Matthew Redinbo, PhD


  • Academic Leadership Fellow (2010)
  • Hettleman Prize (2006)
  • Burroughs Wellcome Career Award (1999)



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The focus of the Redinbo Lab is the examination of the structural and functional basis of cellular function with an eye toward human health. Current projects include discovery and development of drugs that improve chemotherapeutic efficacy for cancer and other diseases, and elucidation of the mechanisms of antibiotic resistance propagation in infectious pathogens. Basic science goals include understanding DNA manipulation and processing, transcription, and protein function during infection and disease.

Core Techniques:

Structural biology, chemical biology, biochemistry, molecular biology, microbiology, cell biology, drug discovery.


  • Wallace, B.D., Wang, H., Lane, K.T., Scott, J.E., Orans, J., Koo, J.S., Venkatesh, M., Jobin, C., Yeh, L.-A., Mani, S., and Redinbo, M.R. (2010).  Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.  Science, 330, 831-835.
  • Orans, J., Johnson, M.D.L., Coggan, K.A., Sperlazza, J.R., Heiniger, R.W., Wolfgang, M.C., and Redinbo, M.R. (2010). Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility. Proceedings of the National Academy of Sciences USA, 107, 1065-1070.


B929 Kenan Labs
Campus Box # 3290
Chapel Hill, NC 27599

Office: 919-843-8910
Lab: 919-962-7576
Fax: 919-962-2388

Redinbo Lab Website