In recognition of National Diabetes Month, the Division of Endocrinology and Metabolism highlights its groundbreaking research efforts through the EnDO CRU (Endocrinology, Diabetes, and Obesity Clinical Research Unit). Under the leadership of Dr. Klara Klein, the unit currently conducts over 20 active studies targeting type 1 and type 2 diabetes, as well as obesity.
Pioneering Therapies for Type 1 Diabetes
In the realm of type 1 diabetes, the team is testing innovative therapies aimed at improving glycemic control and cardiometabolic health. These include a novel insulin formulation and an oral therapy designed to enhance glycemia while reducing hypoglycemia risk. Additional studies explore treatments that could aid in weight management and mitigate diabetic kidney disease.
Advancing Type 2 Diabetes Treatment
For type 2 diabetes, the EnDO CRU is evaluating over three cutting-edge incretin-based therapies. These treatments aim to revolutionize weight management, glycemic control, and cardiovascular health for patients with type 2 diabetes.
Investigating the Link Between Sleep and Glucose Regulation
A collaborative study led by Dr. Janice Hwang, chief of the UNC Division of Endocrinology and Metabolism, in partnership with Dr. Jane Fan from Neurology and Dr. Leping Li from NIEHS, is delving into how type 2 diabetes affects sleep brain waves. Sleep’s role in glucose regulation is vital, with specific brain waveforms—such as slow oscillations, spindles, and sharp wave-ripples—being essential for maintaining glucose homeostasis. Early findings indicate that type 2 diabetes may disrupt these waveforms, impairing glucose regulation. This research could pave the way for innovative diabetes management strategies focusing on sleep health.
Exploring Diabetes and Brain Development in Youth
In another significant initiative, a multidisciplinary team comprising Dr. Aysenil Belger (Psychiatry), Dr. Nina Jain (Pediatric Endocrinology), and Dr. Janice Hwang has received NIH funding to investigate how newly diagnosed type 1 diabetes impacts brain development over time. This longitudinal study will examine how the disease influences brain function, providing critical insights for managing young patients.
The Division of Endocrinology and Metabolism remains at the forefront of diabetes research, fostering collaborations and advancing therapies to improve patient outcomes. As National Diabetes Month emphasizes awareness and progress, these initiatives underscore the importance of scientific innovation in combating this global health challenge.