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Function, expression and trafficking GABA-A receptors in the CNS; effects of chronic ethanol exposure that leads to ethanol tolerance and dependence; role of endogenous neurosteroids on ethanol action and ethanol-induced adaptations. Role of neuroactive steroids in neuropsychiatric disease, including addiction, depressive disorders, anxiety disorders, inflammatory disorders.,Function, expression and trafficking GABA-A receptors in the CNS; effects of chronic ethanol exposure that leads to ethanol tolerance and dependence; role of endogenous neurosteroids on ethanol action and ethanol-induced adaptations. Role of neuroactive steroids in neuropsychiatric disease, including addiction, depressive disorders, anxiety disorders, inflammatory disorders.


UNC AFFILIATIONS:

Bowles Center for Alcohol Studies, Pharmacology, Psychiatry, Toxicology

CLINICAL/RESEARCH INTERESTS:

Cell Biology, Neurobiology, Pharmacology, Toxicology, Translational Medicine

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