Professor of Chemistry, UNC-CH Professor of Biochemistry and Biophysics Professor of Microbiology and Immunology Director of Structural Biology Member of Program in Molecular Biology and Biotechnology Member of the Lineberger Comprehensive Cancer Center PHD - University of California, Los Angeles (click for Full Publication List)

HONORS & AWARDS

Academic Leadership Fellow (2010)
Hettleman Prize (2006)
Burroughs Wellcome Career Award (1999)

RESEARCH

Summary:

The focus of the Redinbo Lab is the examination of the structural and functional basis of cellular function with an eye toward human health. Current projects include discovery and development of drugs that improve chemotherapeutic efficacy for cancer and other diseases, and elucidation of the mechanisms of antibiotic resistance propagation in infectious pathogens. Basic science goals include understanding DNA manipulation and processing, transcription, and protein function during infection and disease.

Core Techniques:

Structural biology, chemical biology, biochemistry, molecular biology, microbiology, cell biology, drug discovery.

REPRESENTATIVE PUBLICATIONS

• Wallace, B.D., Wang, H., Lane, K.T., Scott, J.E., Orans, J., Koo, J.S., Venkatesh, M., Jobin, C., Yeh, L.-A., Mani, S., and Redinbo, M.R. (2010).  Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.  Science, 330, 831-835.
• Orans, J., Johnson, M.D.L., Coggan, K.A., Sperlazza, J.R., Heiniger, R.W., Wolfgang, M.C., and Redinbo, M.R. (2010). Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility. Proceedings of the National Academy of Sciences USA, 107, 1065-1070.

CONTACT INFO

B929 Kenan Labs
Campus Box # 3290
Chapel Hill, NC 27599

Office: 919-843-8910
Lab: 919-962-7576
Fax: 919-962-2388

redinbo@unc.edu

Redinbo Lab Website