"Scleroderma: toward emerging therapeutic strategies" Dr. John Varga Rheumatology Division Chief University of Michigan Virtual (Zoom) URL: https://zoom.us/j/92101985767?pwd=d3hHbWhHMFlQSm05RmdCVVVmMkVIUT09 Meeting ID: 921 0198 5767 Passcode: 005755 Phone (New York): 929-205-6099 Phone (Toll-free): 888-475-4499
Proteostasis: Does it have a role in osteoarthritis? Brief description: Loss of proteostasis is one of the hallmarks of aging. We found that aging reduces the expression of molecular chaperones in chondrocytes resulting in cellular stress and inflammation, which could contribute to the development of osteoarthritis. Dr. Raghunatha Yammani Associate Professor, Molecular Medicine Wake Forest … Read more
"Genomic Approaches to Understanding the Genetic Risk of Osteoarthritis" Genome-wide association studies (GWAS) have identified over 100 osteoarthritis (OA)-associated loci; however, translating these broad loci into actionable therapeutic targets requires identifying the causal variants, the gene(s) they affect, and their mechanistic impact on OA risk. We apply genomic, bioinformatics, and genome editing approaches to identify … Read more
"Genes and regulatory variants for cardiometabolic traits" Brief Description: Human genome-wide association studies identify genomics regions relevant to disease risk, although the underlying risk variants and genes can remain unclear. This presentation will describe use of genetic variants associated with gene expression and/or chromatin accessibility to identify putative disease genes, variants and molecular mechanisms. Karen … Read more
Presentation Title: "Orthopedic Translational Medicine: Horses, Humans and the Pursuit of Joint Health" Brief description: Post-traumatic Osteoarthritis (PTOA) is extremely common in equine athletes as well as humans. The horse is an incredible translational model and has been utilized for decades to inform equine clinicians treating their patients and MD’s treating people with PTOA. Further, … Read more
"The Skeleton in a Physical World" Brief Description: All organisms exist within a physical space and respond to physical forces as part of daily life. The skeleton responds in real-time to physical stresses placed on it to ensure that its structure supports its function. I will discuss how those cells responsible for remodeling skeletal structure … Read more
"DNA damage and cellular senescence in osteoarthritis pathophysiology.” Brief Description: Aging is the largest risk factor for osteoarthritis, but the mechanisms responsible for this relationship are unclear. Damaged cells can convert to a phenotypic state known as cellular senescence, and senescent cells are associated with compromised tissue function. This talk will focus on our efforts … Read more
"Neuroplasticity in the knee joint: More than just pain." Brief Description: I will describe the sensory innervation of the joint, its anatomical and molecular properties, and how these properties change in the course of osteoarthritis (=neuroplasticity). I will discuss the biological role of this neuroplasticity in pain and in joint homeostasis. Anne-Marie Malfait, MD, PhD … Read more
"Novel mechanisms of microRNA-mediated anabolic effects in osteoarthritis" Brief Description: Through the novel use of in vivo protein deamidation molecular clocks, we unmasked a position-dependent gradient of protein anabolism in human lower limb cartilages. This gradient is strikingly associated with the expression of evolutionarily-conserved limb-regenerative miRNAs. This association shows a potential link to a capacity … Read more
"The Genomic Etiology of Osteoarthritis" Brief Description: Osteoarthritis is one of the leading causes of disability and pain worldwide, with over 300 million people affected. Currently no curative treatments are available. A detailed un-derstanding of disease aetiopathology and novel drug targets are therefore urgently needed. In this talk, I will give an overview of how … Read more