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Postdoctoral and Staff Research Positions in the Hahn Lab, University of North Carolina at Chapel Hill

Four images R to L: Engineered allosteric control - Visualing/controlling molecules in living cells; small molecules report protein activity in vivo; and two images related to Modeling phagocytosis based on biosensors and optogenetics.

Postdoctoral positions are available to study the changing structure and signaling of adhesions, podosomes and other dynamic organelles. We develop proteins and small molecules that reveal and control cell function during microscopy of living cells and tissues. Our current focus is on macrophages and the cancer microenvironment, synthetic biology to respond to cell morphology, and the signaling circuits described below. For further information see

  • Engineer proteins to visualize and control the conformation of individual molecules in living cells. Thereby explore the dynamics of adhesion complexes in metastasis and immune function.
  • Develop novel biosensors and optogenetic protein analogs to study the spatio-temporal dynamics of GTPase and kinase signaling. Complex, nonlinear regulatory circuits will be dissected using image analysis and modeling approaches developed with our collaborator Gaudenz Danuser (UTSW). This is potentially part of a new national imaging center bridging three laboratories. Danuser Lab.
  • Harness organic chemistry to develop novel biosensors for single molecule imaging in live cells. These will be based on environment-sensing dyes and methods to covalently label proteins in vivo. This project can provide a platform for organic and physical organic chemists to apply and extend their knowledge, working in protein engineering and microscopy.
  • We seek staff members to collaborate with users applying molecular imaging tools. Experience with cutting edge microscopy and any of the following would be helpful: advanced microscopes / microscope automation and alignment / biosensors / chemogenetics / optogenetics / image analysis / lasers / optics. Positions at the BS or PhD level are available.

The University of North Carolina is a multidimensional research center with over $510 million in federal funding, making us the 11th largest research university in the United States. Our Pharmacology department was ranked #2 in the world for “Best Global Universities for Pharmacology & Toxicology”, and we are proud of the Nobel prizes awarded to our science faculty in 2015 and 2019.

If you are interested in any of these positions, please send a CV and brief description of career and research goals to

~Update posted 4/21/2022

The University of North Carolina at Chapel Hill Department of Pharmacology, Computational Medicine Program Assistant Professor (Tenure Track)

Position Summary

The Computational Medicine Program and Department of Pharmacology at the University of North Carolina at Chapel Hill (UNC-CH) invite applicants for a tenure-track faculty position in Computational Medicine. The Computational Medicine Program at UNC-CH is a newly established research initiative that seeks to integrate modern computational approaches, including mathematical modeling, machine learning, and network analysis, with cutting-edge experimental techniques to address problems relevant to human health. While the area of study is flexible, an ideal candidate would apply methods from systems biology to investigate the molecular mechanisms dysregulated in human diseases, and to eventually develop predictive models of these disease states. The successful candidate will hold a position, and research laboratory space, within the Computational Medicine Program, and also hold a position within the Department of Pharmacology. They will be expected to direct an independent research program supported by extramural funding, and participate in team science projects initiated through the Computational Medicine Program. The successful candidate will also participate in graduate student mentoring and teaching at the graduate level.

Educational Requirements

Doctoral Degree and 3-6 years of postdoctoral experience in pharmacology, computational/mathematical biology, biophysics or a related field.

Qualifications and Experience

Strong training and experience in applying computational and quantitative approaches to problems in biomedical research. It is anticipated that some candidates may be entirely computational, while others will incorporate an experimental component into their research; both types are eligible and encouraged to apply.

To apply

Please upload your C.V., cover letter, research statement, and list of at least four professional references here:

The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or status as a protected veteran.