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Michael Rubinstein, PhD

 Recent Publications:

  1. Chen D, Panyukov S, Sapir L, Rubinstein M. Elasticity of Slide-Ring Gels. ACS Macro Lett. 2023 Feb 24:362-368. doi: 10.1021/acsmacrolett.3c00010. Epub ahead of print. PMID: 36826840.
  2. Hill DB, Button B, Rubinstein M, Boucher RC. Physiology and Pathophysiology of Human Airway Mucus. Physiol Rev. 2022 Oct 1;102(4):1757-1836. doi: 10.1152/physrev.00004.2021. PMID: 35001665. PMCID: PMC9665957. https://journals.physiology.org/doi/abs/10.1152/physrev.00004.2021
  3. Li Y, Li Y, Prince E, Weitz JI, Panyukov S, Ramachandran A, Rubinstein M, Kumacheva E. Fibrous hydrogels under biaxial confinement. Nat Commun. 2022 Jun 7;13(1):3264. doi: 10.1038/s41467-022-30980-7. PMID: 35672320; PMCID: PMC9174476. https://www.nature.com/articles/s41467-022-30980-7
  4. Bilchak CR, Jhalaria M, Adhikari S, Midya J, Huang Y, Abbas Z, Nikoubashman A, Benicewicz BC, Rubinstein M, Kumar SK. Understanding Gas Transport in Polymer-Grafted Nanoparticle Assemblies. Macromolecules. 2022 Apr 6;55(8):3011-9. doi: 10.1021/acs.macromol.1c02367. PMID: 35978703. PMCID: PMC9377655. https://pubs.acs.org/doi/full/10.1021/acs.macromol.1c02367
  5. Kato T, Radicioni G, Papanikolas MJ, Stoychev GV, Markovetz MR, Aoki K, Porterfield M, Okuda K, Barbosa Cardenas SM, Gilmore RC, Morrison CB, Ehre C, Burns KA, White KK, Brennan TA, Goodell HP, Thacker H, Loznev HT, Forsberg LJ, Nagase T, Rubinstein M, Randell SH, Tiemeyer M, Hill DB, Kesimer M, O’Neal WK, Ballard ST, Freeman R, Button B, Boucher RC. Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis. Sci Adv. 2022 Apr;8(13):eabm9718. doi: 10.1126/sciadv.abm9718. PMID: 35363522. https://www.science.org/doi/10.1126/sciadv.abm9718
  6. Tang Q, Rubinstein M. Where in the world are condensed counterions? Soft Matter. 2022 Feb 9;18(6):1154-1173. doi: 10.1039/d1sm01494c. PMID: 35024721. PMCID: PMC8965743. https://pubs.rsc.org/en/content/articlelanding/2022/SM/D1SM01494C
  7. Parisi D, Buenning E, Kalafatakis N, Gury L, Benicewicz BC, Gauthier M, Cloitre M, Rubinstein M, Kumar SK, Vlassopoulos D. Universal Polymeric-to-Colloidal Transition in Melts of Hairy Nanoparticles. ACS Nano. 2021 Oct 26;15(10):16697-16708. doi: 10.1021/acsnano.1c06672. PMID: 34623796. PMCID: PMC8905532. PMCID: PMC8905532. https://pubs.acs.org/doi/10.1021/acsnano.1c06672
  8. Wang Z, Zheng X, Ouchi T, Kouznetsova TB, Beech HK, Av-Ron S, Matsuda T, Bowser BH, Wang S, Johnson JA, Kalow JA, Olsen BD, Gong JP, Rubinstein M, Craig SL. Toughening hydrogels through force-triggered chemical reactions that lengthen polymer strands. Science. 2021 Oct 8;374(6564):193-196. doi: 10.1126/science.abg2689. PMID: 34618576. https://www.science.org/doi/10.1126/science.abg2689
  9. Wang J, O’Connor TC, Grest GS, Zheng Y, Rubinstein M, Ge T. Diffusion of Thin Nanorods in Polymer Melts. Macromolecules. 2021 Aug 10;54(15):7051-7059. doi: 10.1021/acs.macromol.1c00989. PMID: 35935463; PMCID: PMC9347642. https://pubs.acs.org/doi/abs/10.1021/acs.macromol.1c00989
  10. Parisi D, Kaliva M, Costanzo S, Huang Q, Lutz PJ, Ahn J, Chang T, Rubinstein M, Vlassopoulos D. Nonlinear rheometry of entangled polymeric rings and ring-linear blends. J Rheol. 2021 Jul 21;65(4):695-711. doi: 10.1122/8.0000186. PMID: 35250122;
    PMCID: PMC8896906. https://sor.scitation.org/doi/full/10.1122/8.0000186
  11. Adhikari S, Nikoubashman A, Leibler L, Rubinstein M, Midya J, Kumar SK. Gas Transport in Interacting Planar Brushes. ACS Polymers Au. 2021 May 27;1:39-46. doi: 10.1021/acspolymersau.1c00006. PMID: 35253005; PMCID: PMC8896898. https://pubs.acs.org/doi/abs/10.1021/acspolymersau.1c00006
  12. Danielsen SPO, Beech HK, Wang S, El-Zaatari BM, Wang X, Sapir L, Ouchi T, Wang Z, Johnson PN, Hu Y, Lundberg DJ, Stoychev G, Craig SL, Johnson JA, Kalow JA, Olsen BD, Rubinstein M. Molecular Characterization of Polymer Networks. Chem Rev. 2021 Apr 28;121(8):5042-5092. doi: 10.1021/acs.chemrev.0c01304. PMID: 33792299. https://pubs.acs.org/doi/10.1021/acs.chemrev.0c01304
  13. Bowser BH, Wang S, Kouznetsova TB, Beech HK, Olsen BD, Rubinstein M, Craig SL. Single-Event Spectroscopy and Unravelling Kinetics of Covalent Domains Based on Cyclobutane Mechanophores. J Am Chem Soc. 2021 Apr 7;143(13):5269-5276. doi: 10.1021/jacs.1c02149. PMID: 33783187. https://pubs.acs.org/doi/10.1021/jacs.1c02149
  14. Wang S, Beech HK, Bowser BH, Kouznetsova TB, Olsen BD, Rubinstein M, Craig SL. Mechanism Dictates Mechanics: A Molecular Substituent Effect in the Macroscopic Fracture of a Covalent Polymer Network. J Am Chem Soc. 2021 Mar 17;143(10):3714-3718. doi: 10.1021/jacs.1c00265. PMID: 33651599. https://pubs.acs.org/doi/10.1021/jacs.1c00265
  15. Aponte-Rivera C, Rubinstein M. Dynamic Coupling in Unentangled Liquid Coacervates Formed by Oppositely Charged Polyelectrolytes. Macromolecules. 2021 Feb 23;54(4):1783-1800. doi: 10.1021/acs.macromol.0c01393. PMID: 33981120; PMCID: PMC8109663. https://pubs.acs.org/doi/abs/10.1021/acs.macromol.0c01393
  16. Midya J, Rubinstein M, Kumar SK, Nikoubashman A. Structure of Polymer-Grafted Nanoparticle Melts. ACS Nano. 2020 Nov 24;14(11):15505-15516. doi: 10.1021/acsnano.0c06134. PMID: 33084300; PMCID: PMC8056455. https://pubs.acs.org/doi/10.1021/acsnano.0c06134
  17. Bilchak CR, Jhalaria M, Huang Y, Abbas Z, Midya J, Benedetti FM, Parisi D, Egger W, Dickmann M, Minelli M, Doghieri F, Nikoubashman A, Durning CJ, Vlassopoulos D, Jestin J, Smith ZP, Benicewicz BC, Rubinstein M, Leibler L, Kumar SK. Tuning Selectivities in Gas Separation Membranes Based on Polymer-Grafted Nanoparticles. ACS Nano. 2020 Nov 20. doi: 10.1021/acsnano.0c07049. Epub ahead of print. PMID: 33216546. https://pubs.acs.org/doi/10.1021/acsnano.0c07049
  18. Danielsen SPO, Panyukov S, Rubinstein M. Ion Pairing and the Structure of Gel Coacervates. Macromolecules. 2020 Nov 10;53(21):9420-9442. doi: 10.1021/acs.macromol.0c01360. PMID: 34366486; PMCID: PMC8340939. https://pubs.acs.org/doi/abs/10.1021/acs.macromol.0c01360
  19. Ge T, Rubinstein M, Grest GS. Effects of Tethered Polymers on Dynamics of Nanoparticles in Unentangled Polymer Melts. Macromolecules. 2020 Aug 25;53(16):6898-6906. doi: 10.1021/acs.macromol.9b01921. PMID: 34366485; PMCID: PMC8341439. https://pubs.acs.org/doi/abs/10.1021/acs.macromol.9b01921
  20. Morhard R, Mueller JL, Tang Q, Nief C, Chelales E, Lam CT, Alvarez DA, Rubinstein M, Katz DF, Ramanujam N. Understanding Factors Governing Distribution Volume of Ethyl Cellulose-Ethanol to Optimize Ablative Therapy in the Liver. IEEE Trans Biomed Eng. 2020 Aug;67(8):2337-2348. doi: 10.1109/TBME.2019.2960049. PMID: 31841399; PMCID: PMC7295656. https://ieeexplore.ieee.org/abstract/document/8933449
  21. Parisi D, Ahn J, Chang T, Vlassopoulos D, Rubinstein M. Stress relaxation in symmetric ring-linear polymer blends at low ring fractions. Macromolecules. 2020 Mar 10;53(5):1685-1693. doi: 10.1021/acs.macromol.9b02536. PMID: 33518807; PMCID: PMC7839933. https://pubs.acs.org/doi/abs/10.1021/acs.macromol.9b02536
  22. O’Connor TC, Ge T, Rubinstein M, Grest GS. Topological Linking Drives Anomalous Thickening of Ring Polymers in Weak Extensional Flows. Phys Rev Lett. 2020 Jan 17;124(2):027801. doi: 10.1103/PhysRevLett.124.027801. PMID: 32004030; PMCID: PMC7190399. https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.124.027801
  23. Huang Q, Ahn J, Parisi D, Chang T, Hassager O, Panyukov S, Rubinstein M, Vlassopoulos D. Unexpected Stretching of Entangled Ring Macromolecules. Phys Rev Lett. 2019 May 24;122(20):208001. doi: 10.1103/PhysRevLett.122.208001. PMID: 31172770; PMCID: PMC6778440. https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.122.208001
  24. Wang S, Panyukov S, Rubinstein M, Craig SL. Quantitative Adjustment to the Molecular Energy Parameter in the Lake–Thomas Theory of Polymer Fracture Energy. Macromolecules. 2019 Mar 21;52:2772-2777. doi: 10.1021/acs.macromol.8b02341. https://pubs.acs.org/doi/abs/10.1021/acs.macromol.8b02341
  25. Galati E, Tao H, Tebbe M, Ansari R, Rubinstein M, Zhulina EB, Kumacheva E. Helicoidal Patterning of Nanorods with Polymer Ligands. Angew Chem Int Ed Engl. 2019 Mar 4;58(10):3123-3127. doi: 10.1002/anie.201812887. PMID: 30604462; PMCID: PMC6400493. https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201812887
  26. Ge T, Rubinstein M. Mobility of Polymer-Tethered Nanoparticles in Unentangled Polymer Melts. Macromolecules. 2019 Feb 26;52(4):1536-1545. doi: 10.1021/acs.macromol.8b02138. PMID: 30956355; PMCID: PMC6449055. https://www.ncbi.nlm.nih.gov/pubmed/30956355
  27. Rubinstein M, Liao Q, Panyukov S. Structure of Liquid Coacervates formed by Oppositely Charged Polyelectrolytes. Macromolecules. 2018 Dec 11;51(23):9572-9588. doi: 10.1021/acs.macromol.8b02059. PMID: 30853717; PMCID: PMC6402498. https://pubs.acs.org/doi/abs/10.1021/acs.macromol.8b02059
  28. Button B, Goodell HP, Atieh E, Chen YC, Williams R, Shenoy S, Lackey E, Shenkute NT, Cai LH, Dennis RG, Boucher RC, Rubinstein M. Roles of mucus adhesion and cohesion in cough clearance. Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12501-12506. doi: 10.1073/pnas.1811787115. PMID: 30420506; PMCID: PMC6298066. https://www.pnas.org/content/pnas/115/49/12501.full.pdf
  29. Shi R, Sun TL, Luo F, Nakajima T, Kurokawa T, Bin YZ, Rubinstein M, Gong JP. Elastic-Plastic Transformation of Polyelectrolyte Complex Hydrogels from Chitosan and Sodium Hyaluronate. Macromolecules. 2018 Nov 13;51(21):8887-8898. doi: 10.1021/acs.macromol.8b01658. PMID: 30956354; PMCID: PMC6449056. https://pubs.acs.org/doi/abs/10.1021/acs.macromol.8b01658
  30. Wagner CE, Turner BS, Rubinstein M, McKinley GH, Ribbeck K. A Rheological Study of the Association and Dynamics of MUC5AC Gels. Biomacromolecules. 2017 Nov 13;18(11):3654-3664. doi: 10.1021/acs.biomac.7b00809. PMID: 28903557; PMCID: PMC5776034. http://www.pnas.org/content/early/2017/04/27/1701132114
  31. Peters BL, Pike DQ, Rubinstein M, Grest GS. Polymers at Liquid/Vapor Interface. ACS Macro Lett. 2017 Oct 11;6(11):1191-1195. doi: 10.1021/acsmacrolett.7b00466. PMID: 29226024; PMCID: PMC5718204. http://pubs.acs.org/doi/pdf/10.1021/acsmacrolett.7b00466
  32. Zhou J, Wang Y, Menard LD, Panyukov S, Rubinstein M, Ramsey JM. Enhanced nanochannel translocation and localization of genomic DNA molecules using three-dimensional nanofunnels. Nat Commun. 2017 Oct 9;8(1):807. doi: 10.1038/s41467-017-00951-4. PMID: 28993619; PMCID: PMC5634460. https://www.nature.com/articles/s41467-017-00951-4
  33. Simon JR, Carroll NJ, Rubinstein M, Chilkoti A, López GP. Programming molecular self-assembly of intrinsically disordered proteins containing sequences of low complexity. Nat Chem. 2017 Jun;9(6):509-515. doi: 10.1038/nchem.2715. PMID: 28537592; PMCID: PMC5597244. http://www.nature.com/nchem/journal/vaop/ncurrent/full/nchem.2715.html DOI:10.1038/nchem.2715
  34. Gonzalez MA, Simon JR, Ghoorchian A, Scholl Z, Lin S, Rubinstein M, Marszalek P, Chilkoti A, López GP, Zhao X. Strong, Tough, Stretchable, and Self-Adhesive Hydrogels from Intrinsically Unstructured Proteins. Adv Mater. 2017 Mar;29(10). doi: 10.1002/adma.201604743. PMID: 28060425. http://onlinelibrary.wiley.com/doi/10.1002/adma.201604743/abstract
  35. Ge T, Kalathi JT, Halverson JD, Grest GS, Rubinstein M. Nanoparticle Motion in Entangled Melts of Linear and Nonconcatenated Ring Polymers. Macromolecules. 2017 Feb 28;50(4):1749-1754. doi: 10.1021/acs.macromol.6b02632. PMID: 28392603; PMCID: PMC5379250. http://pubs.acs.org/doi/abs/10.1021/acs.macromol.6b02632
  36. Everaers R, Grosberg AY, Rubinstein M, Rosa A. Flory theory of randomly branched polymers. Soft Matter. 2017 Feb 8;13(6):1223-1234. doi: 10.1039/c6sm02756c. PMID: 28098322; PMCID: PMC5325128. http://pubs.rsc.org/en/content/articlelanding/2017/sm/c6sm02756c#!divAbstract
  37. Paturej J, Sheiko SS, Panyukov S, Rubinstein M. Molecular structure of bottlebrush polymers in melts. Sci Adv. 2016 Nov 11;2(11):e1601478. doi: 10.1126/sciadv.1601478. PMID: 28861466; PMCID: PMC5568649. http://advances.sciencemag.org/content/2/11/e1601478.full
  38. Choueiri RM, Galati E, Thérien-Aubin H, Klinkova A, Larin EM, Querejeta-Fernández A, Han L, Xin HL, Gang O, Zhulina EB, Rubinstein M, Kumacheva E. Surface patterning of nanoparticles with polymer patches. Nature. 2016 Oct 6;538(7623):79-83. doi: 10.1038/nature19089. PMID: 27556943; PMCID: PMC5161688. http://www.nature.com/nature/journal/v538/n7623/full/nature19089.html DOI: 1038/nature19089.
  39. Pandiyarajan CK, Rubinstein M, Genzer J. Surface-Anchored Poly(N-isopropylacrylamide) Orthogonal Gradient Networks. Macromolecules. 2016 Jul 26;49(14):5076-5083. doi: 10.1021/acs.macromol.6b01048. PMID: 27660374; PMCID: PMC5027608. http://pubs.acs.org/doi/full/10.1021/acs.macromol.6b01048
  40. Lebedeva NV, Sanders SN, Ina M, Zhushma AP, Olson SD, Rubinstein M, Sheiko SS. Multicore Expandable Microbubbles: Controlling Density and Expansion Temperature. Polymer. 2016 May 4;90:45-52. doi: 10.1016/j.polymer.2016.02.050. https://www.sciencedirect.com/science/article/pii/S0032386116301306
  41. Baeza GP, Dessi C, Costanzo S, Zhao D, Gong S, Alegria A, Colby RH, Rubinstein M, Vlassopoulos D, Kumar SK. Network dynamics in nanofilled polymers. Nat Commun. 2016 Apr 25;7:11368. doi: 10.1038/ncomms11368. PMID: 27109062; PMCID: PMC4848491. https://www.nature.com/articles/ncomms11368
  42. Leuty GM, Tsige M, Grest GS, Rubinstein M. Tension Amplification in Tethered Layers of Bottle-Brush Polymers. Macromolecules. 2016 Mar 8;49(5):1950-1960. doi: 10.1021/acs.macromol.5b02305. PMID: 27695137; PMCID: PMC5040463. http://pubs.acs.org/doi/abs/10.1021/acs.macromol.5b02305
  43. Daniel WF, Burdyńska J, Vatankhah-Varnoosfaderani M, Matyjaszewski K, Paturej J, Rubinstein M, Dobrynin AV, Sheiko SS. Solvent-free, supersoft and superelastic bottlebrush melts and networks. Nat Mater. 2016 Feb;15(2):183-9. doi: 10.1038/nmat4508. PMID: 26618886. http://www.nature.com/nmat/journal/v15/n2/full/nmat4508.html
  44. Ge T, Panyukov S, Rubinstein M. Self-Similar Conformations and Dynamics in Entangled Melts and Solutions of Nonconcatenated Ring Polymers. Macromolecules. 2016;49(2):708-722. doi: 10.1021/acs.macromol.5b02319. PMID: 27057066; PMCID: PMC4819263. http://pubs.acs.org/doi/abs/10.1021/acs.macromol.5b02319
  45. Li Y, Sarıyer OS, Ramachandran A, Panyukov S, Rubinstein M, Kumacheva E. Universal behavior of hydrogels confined to narrow capillaries. Sci Rep. 2015 Nov 24;5:17017. doi: 10.1038/srep17017. PMID: 26596468; PMCID: PMC4657056. https://www.nature.com/articles/srep17017
  46. Bharti B, Fameau AL, Rubinstein M, Velev OD. Nanocapillarity-mediated magnetic assembly of nanoparticles into ultraflexible filaments and reconfigurable networks. Nat Mater. 2015 Nov;14(11):1104-9. doi: 10.1038/nmat4364. PMID: 26237128; PMCID: PMC4816044. https://www.nature.com/articles/nmat4364
  47. Cai LH, Kodger TE, Guerra RE, Pegoraro AF, Rubinstein M, Weitz DA. Soft Poly(dimethylsiloxane) Elastomers from Architecture-Driven Entanglement Free Design. Adv Mater. 2015 Sep 16;27(35):5132-40. doi: 10.1002/adma.201502771. PMID: 26259975; PMCID: PMC4662383. https://onlinelibrary.wiley.com/doi/10.1002/adma.201502771
  48. Anderson WH, Coakley RD, Button B, Henderson AG, Zeman KL, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Bailey S, Fuller F, Almond M, Qaqish B, Bordonali E, Rubinstein M, Bennett WD, Kesimer M, Boucher RC. The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis. Am J Respir Crit Care Med. 2015 Jul 15;192(2):182-90. doi: 10.1164/rccm.201412-2230OC. PMID: 25909230; PMCID: PMC4532825. https://www.atsjournals.org/doi/10.1164/rccm.201412-2230OC
  49. Hassouneh W, Zhulina EB, Chilkoti A, Rubinstein M. Elastin-like Polypeptide Diblock Copolymers Self-Assemble into Weak Micelles. Macromolecules. 2015 Jun 23;48(12):4183-4195. doi: 10.1021/acs.macromol.5b00431. PMID: 27065492; PMCID: PMC4822422. https://pubs.acs.org/doi/abs/10.1021/acs.macromol.5b00431
  50. Ge T, Rubinstein M. Strong Selective Adsorption of Polymers. Macromolecules. 2015 Jun 9;48(11):3788-3801. doi: 10.1021/acs.macromol.5b00586. PMID: 27065491; PMCID: PMC4819262. https://pubs.acs.org/doi/abs/10.1021/acs.macromol.5b00586
  51. Kalathi JT, Kumar SK, Rubinstein M, Grest GS. Rouse mode analysis of chain relaxation in polymer nanocomposites. Soft Matter. 2015 May 28;11(20):4123-32. doi: 10.1039/c5sm00754b. PMID: 25939276; PMCID: PMC4840937. https://pubs.rsc.org/en/content/articlelanding/2015/SM/C5SM00754B
  52. Hegde M, Samulski ET, Rubinstein M, Dingemans TJ. The Role of Crystallinity in SWCNT–Polyetherimide Nanocomposites. Compos Sci Technol. 2015 Apr 6;110:176-187. doi: 10.1016/j.compscitech.2015.02.004. https://www.sciencedirect.com/science/article/abs/pii/S0266353815000755
  53. Liu AJ, Grest GS, Marchetti MC, Grason GM, Robbins MO, Fredrickson GH, Rubinstein M, Olvera de la Cruz M. Opportunities in theoretical and computational polymeric materials and soft matter. Soft Matter. 2015 Mar 28;11(12):2326-32. doi: 10.1039/c4sm02344g. PMID: 25711605. https://pubs.rsc.org/en/content/articlelanding/2015/SM/C4SM02344G
  54. Gooßen S, Brás AR, Pyckhout-Hintzen W, Wischnewski A, Richter D, Rubinstein M, Roovers J, Lutz PJ, Jeong Y, Chang T, Vlassopoulos D. Influence of the Solvent Quality on Ring Polymer Dimensions. Macromolecules. 2015 Mar 10;48(5):1598-1605. doi: 10.1021/ma502518p. PMID: 27065493; PMCID: PMC4822511. https://pubs.acs.org/doi/abs/10.1021/ma502518p
  55. Lang M, Rubinstein M, Sommer JU. Conformations of a Long Polymer in a Melt of Shorter Chains: Generalizations of the Flory Theorem. ACS Macro Lett. 2015 Feb 17;4(2):177-181. doi: 10.1021/mz500777r. PMID: 26543675; PMCID: PMC4621164. https://pubs.acs.org/doi/abs/10.1021/mz500777r
  56. Cai LH, Panyukov S, Rubinstein M. Hopping Diffusion of Nanoparticles in Polymer Matrices. Macromolecules. 2015 Feb 10;48(3):847-862. doi: 10.1021/ma501608x. PMID: 25691803; PMCID: PMC4325603. https://pubs.acs.org/doi/abs/10.1021/ma501608x
Michael Rubinstein