikami Y, Edwards CE, Das SR, Freeman MH, Strickland BA, Brown HM, Wessinger BC, Gupta VC, Von Wahlde K, Sheng Q, Huang LC, Bacon DR, Kimple AJ, Ceppe AS, Kato T, Pickles RJ, Randell SH, Baric RS, Turner JH, Boucher RC. Pharmacokinetic-based failure of a detergent virucidal for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) nasal infections: A preclinical study and randomized controlled trial. Int Forum Allergy Rhinol. 2022 Sep;12(9):1137-1147. doi: 10.1002/alr.22975. PMID: 35040594. PMCID: PMC9011886.
  15. Kimple AJ, Senior BA, Naureckas ET, Gudis DA, Meyer T, Hempstead SE, Resnick HE, Albon D, Barfield W, Benoit MM, Beswick DM, Callard E, Cofer S, Downer V, Elson EC, Garinis A, Halderman A, Hamburger L, Helmick M, McCown M, McKinzie C, Phan H, Rodriguez K, Rubenstein RC, Severin A, Shah G, Shenoy A, Sprouse B, Virgin F, Woodworth BA, Lee SE. Cystic fibrosis foundation otolaryngology care multidisciplinary consensus recommendations. Int Forum Allergy Rhinol. 2022 Sep;12(9):1089-1103. doi: 10.1002/alr.22974. PMID: 35089650. PMCID: PMC9545592.
  16. Spielman DB, Beswick DM, Kimple AJ, Senior BA, Aanaes K, Woodworth BA, Schlosser RJ, Lee S, Cho DY, Adappa ND, DiMango E, Gudis DA. The management of cystic fibrosis chronic rhinosinusitis: An evidenced-based review with recommendations. Int Forum Allergy Rhinol. 2022 Sep;12(9):1148-1183. doi: 10.1002/alr.22953. PMID: 34933415.
  17. Stapleton AL, Kimple AJ, Goralski JL, Nouraie SM, Branstetter BF, Shaffer AD, Pilewski JM, Senior BA, Lee SE, Zemke AC. Elexacaftor-Tezacaftor- Ivacaftor improves sinonasal outcomes in cystic fibrosis. J Cyst Fibros. 2022 Sep;21(5):792-799. doi: 10.1016/j.jcf.2022.03.002. PMID: 35300931. PMCID: PMC9470769.
  18. Hill CJ, Meyer CD, McLean JE, Anderson DC, Hao Y, Lin FC, Kimple AJ, Capra GG. Burn pit exposure is associated with increased sinonasal disease. J Occup Environ Med. 2022 Aug 1;64(8):629-634. doi: 10.1097/JOM.0000000000002551. PMID: 35673272. PMCID: PMC9357047.
  19. Bacon DR, Stapleton A, Goralski JL, Ebert CS Jr, Thorp BD, Nouraie M, Shaffer AD, Senior BA, Lee SE, Zemke AC, Kimple AJ. Olfaction before and after initiation of elexacaftor-tezacaftor-ivacaftor in a cystic fibrosis cohort. Int Forum Allergy Rhinol. 2022 Feb;12(2):223-226. doi: 10.1002/alr.22891.PMID: 34709729; PMCID: PMC8792160.
  20. Bacon DR, Onuorah P, Murr A, Wiesen CA, Oakes J, Thorp BD, Zanation AM, Ebert CS Jr, Wohl D, Senior BA, Kimple AJ. COVID-19 related olfactory dysfunction prevalence and natural history in ambulatory patients. Rhinol Online. 2021;4(4):131-139. doi: 10.4193/rhinol/21.034. PMID: 34485883; PMCID: PMC8415759.
  21. Murr A, Lenze NR, Brown WC, Gelpi MW, Ebert CS Jr, Senior BA, Thorp BD, Zanation AM, Kimple AJ. Quantification of Aerosol Particle Concentrations During Endoscopic Sinonasal Surgery in the Operating Room. Am J Rhinol Allergy. 2021 Jul;35(4):426-431. doi: 10.1177/1945892420962335. PMID: 33012174. PMCID: PMC8822194.
  22. Huang N, Pérez P, Kato T, Mikami Y, Okuda K, Gilmore RC, Conde CD, Gasmi B, Stein S, Beach M, Pelayo E, Maldonado JO, Lafont BA, Jang SI, Nasir N, Padilla RJ, Murrah VA, Maile R, Lovell W, Wallet SM, Bowman NM, Meinig SL, Wolfgang MC, Choudhury SN, Novotny M, Aevermann BD, Scheuermann RH, Cannon G, Anderson CW, Lee RE, Marchesan JT, Bush M, Freire M, Kimple AJ, Herr DL, Rabin J, Grazioli A, Das S, French BN, Pranzatelli T, Chiorini JA, Kleiner DE, Pittaluga S, Hewitt SM, Burbelo PD, Chertow D; NIH COVID-19 Autopsy Consortium; HCA Oral and Craniofacial Biological Network, Frank K, Lee J, Boucher RC, Teichmann SA, Warner BM, Byrd KM. SARS-CoV-2 infection of the oral cavity and saliva. Nat Med. 2021 May;27(5):892-903. doi: 10.1038/s41591-021-01296-8. PMID: 33767405. PMCID: PMC8240394.
  23. Murr AT, Lenze NR, Gelpi MW, Brown WC, Ebert CS Jr, Senior BA, Thorp BD, Kimple AJ, Zanation AM. Quantification of Aerosol Concentrations During Endonasal Instrumentation in the Clinic Setting. Laryngoscope. 2021 May;131(5):E1415-E1421. doi: 10.1002/lary.29122. PMID: 33017067; PMCID: PMC7675733.
  24. Pappa AK, Sullivan KM, Lopez EM, Adams KN, Zanation AM, Ebert CS Jr, Thorp BD, Senior BA, Leigh MW, Knowles MR, Kimple AJ. Sinus Development and Pneumatization in a Primary Ciliary Dyskinesia Cohort. Am J Rhinol Allergy. 2021 Jan;35(1):72-76. doi: 10.1177/1945892420933175. PMID: 32551925. PMCID: PMC7750665.
  25. Hou YJ, Okuda K, Edwards CE, Martinez DR, Asakura T, Dinnon III KH, Kato T, Lee RE, Yount BL, Mascenik TM, Chen G, Olivier KN, Ghio A, Tse LV, Leist SR, Gralinski LE, Schäfer A, Dang H, Gilmore R, Fulcher L, Livraghi-Butrico A, Nicely NI, Cameron M, Cameron C, Kelvin DJ, de Silva A, Margolis DM, Markmann A, Bartelt L, Zumwalt R, Martinez FJ, Salvatore SP, Borczuk A, Tata PR, Sontake V, Kimple A, Jaspers I, O’Neal WK, Randell SH, Boucher RC, Baric RS. SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract. Cell. 2020 Jul 23;182(2):429-446.e14. doi: 10.1016/j.cell.2020.05.042. PMID: 32386347; PMCID: PMC7425176.
  26. Lee SE, Farzal Z, Daniels MLA, Thorp BD, Zanation AM, Senior BA, Ebert CS Jr, Kimple AJ. Cystic Fibrosis Transmembrane Conductance Regulator Modulator Therapy: A Review for the Otolaryngologist. Am J Rhinol Allergy. 2020 Jul;34(4):573-580. doi: 10.1177/1945892420912368. PMID: 32168995. PMCID: PMC7573678.
  27. Basu S, Holbrook LT, Kudlaty K, Fasanmade O, Wu J, Burke A, Langworthy BW, Farzal Z, Mamdani M, Bennett WD, Fine JP, Senior BA, Zanation AM, Ebert CS Jr, Kimple AJ, Thorp BD, Frank-Ito DO, Garcia GJM, Kimbell JS. Numerical evaluation of spray position for improved nasal drug delivery. Sci Rep. 2020 Jun 29;10(1):10568. doi: 10.1038/s41598-020-66716-0. PMID: 32601278; PMCID: PMC7324389.
  28. Farzal Z, Dean KM, Sreenath SB, Hodge SE, Thorp BD, Ebert CS Jr, Zanation AM, Senior BA, Kimple AJ. Streamlining care in cystic fibrosis: survey of otolaryngologist, pulmonologist, and patient experiences. Int Forum Allergy Rhinol. 2020 May;10(5):591-603. doi: 10.1002/alr.22522. PMID: 31951081. PMCID: PMC7278084.
  29. Nguyen TT, Soma PS, Mascenik T, Lewis CA, Lee RE, Thorp BD, Zanation AM, Ebert CS Jr, Senior BA, Randell SH, Ehrmann BM, Kimple AJ. Mometasone absorption in cultured airway epithelium. Int Forum Allergy Rhinol. 2019 Dec;9(12):1451-1455. doi: 10.1002/alr.22441. PMID: 31633879. PMCID: PMC6927533.
  30. Farzal Z, Perry MF, Yarbrough WG, Kimple AJ. The Adolescent Vaping Epidemic in the United States-How It Happened and Where We Go From Here. JAMA Otolaryngol Head Neck Surg. 2019 Oct 1;145(10):885-886. doi: 10.1001/jamaoto.2019.2410. PMID: 31436792.
  31. Shapiro AJ, Zariwala MA, Ferkol T, Davis SD, Sagel SD, Dell SD, Rosenfeld M, Olivier KN, Milla C, Daniel SJ, Kimple AJ, Manion M, Knowles MR, Leigh MW; Genetic Disorders of Mucociliary Clearance Consortium. Diagnosis, monitoring, and treatment of primary ciliary dyskinesia: PCD foundation consensus recommendations based on state of the art review. Pediatr Pulmonol. 2016 Feb;51(2):115-32. doi: 10.1002/ppul.23304. PMID: 26418604.
  32. Kimple AJ, Garland AL, Cohen SP, Setola V, Willard FS, Zielinski T, Lowery RG, Tarran R, Siderovski DP. RGS21, a regulator of taste and mucociliary clearance? Laryngoscope. 2014 Mar;124(3):E56-63. doi: 10.1002/lary.24326. PMID: 23908053.
  33. Wallace IF, Berkman ND, Lohr KN, Harrison MF, Kimple AJ, Steiner MJ. Surgical treatments for otitis media with effusion: a systematic review. Pediatrics. 2014 Feb;133(2):296-311. doi: 10.1542/peds.2013-3228. PMID: 24394689.
  34. Kimple AJ, Ishman SL. Allergy and sleep-disordered breathing. Curr Opin Otolaryngol Head Neck Surg. 2013 Jun;21(3):277-81. doi: 10.1097/MOO.0b013e32835ff132. PMID: 23619424.
  35. Cohen SP, Buckley BK, Kosloff M, Garland AL, Bosch DE, Cheng G Jr, Radhakrishna H, Brown MD, Willard FS, Arshavsky VY, Tarran R, Siderovski DP, Kimple AJ. Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. J Biol Chem. 2012 Dec 7;287(50):41706-19. doi: 10.1074/jbc.M112.423806. PMID: 23095746.

Click here for a more complete list of published works (PubMed).

Adam Kimple

  • Phone Number

    (919) 966-3342 (Office Phone)

  • Address

    170 Manning Drive, CB#7070

    Physicians Office Bldg Rm G190, UNC Dept of Otolaryngology

    Chapel Hill, NC 27599-7070