- Cell motility, migration, cancer metastasis
My lab focuses on actin-based cell motility. Actin-based motility is a key component in many cellular processes relevant to clinical problems such as cancer metastasis, birth defects and compromised immune function. We are using both molecule-based and unbiased genetic/proteomic approaches to understand the fundamental problem of cell migration and other aspects of actin-based motility. We utilize the techniques of high-resolution live cell microscopy, biochemistry, gene silencing/disruption and other molecular manipulations to uncover some of the underlying mechanisms of cell motility.