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Marsico Lung Institute Publications for April-June 2025

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Marsico Lung Institute faculty, postdoc, student, and collaborator publications for April through June 2025 (plus a couple strays from March) included papers appearing in Nature Communications, The American Journal of Respiratory & Critical Care Medicine, and Clinical Infectious Diseases. Check out the full list below:

  1. Stasko N, Arwood L, Jandick N, Spragion D, Roberts RC, Setién M, Henson I, Annas A, Fulcher ML, Brotton M, Kummer L, Szaba F, Reagan M, Lanzer K, Cookenham T, Casey S, Kothapalli N, Hart T, Bradrick SS, Emerson D, Cockrell AS, Randell SH, Kocher JF. The pan-variant potential of light: 425 nm light inactivates SARS-CoV-2 variants of concern and non-cytotoxic doses reduce viral titers in human airway epithelial cells. mSphere. 2025 Jun 25;10(6):e0023025. doi: 10.1128/msphere.00230-25. PMID: 40434113; PMCID: PMC12188739.
  2. Evans A, VanWyk J, Kerr M, Couper A, Pace WD, Tarabichi Y, Pullen R, Pollack M, Drummond MB, Ohar J, Meldrum C, Han MK, Kaplan A, Winders T, Wisnivesky J, Make B, Federman A, Carter V, Lang K, Mapel D, Hanania NA, Stolz D, Martinez FJ, Price D. Practical strategies for achieving system change in the US: lessons and insights from the CONQUEST quality improvement programme. Prim Health Care Res Dev. 2025 Jun 23;26:e50. doi: 10.1017/S1463423625100170. PMID: 40546134; PMCID: PMC12188133.
  3. Lu X, Jiang Y, Zhang R, Zhang Y, Li J, Wang L, Ye Q, Hou R, Lu Y, Zhu X, Ji Y, Gan M, Li M, Liu Q, Shen X, Yang C. Epidemiologic and Bacterial Factors Facilitating Long-Term Transmission of Multidrug-Resistant Tuberculosis in Shanghai, China. Clin Infect Dis. 2025 Jun 18:ciaf313. doi: 10.1093/cid/ciaf313. Epub ahead of print. PMID: 40576551.
  4. Ryerson CJ, Jennerich AL, Nici L, Raghu G, Ghazipura M, Aaron SD, Cristea AI, Dela Cruz C, Drummond MB, Ehsan Z, Evans SE, Feller-Kopman D, Hayes D Jr, Iyer NP, Jenkins AR, Holland AE, Jacobs SS, Krishnan JA, Macrea M, Oren E, Owens RL, Rochwerg B, Strange C, Wilson KC. Clinical Practice Guidelines: Quality, Breadth, and Currency. Ann Am Thorac Soc. 2025 Jun 16. doi: 10.1513/AnnalsATS.202501-097PS. Epub ahead of print. PMID: 40523263.
  5. Niyonkuru E, Caufield JH, Carmody LC, Gargano MA, Toro S, Whetzel PL, Blau H, Soto Gomez M, Casiraghi E, Chimirri L, Reese JT, Valentini G, Haendel MA, Mungall CJ, Robinson PN. Leveraging generative AI to assist biocuration of medical actions for rare disease. Bioinform Adv. 2025 Jun 12;5(1):vbaf141. doi: 10.1093/bioadv/vbaf141. PMID: 40621601; PMCID: PMC12228962.
  6. Higgs MG, Greenwald MA, Roca C, Macdonald JK, Sidders AE, Conlon BP, Wolfgang MC. Flagellar motility and the mucus environment influence aggregation-mediated antibiotic tolerance of Pseudomonas aeruginosa in chronic lung infection. mBio. 2025 Jun 11;16(6):e0083125. doi: 10.1128/mbio.00831-25. PMID: 40372059; PMCID: PMC12153314.
  7. Wolber AR, McKay LS, Mote KB, Johnson RM, Inatsuka CS, Cotter PA. Nuanced differences in adenylate cyclase toxin production, acylation, and secretion may contribute to the evolution of virulence in Bordetella species. mBio. 2025 Jun 11;16(6):e0108225. doi: 10.1128/mbio.01082-25. PMID: 40387377; PMCID: PMC12153271.
  8. Easter QT, Alvarado-Martinez Z, Kunz M, Matuck BF, Rupp BT, Weaver T, Ren Z, Tata A, Caballero-Perez J, Oscarson N, Hasuike A, Ghodke AN, Kimple AJ, Tata PR, Randell SH, Koo H, Ko KI, Byrd KM. Polybacterial intracellular macromolecules shape single-cell inflammatory profiles in upper airway epithelia. NPJ Biofilms Microbiomes. 2025 Jun 10;11(1):100. doi: 10.1038/s41522-025-00735-5. PMID: 40494852; PMCID: PMC12152179.
  9. Smith GJ, Immormino RM, Ferris MT, Lester SA, Moran TP, Harkema JR, Kelada SNP. A new mouse model for ozone health effects research. Environ Health Perspect. 2025 Jun 5. doi: 10.1289/EHP15745. Epub ahead of print. PMID: 40471753.
  10. Yuan J, Lin L, Weinfurt K, Lucas N, Burbank AJ, Hernandez ML, Huang IC, Reeve BB. Meaningful Score Differences and Meaningful Score Regions of the Patient-Reported Outcomes Measurement Information System® Pediatric Asthma Impact Scale. Value Health. 2025 Jun 5:S1098-3015(25)02371-X. doi: 10.1016/j.jval.2025.05.010. Epub ahead of print. PMID: 40482769.
  11. Drummond MB, Hemphill CC, Hill T, Boe A, Yu D, Ohar JA. Use of a Digital Inhaler to Assess COPD Disease Variability and Identify Impending Acute COPD Exacerbations: A Pilot Study. Chronic Obstr Pulm Dis. 2025 May 27;12(3):250-259. doi: 10.15326/jcopdf.2024.0555. PMID: 40459430; PMCID: PMC12212364.
  12. Hickman K, Tarabichi Y, Dickens AP, Pullen R, Kerr M, Couper A, Evans A, Gatenby J, Alves L, Ariti C, Bafadhel M, Carter V, Chalmers J, Chen R, Devereux G, Drummond MB, Gibson JM, Halpin DMG, Han M, Hanania NA, Hurst JR, Kaplan A, Kostikas K, Make B, Mapel D, Marshall J, Martinez F, Meldrum C, van Melle M, Miravitlles M, Morris T, Mullerova H, Murray R, Muro S, Nordon C, Ohar J, Pace W, Pollack M, Quint JK, Sharma A, Singh D, Singh M, Trudo F, Williams D, Wilkinson T, Winders T, Price D. Pragmatic Evaluation of an Improvement Program for People Living With Modifiable High-Risk COPD Versus Usual Care: Protocols for the Cluster Randomized PREVAIL Trial. Chronic Obstr Pulm Dis. 2025 May 27;12(3):223-239. doi: 10.15326/jcopdf.2024.0564. PMID: 40300198; PMCID: PMC12212362.
  13. Vo T, Patial S, Saini Y. Repetitive ozone exposure worsens features of muco-inflammatory disease in developed Scnn1b-Tg+ mice lungs. Front Toxicol. 2025 May 27;7:1540468. doi: 10.3389/ftox.2025.1540468. PMID: 40496925; PMCID: PMC12148915.
  14. Lowrey LC, Mote KB, Cotter PA. DNA duplication in Burkholderia thailandensis induces biofilm formation by activating a two-component regulatory system. PLoS Genet. 2025 May 20;21(5):e1011528. doi: 10.1371/journal.pgen.1011528. PMID: 40392945; PMCID: PMC12124856.
  15. Roca C, Mirmozaffari Y, Martin WJ, Capps N, Sullivan KM, Thorp BD, Ferkol TW, Davis SD, Kimple A, Wolfgang MC. Advances in Sinonasal Microbiome Analysis. Ear Nose Throat J. 2025 May 19:1455613251341711. doi: 10.1177/01455613251341711. Epub ahead of print. PMID: 40384122.
  16. Cobos-Uribe C, Dhingra R, Almond MA, Alexis NE, Peden DB, Roach J, Rebuli ME. Human Sputum Microbiome Composition and Sputum Inflammatory Cell Profiles Are Altered with Controlled Wood Smoke Exposure as a Model for Wildfire Smoke. Am J Respir Crit Care Med. 2025 May 16. doi: 10.1164/rccm.202407-1493OC. Epub ahead of print. PMID: 40377699.
  17. Chen H, Fischer JL, Tibbe TD, Sedaghat AR, Han EJ, Mace JC, Alt JA, Bodner TE, Chowdhury NI, Gao YA, Hwang PH, Khanwalkar A, Kimple AJ, Lee JT, Li DA, Norris M, Nayak JV, Collins C, Patel ZM, Phillips K, Poch K, Schlosser RJ, Smith KA, Soler ZM, Suh JD, Turner GA, Wang MB, Getz A, Halderman A, Chung S, Tervo JP, Overdevest JB, Cotter RA, Saavedra MT, Taylor-Cousar JL, Sim MS, Beswick DM. Abridging the 22-Item Sino-Nasal Outcome Test (SNOT-22) in People With Cystic Fibrosis: Limiting Survey Burden. Int Forum Allergy Rhinol. 2025 May 15:e23591. doi: 10.1002/alr.23591. Epub ahead of print. PMID: 40371719.
  18. Solomon BD, Cheatham M, de Guimarães TAC, Duong D, Haendel MA, Hsieh TC, Javanmardi B, Johnson B, Krawitz P, Kruszka P, Laurent T, Lee NC, McWalter K, Michaelides M, Mohnike K, Pontikos N, Guillen Sacoto MJ, Shwetar YJ, Ustach VD, Waikel RL, Woof W. Perspectives on the Current and Future State of Artificial Intelligence in Medical Genetics. Am J Med Genet A. 2025 May 15:e64118. doi: 10.1002/ajmg.a.64118. Epub ahead of print. PMID: 40375359.
  19. Choudhary I, Paudel K, Kumar R, Sharma A, Patial S, Saini Y. Airway epithelial cell-specific deletion of EGFR modulates mucoinflammatory features of cystic fibrosis-like lung disease in mice. Front Immunol. 2025 May 8;16:1493950. doi: 10.3389/fimmu.2025.1493950. PMID: 40406132; PMCID: PMC12094982.
  20. Kajiwara C, Shiozawa A, Arai S, Yamaguchi T, Harada S, Miyazaki T, Tateda K. Apoptosis inhibitor of macrophage suppress immune responses via IL-10 production and delay bacterial clearance in Mycobacterium avium infection. Front Cell Infect Microbiol. 2025 May 5;15:1578082. doi: 10.3389/fcimb.2025.1578082. PMID: 40391046; PMCID: PMC12086163.
  21. Sun L, Walls SA, Dang H, Quinney NL, Sears PR, Sadritabrizi T, Hasegawa K, Okuda K, Asakura T, Chang X, Zheng M, Mikami Y, Dizmond FU, Danilova D, Zhou L, Deshmukh A, Cholon DM, Radicioni G, Rogers TD, Kissner WJ, Markovetz MR, Guhr Lee TN, Gutay MI, Esther CR Jr, Chua M, Grubb BR, Ehre C, Kesimer M, Hill DB, Ostrowski LE, Button B, Gentzsch M, Robinson C, Olivier KN, Freeman AF, Randell SH, Vladar E, O’Neal WK, Boucher RC Jr, Chen G. STAT3-dependent Regulation of CFTR and Ciliogenesis Is Essential for Mucociliary Clearance and Innate Airway Defense in Hyper-IgE Syndrome. Am J Respir Crit Care Med. 2025 May 2. doi: 10.1164/rccm.202407-1415OC. Epub ahead of print. PMID: 40315437.
  22. Barber AT, Davis SD, Ferkol TW, Shapiro AJ, Atkinson J, Sagel SD, Dell SD, Olivier K, Milla C, Rosenfeld M, Li L, Lin FC, Sullivan KM, Capps NA, Zariwala MA, Knowles MR, Leigh MW; Genetic Disorders of Mucociliary Clearance Consortium (GDMCC). The Association of Neonatal Respiratory Distress With Ciliary Ultrastructure and Genotype in Primary Ciliary Dyskinesia. Pediatr Pulmonol. 2025 May;60(5):e71091. doi: 10.1002/ppul.71091. PMID: 40344341; PMCID: PMC12063519.
  23. Cogen JD, Zhang E, She J, Kosorok MR, Cheng SY, Muhlebach MS. Association between inhaled antibiotic use and treatment-emergent organisms among Canadian people with cystic fibrosis. J Cyst Fibros. 2025 May 1:S1569-1993(25)01462-6. doi: 10.1016/j.jcf.2025.04.007. Epub ahead of print. PMID: 40312233.
  24. Expert Panel on Thoracic Imaging; Christensen JD, Harowicz M, Walker CM, Little BP, Batra K, Brixey AG, Carroll MB, Chelala L, Cox CW, Drummond MB, Geissen NM, Halpern J, Madan R, Gopalakrishnan VP, Shroff GS, Thornton CS, Zreloff J, Chung JH. ACR Appropriateness Criteria® Chronic Dyspnea-Noncardiovascular Origin: 2024 Update. J Am Coll Radiol. 2025 May;22(5S):S163-S176. doi: 10.1016/j.jacr.2025.02.034. PMID: 40409875.
  25. Kharitonova EV, Sun Q, Ockerman F, Chen B, Zhou LY, Hysong MR, Tuftin B, Cao H, Mathias RA, Auer PL, Ober C, Raffield LM, Reiner AP, Cox NJ, Kelada SNP, Tao R, Li Y. EndoPRS: Incorporating endophenotype information to improve polygenic risk scores for clinical endpoints-A study in asthma. Am J Hum Genet. 2025 May 1;112(5):1199-1214. doi: 10.1016/j.ajhg.2025.03.008. PMID: 40203832; PMCID: PMC12120184.
  26. Sowa NA, Pudukodu H, Ceppe A, Goralski JL. Obsessive-compulsive disorder symptoms in an adult cystic fibrosis population. J Psychosom Res. 2025 May;192:112118. doi: 10.1016/j.jpsychores.2025.112118. PMID: 40179605.
  27. Love CA, Kim HH, Tallman KA, Clapp PW, Schichlein KD, Porter NA, Jaspers I. Vaping-induced Oxidation of CBD Causes Adduction of TOP2A and Interferes with Cellular Proliferation. Am J Respir Cell Mol Biol. 2025 Apr 30. doi: 10.1165/rcmb.2024-0501OC. Epub ahead of print. PMID: 40305674.
  28. Ozkan E, Livengood SS, Ford AA, Macdonald JK, Samir S, Klevans IW, Kesimer M. Analytical validation of total mucin concentration assay using SEC MALLS dRI for diagnosing and monitoring mucoobstructive lung diseases. Sci Rep. 2025 Apr 29;15(1):15024. doi: 10.1038/s41598-025-97808-4. PMID: 40301448; PMCID: PMC12041582.
  29. SantaBarbara NJ, St Hilaire MA, Konkle-Parker DJ, Comulada WS, Cantrell J, D’Souza A, Foronjy R, Koletar SL, Mimiaga MJ, Palella FJ Jr, Merenstein D, Rubtsova AA, Raju S, Martinez CA, Hanna DB, Drummond MB, Weber KM, Wang R, Erlandson KM. Physical Activity, Cigarette Smoking, and Depression Among People with HIV. AIDS Behav. 2025 Apr 29. doi: 10.1007/s10461-025-04727-6. Epub ahead of print. PMID: 40299258.
  30. Lee-Ferris RE, Okuda K, Galiger JR, Schworer SA, Rogers TD, Dang H, Gilmore R, Edwards C, Crisp G, Nakano S, Cawley AM, Pickles RJ, Gallant SC, Crisci E, Rivier L, Hagood JS, O’Neal WK, Baric RS, Grubb BR, Boucher RC, Randell SH. Prolonged airway explant culture enables study of health, disease, and viral pathogenesis. Sci Adv. 2025 Apr 25;11(17):eadp0451. doi: 10.1126/sciadv.adp0451. PMID: 40279421; PMCID: PMC12024639.
  31. Goldklang MP, Pirozzi C, Barjaktarevic I, Bhatt S, Bodduluri S, Drummond MB, Hogarth DK, Keaveny A, Liu Z, McElvaney NG, McElvaney OJ, Nuchovich N, Palumbo S, Plant R, Sandhaus R, Wells JM, Wilson A, Strange C, D’Armiento JM; Alpha-1 Biomarker Consortium Study Group. Rationale and Design of the Alpha-1 Biomarkers Consortium Study. Chronic Obstr Pulm Dis. 2025 Apr 24. doi: 10.15326/jcopdf.2025.0603. Epub ahead of print. PMID: 40273316.
  32. Waltz M, Foreman AKM, Gibson RA, Schilling S, Milko LV, Phillips R, O’Daniel JM, Giric S, Foss K, Branch EK, DeJong NA, Hernandez ML, Powell BC, Berg JS, Cadigan RJ, Roberts MC. Age-Based Genomic Screening: Pediatric Providers’ Perspectives on Implementation. Public Health Genomics. 2025;28(1):180-189. doi: 10.1159/000545839. Epub 2025 Apr 21. PMID: 40258355; PMCID: PMC12133400.
  33. Breger TL, Westreich DJ, Edmonds A, Edwards JK, Cole SR, Ramirez C, Diggs AE, Ofotokun I, Kassaye SG, Brown TT, Konkle-Parker D, Palella FJ, Krier S, Jones DL, D’Souza G, Cohen MH, Tien PC, Taylor TN, Anastos K, Hinderliter AL, Eron JJ, Drummond MB, Floris-Moore MA. Incidence of statin initiation among people with and without HIV in the US: a prospective observational study. Clin Infect Dis. 2025 Apr 17:ciaf207. doi: 10.1093/cid/ciaf207. Epub ahead of print. PMID: 40244915.
  34. McPeek MK, Martin JR, Gomez JC, Li Y, Dang H, Earp HS, Doerschuk CM. Host responses to S. pneumoniae in wild type and Mertk mutant mice. PLoS One. 2025 Apr 16;20(4):e0320660. doi: 10.1371/journal.pone.0320660. PMID: 40238852; PMCID: PMC12002534.
  35. Edelmaier CJ, Klawa SJ, Mofidi SM, Wang Q, Bhonge S, Vogt EJD, Curtis BN, Shi W, Hanson SM, Klotsa D, Forest MG, Gladfelter AS, Freeman R, Nazockdast E. Charge distribution and helicity tune the binding of septin’s amphipathic helix domain to membranes. Biophys J. 2025 Apr 15;124(8):1298-1312. doi: 10.1016/j.bpj.2025.03.008. PMID: 40179880; PMCID: PMC12044399.
  36. Nick JA, Martiniano SL, Lovell VK, Vestal B, Poch K, Caceres SM, Rysavy NM, de Moura VC, Gilick JJ, Malcolm KC, Pacheco J, Amin AG, Chatterjee D, Daley CL, Kasperbauer S, Gross JE, Armantrout E, Cohen KA, Keck A, Vandalfsen JM, Magaret AS, Midamba N, Chapdu C, Gao A, Hill JE, Freeman KG, Cristinziano M, Guerrero C, Jacobs-Sera D, Lauer MJ, Viland M, Hatfull GF; Investigators of the Cystic Fibrosis NTM Consortium. Trial design of bacteriophage therapy for nontuberculous mycobacteria pulmonary disease in cystic fibrosis: The POSTSTAMP study. J Cyst Fibros. 2025 Apr 12:S1569-1993(25)00765-9. doi: 10.1016/j.jcf.2025.03.669. Epub ahead of print. PMID: 40222858.
  37. Powers JP, McIntee TJ, Bhatia A, Madlock-Brown CR, Seltzer J, Sekar A, Jain N, Hornig M, Seibert E, Leese PJ, Haendel M, Moffitt R, Pfaff ER; N3C Consortium and RECOVER-EHR. Identifying commonalities and differences between EHR representations of PASC and ME/CFS in the RECOVER EHR cohort. Commun Med (Lond). 2025 Apr 11;5(1):109. doi: 10.1038/s43856-025-00827-5. PMID: 40210986; PMCID: PMC11986062.
  38. Buhr RG, Jackson NJ, Fazio JC, Barjaktarevic I, Bateman LA, Bhatt SP, Couper DJ, Curtis JL, Dolezal BA, Drummond MB, Han MK, Hansel NN, Iyer AS, Krishnan JA, Martinez FJ, Ohar J, Paine R 3rd, Rennard SI, Smith BM, Tashkin DP, Woodruff PG, Anderson WH, Cooper CB. Characteristics Associated with Lung Function Trajectories: An Analysis of the SPIROMICS Cohort. Ann Am Thorac Soc. 2025 Apr 8. doi: 10.1513/AnnalsATS.202405-500OC. Epub ahead of print. PMID: 40198759.
  39. Li X, Feng S, Yang Y, Liang Z, Song A, Chen J, Guo Z, Chen Z, Miao C, Yang H, He W, Zhou Z, Drummond MB, Chen R, Wang F. Association Between Airway Mucus Plugs and Risk of Moderate-to-Severe Exacerbations in Patients With COPD: Results From a Chinese Prospective Cohort Study. Chest. 2025 Apr 8:S0012-3692(25)00421-0. doi: 10.1016/j.chest.2025.03.026. Epub ahead of print. PMID: 40210091.
  40. Neiens V, Hansbauer EM, Jaquin TJ, Peper-Gabriel JK, Mahavadi P, Snyder ME, Grill MJ, Wurzenberger C, Konitsiotis A, Estrada-Bernal A, Heinig K, Fysikopoulos A, Schwenck N, Grüner S, Bartoschek D, Mosebach T, Kerstan S, Wrennall J, Richter M, Noda K, Hoetzenecker K, Burgess JK, Tarran R, Wurzenberger C, Wichmann KR, Biehler J, Müller KW, Guenther A, Eickelberg O, Fitzgerald MF, Olwill SA, Matschiner G, Pavlidou M. Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment. Nat Commun. 2025 Apr 5;16(1):3251. doi: 10.1038/s41467-025-58568-x. PMID: 40185752; PMCID: PMC11971276.
  41. Nguyen VL, Eick KL, Gan M, Miner TA, Friedland AE, Carey AF, Olivier KN, Liu Q. Macrolide resistance in Mycobacterium abscessus: current insights and future perspectives. JAC Antimicrob Resist. 2025 Apr 2;7(2):dlaf047. doi: 10.1093/jacamr/dlaf047. PMID: 40177306; PMCID: PMC11961302.
  42. Rodriguez D, Equilia S, Roca C, Ludi E, Espada G, García Z, Machuca B, Clark T, Gilman RH. Antimicrobial Resistance in Hospital-acquired Bloodstream Infections among Children in a Pediatric Hospital in Bolivia. J Glob Infect Dis. 2025 Mar 31;17(1):10-16. doi: 10.4103/jgid.jgid_130_24. PMID: 40290199; PMCID: PMC12021353.
  43. Edwards DA, Edwards A, Li D, Wang L, Chung KF, Bhatta D, Bilstein A, Hanes J, Endirisinghe I, Freeman BB, Gutay M, Livraghi-Butrico A, Button B. Global warming risks dehydrating and inflaming human airways. Commun Earth Environ. 2025;6(1):193. doi: 10.1038/s43247-025-02161-z. Epub 2025 Mar 17. PMID: 40678270; PMCID: PMC12269886.

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