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Marsico Lung Institute Publications for December 2025 & January 2026

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Marsico Lung Institute faculty, postdoc, student, and collaborator publications for December 2025 and January 2026 included papers appearing in Nucleic Acids Research, European Respiratory Journal, and GigaScience. Check out the full list below:

  1. Leigh MW, Shapiro AJ, Chawla KK, Hazucha MJ, Brown DE, Lin FC, Jiang L, Carson JL, Davis SD, Dell SD, Sagel SD, Rosenfeld M, Milla C, Sullivan KM, Zariwala MA, Ferkol TW, Knowles MR; Genetic Disorders of Mucociliary Clearance Consortium. Tidal Breathing Nasal Nitric Oxide Measurement as a Test for Primary Ciliary Dyskinesia in Young Children. Eur Respir J. 2026 Jan 29:2501540. doi: 10.1183/13993003.01540-2025. Epub ahead of print. PMID: 41611251.
  2. Shirley Bezerra M, Zemel BS, Gallop RJ, Walega R, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Narkewicz MR, Rowe SM, Sagel SD, Schwarzenberg SJ, Solomon GM, Chan CL, Kelly A; PROMISE Endocrine Sub-study Group. Longitudinal changes in bone mineral density after initiation of elexacaftor-tezacaftor-ivacaftor in youth and adults with cystic fibrosis: PROMISE-ENDO. J Cyst Fibros. 2026 Jan 29:S1569-1993(26)00025-1. doi: 10.1016/j.jcf.2026.01.006. Epub ahead of print. PMID: 41617582.
  3. Viswanathan G, Hughes EJ, Gan M, Xet-Mull AM, Lowy JP, Pyle CJ, Alexander G, Swain-Lenz D, Liu Q, Tobin DM. Granuloma dual RNA-seq reveals composite transcriptional programs driven by neutrophils and necrosis within tuberculous granulomas. Sci Adv. 2026 Jan 23;12(4):eadw4619. doi: 10.1126/sciadv.adw4619. PMID: 41564181; PMCID: PMC12822655.
  4. Joy N, Deshpande A, Lingamallu SM, Prabantu VM, Naveenkumar CN, Bharathkumar K, Bhat S, Alvarado-Martinez Z, Livraghi-Butrico A, Hagood JS, Boucher RC, Lafkas D, Byrd KM, Narayanan S, Shandil RK, Guha A. Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lung. Life Sci Alliance. 2026 Jan 22;9(3):e202503268. doi: 10.26508/lsa.202503268. PMID: 41571441; PMCID: PMC12827581.
  5. Lamichhane R, Choudhary I, Singamsetty D, Patial S, Saini Y. Tristetraprolin protects against ozone-induced acute lung injury and inflammation in mice. J Immunol. 2026 Jan 21;215(1):vkaf221. doi: 10.1093/jimmun/vkaf221. PMID: 41379025; PMCID: PMC12836256.
  6. Rollins SD, Hume AJ, Chen DY, Yeboah RL, Singh Bawa P, Simone-Roach C, Yin J, Little A, Fatima A, Murano H, Padua Tavares LP, Okuda K, Huang J, Kotton DN, Saeed M, Mühlberger E, Wang R. Genetic and chemical correction of cystic fibrosis reduces airway susceptibility to SARS-CoV-2. Am J Physiol Lung Cell Mol Physiol. 2026 Jan 20. doi: 10.1152/ajplung.00223.2025. Epub ahead of print. PMID: 41556834.
  7. Velez AZ, Radin JN, Kennedy EN, Parsons JB, Tong HM, Jung E, Alam E, Radlinski LC, Wagner NJ, Fowler VG Jr, Rowe SE, Kehl-Fie T, Conlon BP. The innate immune protein calprotectin ablates the bactericidal activity of β-lactam antibiotics. Proc Natl Acad Sci U S A. 2026 Jan 20;123(3):e2513462123. doi: 10.1073/pnas.2513462123. PMID: 41533443; PMCID: PMC12818397.
  8.  Groza T, Marcello AJ, Carlisle T, Lim WK, Haendel M, Karnani N, Robinson PN, Graessner H, Chong JX, Baynam G, Jamuar SS. A systematic assessment of large language models’ knowledge of rare diseases: How much do large language models know about rare disease? HGG Adv. 2026 Jan 15;7(1):100558. doi: 10.1016/j.xhgg.2025.100558. PMID: 41383021; PMCID: PMC12796007.
  9. Westcott NM, Ly M, Van Dorsten A, Worden CP, Benaim EH, Ebert C Jr, Vuncannon JR, Thorp BD, Klatt-Cromwell CN, DeMason CE, Rebuli M, Jaspers I, Senior B, Kimple AJ. Assessment of Lifetime Inhalational Exposure Burden and Associations With Chronic Rhinosinusitis. Int Forum Allergy Rhinol. 2026 Jan 15:10.1002/alr.70104. doi: 10.1002/alr.70104. Epub ahead of print. PMID: 41537742; PMCID: PMC12834482.
  10. Liu CM, Fischer JL, Overdevest JB, Zemke AC, Strand MJ, Gudis DA, Kimple AJ, Tervo JP, DiMango E, Goralski JL, Keating C, Senior B, Stapleton AL, Taylor-Cousar JL, Beswick DM. Psychometric validity of the 22-item sinonasal outcome test in cystic fibrosis. J Cyst Fibros. 2026 Jan 14:S1569-1993(25)02553-6. doi: 10.1016/j.jcf.2025.12.022. Epub ahead of print. PMID: 41535163.
  11. Zhang Y, Silvestre-Roig C, Fu H, Alimohamadi H, Mandal T, Chen JW, Luo EW, Anda J, Linard Matos AL, Richter M, Mennella A, Lee H, Chan LC, Wang Y, Wang N, Wang H, Wang X, Lee CK, Ghosh S, Matsui T, Weiss TM, Guo T, Zhang M, Li D, Wolfgang MC, Hagan RS, Li MMH, Gunzer M, Sickmann A, Frasca L, Yeaman MR, Lande R, Cui Q, Soehnlein O, Wong GCL. SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting. Proc Natl Acad Sci U S A. 2026 Jan 13;123(2):e2521841122. doi: 10.1073/pnas.2521841122. PMID: 41505524; PMCID: PMC12799121.
  12. Hoppe JE, Paisley A, Vigers T, Moffett K, Indihar V, Dasenbrook E, Mortensen JE, Muhlebach MS, Siracusa C. Reliability of clinic-obtained versus self-obtained respiratory samples from the Self-Sample Accuracy and Benefit Implementation Trial (S2wAB-IT). Chest. 2026 Jan 12:S0012-3692(26)00011-5. doi: 10.1016/j.chest.2025.12.036. Epub ahead of print. PMID: 41534707.
  13. Mao Y, Patial S, Saini Y. Myeloid cell-specific HMGB1 deficiency exaggerates mucoinflammatory responses but promotes bacterial clearance in mucoinflammatory lung disease. Sci Rep. 2026 Jan 12;16(1):3391. doi: 10.1038/s41598-025-33357-0. PMID: 41526418; PMCID: PMC12834952.
  14. Yamamoto S, Niitsu T, Fukushima K, Shiozawa A, Imai R, Hashimoto K, Olivier KN, Aksamit TR, Morimoto K. Efficacy of Anti-Inflammatory Therapies for Adults with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review and Network Meta-Analysis. Chest. 2026 Jan 12:S0012-3692(26)00010-3. doi: 10.1016/j.chest.2025.12.035. Epub ahead of print. PMID: 41534709.
  15. Rekerle L, Danis D, Rehburg F, Graefe ASL, Bily V, Caballero-Oteyza A, Cacheiro P, Chimirri L, Chong JX, Connelly E, de Vries BBA, Dingemans AJM, Duyzend MH, Freiberger T, Gehle P, Groza T, Hansen P, Jacobsen JOB, Klocperk A, Ladewig MS, Love MI, Marcello AJ, Mordhorst A, Munoz-Torres MC, Reese J, Schuetz C, Smedley D, Strauss T, Vladyka O, Zocche D, Thun S, Mungall CJ, Haendel MA, Robinson PN. GA4GH phenopacket-driven characterization of genotype-phenotype correlations in Mendelian disorders. Am J Hum Genet. 2026 Jan 8;113(1):57-70. doi: 10.1016/j.ajhg.2025.12.001. PMID: 41443197; PMCID: PMC12824607.
  16. DeLuca M, Matentzoglu N, Sharp E, Li J, Hempstead C, Lim M, Kaniewski P, Carter EK, Koirala K, Ding E, Vijnck L, Brokmeier P, Toro S, Schaper K, Vergine J, Li O, Oprea TI, Fajgenbaum DC, Bizon C, Haendel M, Tropsha A. Medicines, Diseases, Indications, and Contraindications (MeDIC): a foundational resource to support drug repurposing. Nucleic Acids Res. 2026 Jan 6;54(D1):D1477-D1487. doi: 10.1093/nar/gkaf1312. PMID: 41385096; PMCID: PMC12807713.
  17. Vo T, Choudhary I, Patial S, Saini Y. Single-cell transcriptomics reveal alveolar macrophages-specific responses in single-hit ozone exposure model in mice. Am J Physiol Lung Cell Mol Physiol. 2026 Jan 2. doi: 10.1152/ajplung.00235.2025. Epub ahead of print. PMID: 41481288.
  18. Gannarapu S, Abu-Hijleh M, Zariwala MA, Afolabi F, Gelfand AS, Vece TJ, Rivera-Sanchez YM. A Pediatric Patient With PCD and Broncholith Formation. Pediatr Pulmonol. 2026 Jan;61(1):e71469. doi: 10.1002/ppul.71469. PMID: 41566686.
  19. Kirstein J, Rosenzweig R, De Los Rios P, Genevaux P, Adang C, Andreasson C, Balchin D, Barducci A, Blatch GL, Braun JEA, Brodsky JL, Bukau B, Chapple JP, Cheetham ME, Craig EA, Cyr DM, Dementin S, Faust O, Genest O, Gestwicki JE, Goloubinoff P, Grabinska-Rogala A, Hammond CM, Inoue M, Jiang Y, Joachimiak LA, Kasai A, Klosowska A, Lee HO, Liberek K, Musskopf MK, Linse S, Mayer MP, Mogk A, Mokranjac D, Münch C, Rebeaud ME, Rospert S, Sanagavarapu K, Sahi C, Shalgi R, Sutandy FXR, Tomiczek B, Ushioda R, Weihl CC, Ying Z, Marszalek J, Kampinga HH. J-domain proteins: from molecular mechanisms to diseases. Cell Stress Chaperones. 2025 Dec 19;31(1):100142. doi: 10.1016/j.cstres.2025.100142. Epub ahead of print. PMID: 41422864.
  20. Mittal K, Duan W, Thanikachalam S, Schichlein K, Jaspers I, Clapp PW, Moraes TJ. Propylene glycol and vegetable glycerin e-cigarette aerosols impact mucociliary function and cause cytotoxicity in human airway epithelium. Sci Rep. 2025 Dec 19;16(1):3158. doi: 10.1038/s41598-025-33023-5. PMID: 41420077; PMCID: PMC12830841.
  21. Wilgus ML, Edmonds A, Keller KP, Elf JL, Abraham AG, Bhatt SP, Buhr RG, Cohen MH, Detels R, Drummond MB, Fischl MA, Foronjy R, Hosgood HD, Huang L, Kunisaki KM, McCormack M, Morris A, Raju S, Ramirez C, Rudolph J, Stosor V, Tashkin DP, Visconti A, Weiser SD, Wingood G, Barjaktarevic I. Greater ambient air pollution exposure is associated with worse respiratory symptoms in men and women with HIV and chronic lung disease: a cohort study. Respir Res. 2025 Dec 19;26(1):349. doi: 10.1186/s12931-025-03398-0. PMID: 41420180; PMCID: PMC12717705.
  22. Cao S, Shrivastav A, Bleecker ER, Madapoosi S, Erb-Downward J, Zein J, Chen X, Howard TD, Hawkins GA, Barjaktarevic IZ, Bowler R, Barr RG, Comellas A, Cooper CB, Couper D, Han M, Hansel NN, Hastie AT, Kaner R, Kanner RE, Kim V, Martinez FJ, Moore WC, O’Neal WK, Paine R, Smith B, Hoffman EA, Meyers DA, Woodruff PG, Christenson S, Curtis JL, Huang YJ, Ortega VE. Epigenomic study of the lower airway reveals COPD-associated methylation patterns and potential microbiota links. BMJ Open Respir Res. 2025 Dec 18;12(1):e003572. doi: 10.1136/bmjresp-2025-003572. PMID: 41419234; PMCID: PMC12716595.
  23. Shwetar YJ, Lalush DS, Zhang AY, McAnany JJ, Jeffrey BG, Haendel MA. A practical introduction to wavelet analysis in electroretinography. Doc Ophthalmol. 2025 Dec 15. doi: 10.1007/s10633-025-10070-x. Epub ahead of print. PMID: 41398515.
  24. Yeasin M, Akash MMH, Malakar A, Borojeni AAT, Tummala A, Wu J, Bennett WD, Bodnar WM, Kimbell JS, Chakravarty A, Port JR, Basu S. Decoding the mechanophysiology for inhaled onset of smallpox with model-based implications for mpox spread. Sci Rep. 2025 Dec 14;16(1):2142. doi: 10.1038/s41598-025-31923-0. PMID: 41392049; PMCID: PMC12808741.
  25. Moxon SAT, Solbrig H, Harris NL, Kalita P, Miller MA, Patil S, Schaper K, Bizon C, Caufield JH, Cuesta SC, Cox C, Dekervel F, Dooley DM, Duncan WD, Fliss T, Gehrke S, Graefe ASL, Hegde H, Ireland AJ, Jacobsen JOB, Krishnamurthy M, Kroll C, Linke D, Ly R, Matentzoglu N, Overton JA, Saunders JL, Unni DR, Vaidya G, Vierdag WAM, Ruebel O, Chute CG, Brush MH, Haendel MA, Mungall CJ. LinkML: An Open Data Modeling Framework. Gigascience. 2025 Dec 12:giaf152. doi: 10.1093/gigascience/giaf152. Epub ahead of print. PMID: 41384800.
  26. Schichlein KD, Kim HH, Porter NA, Jaspers I. 7-OH and Kratom Vaping Products: An Emerging Public Health Threat. Toxicol Sci. 2025 Dec 12:kfaf169. doi: 10.1093/toxsci/kfaf169. Epub ahead of print. PMID: 41385306.
  27. Atanasiu AT, Hult C, Kolbin D, Walker BL, Forest MG, Yeh E, Bloom K. The Role of Transient Crosslinks in the Chromatin Search Response to DNA Damage. Int J Mol Sci. 2025 Dec 3;26(23):11697. doi: 10.3390/ijms262311697. PMID: 41373843; PMCID: PMC12692392.
  28. Yang H, Fang S, Yang Y, Chen G, Zha S, Miao C, Chen Z, Li X, Zhou Z, He W, Yu Y, Liu F, Wu Y, Wang F, Drummond MB, Zhong N, Chen R, Liang Z. Association of respiratory symptom profiles with future exacerbations and lung function decline in mild-to-moderate COPD. BMJ Open Respir Res. 2025 Dec 2;12(1):e003643. doi: 10.1136/bmjresp-2025-003643. PMID: 41338594; PMCID: PMC12673541.
  29. Hong G, Walsh J, Koshy A, Hsu JY, O’Dea AL, Vesely EM, Memon W, Dezube RH, Goss CH, Goss LB, Greene A, Gross JE, Wilson A, Nichols DP, Zhang SX, Cramer RA. Home sputum collection for Aspergillus fumigatus detection in adults with cystic fibrosis. ERJ Open Res. 2025 Dec 1;11(6):00272-2025. doi: 10.1183/23120541.00272-2025. PMID: 41333983; PMCID: PMC12666647.
  30. Mansour S, Slimmen LJM, Silva GL, Collins GL, Giacalone VD, Margaroli C, H A N Manai B, Mager D, Estevão SC, Kim SO, Moncada-Giraldo D, Lyles JT, W J Unger W, Peng L, Esther CR, Caudri D, Rao P, Shanthikumar S, Ranganathan S, Stick SM, Guglani L, Tirouvanziam R, Janssens HM, Chandler JD. Early life elevations of methionine oxidation and ornithine track and predict cystic fibrosis structural lung disease. ERJ Open Res. 2025 Dec 1;11(6):00238-2025. doi: 10.1183/23120541.00238-2025. PMID: 41367653; PMCID: PMC12683548.
  31. Williams CL, Ansar M, Zhou JJ, Ceppe A, LiPuma JJ, Saiman L, Muhlebach MS. Provider Knowledge of 2013 Cystic Fibrosis Infection Prevention and Control Guidelines for Outpatient Care. Pediatr Pulmonol. 2025 Dec;60(12):e71439. doi: 10.1002/ppul.71439. PMID: 41449781.
  32. Zhang YD, Wu CH, Shi HX, Merlitz H, Bloom KS, Forest MG, Wu CX, Cao XZ. Tuning nuclear rheology through transient chromatin cross-links. Phys Rev E. 2025 Dec;112(6-1):064403. doi: 10.1103/tn2w-kzb8. PMID: 41560264.

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