Oct 01, 2013
from 11:00 AM to 12:00 PM
|Contact Name||Rhonda Scott|
open to the public
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Associate Professor of Biochemistry
Associate Professor of Medical Biochemistry at the College of Medicine
University of Illinois Urbana-Champaign
SEMINAR: "Epigenetic regulation of NF-kappaB in Cancer and immunity"
Host: Greg Wang, PhD
Text of Podcast
Hello! Welcome to the science seminar preview from the Department of Biochemistry and Biophysics at the University of North Carolina at Chapel Hill. I’m Ashley Kretsch, a first year student in the Biological and Biomedical Science PhD Program. I’m here to tell you about a seminar that will have your brain tingling in excitement for scientific advancement! On Tuesday, October 1st, Dr Chen, from the University of Illinois at Urbana-Champaign, will speak on "Epigenetic regulation of NF-kappaB signaling in Cancer and immunity". NF-kappaB? Scientists might recognize it as a big buzzword heard throughout the cancer community. Combating cancer through understanding its mechanisms is one of the greatest medical battles of this century. By understanding a beast such as NF-kappaB and its involvement in cancer, we have another tool in the cancer treatment toolbox. But what is NF-kappaB? NF-kappaB is a eukaryotic transcription factor that regulates genes involved in inflammatory and immune responses, programmed cell death, and cell proliferation and differentiation. In particular, it can be a key player to initiation and progression of cancer. Dr. Chen studies regulation of NF-kappaB, in particular its activation. The permanently active form of NF-kappaB is found in different solid tumors and hematologic malignancies. Dr. Chen studies the acetylation of the RelA subunit of NF-kappaB, which regulates its translational activation. Dr. Chen has exciting new evidence that a novel function of Bromodomain-containing factor Brd4 is maintaining NF-kappaB in a persistently active form that has been found in tumors. Who knows, this could be a potential new therapy for cancer! Please join us for Dr. Chen’s seminar at 11am in 1131 Bioinformatics to find out more about his latest findings!