The University of North Carolina at Chapel Hill
Skip to main content
UNC School of Medicine

Marsico Lung Institute Publications for April 2026

By

Marsico Lung Institute faculty, postdoc, student, and collaborator publications for April 2026 (and a couple stragglers from March) included papers appearing in Trends in Genetics, Journal of Allergy & Clinical Immunology, and Journal of Clinical Investigation. Check out the full list below:

  1. Smyth TR, Brocke S, Wu W, An Z, Jaspers I. RNAseq analysis demonstrates polarization state-dependent responses to ambient particulate matter in a particle composition-specific manner. Toxicol Sci. 2026 Apr 30:kfag050. doi: 10.1093/toxsci/kfag050. Epub ahead of print. PMID: 42063226.
  2. Freeman AF, Wang C, Urban A, Martin I, Dang L, Davis J, Bergerson JRE, Ali S, An ZA, Patel M, Williamson H, Marciano BE, Lafeer C, Roy S, Ulrick J, Heller T, Sharma D, Castelo-Soccio L, Cowen EW, Kong HH, Gupta S, Ghosh R, Seifert BA, Tokita MJ, Walkiewicz MA, Similuk M, Stoddard J, Rosenzweig SD, Matta JR, Gharib AM, Jahanmir G, Brenchley L, Shastri K, Moutsopoulos NM, Kitani T, Arnold DE, Dimitrova D, Gonzalez CE, Pai SY, Malech HL, Gallin JI, Fennelly K, Olivier KN, Mackie J, Tangye SG, Hsu AP, Milner JD, Heimall J, Holland SM. Clinical features, genetics, treatment, and long-term outcomes of STAT3 hyper-IgE syndrome: a single-center cohort analysis. J Allergy Clin Immunol. 2026 Apr 28:S0091-6749(26)00292-7. doi: 10.1016/j.jaci.2026.04.012. Epub ahead of print. PMID: 42061468.
  3. Gentzsch M, Boyles SE, Minges JT, Cholon DM, Okuda K, Ribeiro CMP. The cystic fibrosis airway cytokine interleukin-1β enhances cystic fibrosis transmembrane conductance regulator modulator efficacy. ERJ Open Res. 2026 Apr 27;12(2):01492-2025. doi: 10.1183/23120541.01492-2025. PMID: 42111373; PMCID: PMC13152372.
  4. Mofidi SM, Sahoo A, Edelmaier CJ, Klawa SJ, Freeman R, Gladfelter A, Forest MG, Nazockdast E, Hanson SM. Study of Protein-Protein Interactions in Septin Assembly: Multiple amphipathic helix domains cooperate in binding to the lipid membrane. PLoS Comput Biol. 2026 Apr 27;22(4):e1014230. doi: 10.1371/journal.pcbi.1014230. PMID: 42044171; PMCID: PMC13143081.
  5. Tan SZK, Puig-Barbe A, Goutte-Gattat D, Eastwood C, Aevermann B, Avola A, Balhoff JP, Bayindir IU, Belfiore J, Caron AR, Fischer DS, George N, Gyori BM, Haendel MA, Hoyt CT, Kir H, Lubiana T, Matentzoglu N, Overton JA, Peng B, Peters B, Quardokus EM, Ray PL, Roncaglia P, Rivera AD, Stefancsik R, Teh WK, Toro S, Vasilevsky N, Xu C, Zhang Y, Scheuermann RH, Mungall CJ, Diehl AD, Osumi-Sutherland D. The Cell Ontology in the age of single-cell omics. Sci Data. 2026 Apr 24. doi: 10.1038/s41597-026-07173-8. Epub ahead of print. PMID: 42031777.
  6. Abelman RA, Xia F, Drummond MB, Kempf MC, Alcaide ML, Collins LF, Spence AB, Peters BA, Gustafson D, Kunisaki KM, Wang RJ, Tien PC, Huang L. Menopause is associated with lower lung function in women with and without HIV. Chest. 2026 Apr 23:S0012-3692(26)00556-8. doi: 10.1016/j.chest.2026.02.050. Epub ahead of print. PMID: 42034331; PMCID: PMC13160286.
  7. He M, Xu B, Bose PG, McCullough MJ, Sellers RS, Zong X, Qi W, Banten BL, Tune MK, Zimmerman MP, Mullins GN, Miller BC, Milner JJ, Whitmire JK, Tsagaratou A, Shpargel KB, Doerschuk CM, Wang YD, Steele JA, Pruett-Miller SM, Feng Y, Mock JR. T cell receptor signaling induces expression of lysine demethylase KDM6B to maintainTreg homeostasis. J Clin Invest. 2026 Apr 23:e196022. doi: 10.1172/JCI196022. Epub ahead of print. PMID: 42024441.
  8. Chappel JR, Kim YH, Gilmour MI, Baker ES, Jaspers I, Weigand TM, Rager JE. Interpretable Machine Learning to Understand Wildfire Toxicity: Bridging Chemicals, Omics, and Toxicological Outcomes via Symbolic Regression with Novel Feature Scoring. Chem Res Toxicol. 2026 Apr 20;39(4):530-543. doi: 10.1021/acs.chemrestox.5c00440. PMID: 41928614. PMCID: PMC13100985.
  9. Liu Q, Lyu LD. Heterogeneity in microbial antibiotic responses: genetic basis and within-host evolution. Trends Genet. 2026 Apr 17:S0168-9525(26)00085-5. doi: 10.1016/j.tig.2026.03.008. Epub ahead of print. PMID: 42000255; PMCID: PMC13094712.
  10. Hersh CP, Teckman JH, Strnad P, Hakim A, Carroll TP, Hall IP, Ghosh AJ, Barjaktarevic I, McElvaney NG, Kaserman JE, Lomas DA, Strange C, Drummond MB, Rennard S, Hanna KE, Clark VC, Goldklang MP, Iverson P, Wilson AA. Z variant heterozygosity in alpha-1 antitrypsin deficiency: disease risk and treatment implications. Orphanet J Rare Dis. 2026 Apr 8;21(1):136. doi: 10.1186/s13023-026-04283-9. PMID: 41952152; PMCID: PMC13063764.
  11. Markovetz MR, Wei S, Celluci C, Roberts M, Han L. Cervical mucus viscoelasticity and sperm velocity are correlated and concentration-dependent in Vitro. PLoS One. 2026 Apr 7;21(4):e0325574. doi: 10.1371/journal.pone.0325574. PMID: 41945590; PMCID: PMC13056177.
  12. Esther CR Jr, Fallon JK, Cholon DM, Boyles SE, Williams AB, Murano H, Okuda K, Tiley JB, Tan ML, Zhao L, Mikami Y, Smith PC, Rao G, Gentzsch M. Influence of inflammation on drug transporter expression in human airway epithelia: Implications for inhaled drug pharmacokinetics. Drug Metab Dispos. 2026 Apr 1;54(5):100287. doi: 10.1016/j.dmd.2026.100287. Epub ahead of print. PMID: 42066732.
  13. Gardner RA, Ferkol TW, Shapiro AJ. Treatment of Lung Disease in Primary Ciliary Dyskinesia: A Review of Current and Emerging Interventions. Pediatr Pulmonol. 2026 Apr;61(4):e71575. doi: 10.1002/ppul.71575. PMID: 41889168.
  14. Pennington ER, Pulczinski JC, Case MW, Griffin JS, Alexis NE, Jaspers I, Robinette C, Chelminski A, Davis A, Miller N, Peden DB, Ghio AJ, Diaz-Sanchez D, Rappold AG. Lung function and inflammation in healthy young adults after 6.6 hours of 0.07 ppm ozone exposure. Environ Res. 2026 Apr 1;300:124387. doi: 10.1016/j.envres.2026.124387. Epub ahead of print. PMID: 41933867.
  15. Randell SH, Barnett KC. Co-Culture Systems to Study Epithelial-Immune Interactions During SARS-CoV-2 Infection. Curr Protoc. 2026 Apr;6(4):e70365. doi: 10.1002/cpz1.70365. PMID: 41949496; PMCID: PMC13060367.
  16. Schichlein KD, Jaspers I, Drummond MB. Reconsidering Vitamin D Supplementation in Pulmonary Disease: The Case for Targeted Respiratory Delivery. Chronic Obstr Pulm Dis. 2026 Mar 31. doi: 10.15326/jcopdf.2025.0713. Epub ahead of print. PMID: 41950523.
  17. Oh E, Miller JE, Lee MJ, Zemke A, Baraghoshi D, Strand MJ, Alt JA, Bodner TE, Chang M, Chowdhury NI, Eshaghian PH, Getz AE, Goralski JL, Gudis DA, Hwang PH, Khanwalkar A, Kimple AJ, Lee JT, Li DA, Mace JC, Nayak JV, Overdevest JB, Patel Z, Safatian DK, Schlosser RJ, Senior B, Stapleton AL, Smith TL, Soler ZM, Suh JD, Turner GA, Wang MB, Saavedra MT, Taylor-Cousar JL, Beswick DM. Determining the Minimal Clinically Important Difference of the 40-Item Smell Identification Test in People With Cystic Fibrosis. Int Forum Allergy Rhinol. 2026 Mar 13. doi: 10.1002/alr.70136. Epub ahead of print. PMID: 41830161.

Filed Under:

Categories: News