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Associate Professor

Selected Bibliography:

  1. Tasoudis P, Lobo LJ, Coakley RD, Agala CB, Egan TM, Haithcock BE, Mody GN, Long JM. Outcomes Following Lung Transplant for COVID-19-Related Complications in the US. JAMA Surg. 2023 Nov 1;158(11):1159. doi: 10.1001/jamasurg.2023.3489. PMID: 37585215; PMCID: PMC10433141.
  2. Ghosh A, Coakley RD, Alexis NE, Tarran R. Vaping-Induced Proteolysis Causes Airway Surface Dehydration. Int J Mol Sci. 2023 Oct 19;24(20):15348. doi: 10.3390/ijms242015348. PMID: 37895029; PMCID: PMC10607227.
  3. McKinzie CJ, Doligalski CT, Lobritto SJ, Coakley RD, Gower WA. Use of elexacaftor/tezacaftor/ivacaftor in liver transplant patients with cystic fibrosis. J Cyst Fibros. 2022 Mar;21(2):227-229. doi: 10.1016/j.jcf.2021.07.017. PMID: 34384711.
  4. Davis ES, Ghosh A, Coakley RD, Wrennall JA, Lubamba BA, Rowell TR, Dang H, Pawlak EA, Li Q, Alexis NE, Ribeiro CMP, Tarran R. Chronic E-Cigarette Exposure Alters Human Alveolar Macrophage Morphology and Gene Expression. Nicotine Tob Res. 2022 Feb 14;24(3):395-399. doi: 10.1093/ntr/ntab186. PMID: 34519792. PMCID: PMC8842413.
  5. Ghosh A, Girish V, Yuan ML, Coakley RD, Wrennall JA, Alexis NE, Sausville EL, Vasudevan A, Chait AR, Sheltzer JM, Tarran R. Combustible and Electronic Cigarette Exposures Increase ACE2 Activity and SARS-CoV-2 Spike Binding. Am J Respir Crit Care Med. 2022 Jan 1;205(1):129-133. doi: 10.1164/rccm.202106-1377LE. PMID: 34748720. PMCID: PMC8865588.
  6. Ghosh A, Ahmad S, Coakley RD, Sassano MF, Alexis NE, Tarran R. Lipid Laden Macrophages are not Unique to EVALI Patients. Am J Respir Crit Care Med. 2021 Apr 15;203(8):1030-1033. doi: 10.1164/rccm.202009-3507LE. PMID: 33332247. PMCID: PMC8048758.
  7. Ghosh A, Coakley RD, Ghio AJ, Muhlebach MS, Esther CR Jr, Alexis NE, Tarran R. Chronic E-Cigarette Use Increases Neutrophil Elastase and Matrix Metalloprotease Levels in the Lung. Am J Respir Crit Care Med. 2019 Dec 1;200(11):1392-1401. doi: 10.1164/rccm.201903-0615OC. PMID: 31390877. PMCID: PMC6884043.
  8. Henderson AG, Anderson WH, Ceppe A, Coakley RD, Button B, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Fuller F, Almond M, Qaqish B, Kesimer M, Boucher RC. Mucus hydration in subjects with stable chronic bronchitis: A comparison of spontaneous and induced sputum. COPD. 2018 Dec;15(6):572-580. doi: 10.1080/15412555.2019.1566892. PMID: 30712400. PMCID: PMC6428611.
  9. Ghosh A, Coakley RD, Mascenik T, Rowell TR, Davis ES, Rogers K, Webster MJ, Dang H, Herring LE, Sassano MF, Livraghi-Butrico A, Van Buren SK, Graves LM, Herman MA, Randell SH, Alexis NE, Tarran R. Chronic e-cigarette exposure alters the human bronchial epithelial proteome. Am J Respir Crit Care Med. 2018 Jul 1;198(1):67-76. doi: 10.1164/rccm.201710-2033OC. PMID: 29481290. PMCID: PMC6034122.
  10. Abdullah LH, Coakley R, Webster MJ, Zhu Y, Tarran R, Radicioni G, Kesimer M, Boucher RC, Davis CW, Ribeiro CMP. Mucin production and hydration responses to mucopurulent materials in normal vs. CF airway epithelia. Am J Respir Crit Care Med. 2018 Feb 15;197(4):481-491. doi: 10.1164/rccm.201706-1139OC. PMID: 29099608. PMCID: PMC5821906.
  11. Abdullah LH, Evans JR, Wang TT, Ford AA, Makhov AM, Nguyen K, Coakley RD, Griffith JD, Davis CW, Ballard ST, Kesimer M. Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways. JCI Insight. 2017 Mar 23;2(6):e89752. doi: 10.1172/jci.insight.89752. PMID: 28352653. PMCID: PMC5358479.
  12. Esther CR Jr, Coakley RD, Henderson AG, Zhou YH, Wright FA, Boucher RC. Metabolomic evaluation of neutrophilic airway inflammation in cystic fibrosis. Chest. 2015 Aug;148(2):507-15. doi: 10.1378/chest.14-1800. PMID: 25611918; PMCID: PMC4524329.
  13. Anderson WH, Coakley RD, Button B, Henderson AG, Zeman KL, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Bailey S, Fuller F, Almond M, Qaqish B, Bordonali E, Rubinstein M, Bennett WD, Kesimer M, Boucher RC. The relationship of mucus concentration (hydration) to mucus osmotic pressure and transport in chronic bronchitis. Am J Respir Crit Care Med. 2015 Jul 15;192(2):182-90. doi: 10.1164/rccm.201412-2230OC. PMID: 25909230;  PMCID: PMC4532825.
  14. Garland AL, Walton WG, Coakley RD, Tan CD, Gilmore RC, Hobbs CA, Tripathy A, Clunes LA, Bencharit S, Stutts MJ, Betts L, Redinbo MR, Tarran R. Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):15973-8. doi: 10.1073/pnas.1311999110. PMID: 24043776; PMCID: PMC3791714.
  15. Clunes LA, Davies CM, Coakley RD, Aleksandrov AA, Henderson AG, Zeman KL, Worthington EN, Gentzsch M, Kreda SM, Cholon D, Bennett WD, Riordan JR, Boucher RC, Tarran R. Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration. FASEB J. 2012 Feb;26(2):533-45. doi: 10.1096/fj.11-192377. PMID: 21990373; PMCID: PMC3290447.
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  • Phone Number

    (Office Phone)

  • Address

    4135 Bioinformatics Bldg

    Pulmonary & Critical Care Medicine

    Campus Box 7020

    Chapel Hill, NC 27599-7020