The labs of Mark Zylka, Ben Major, both in the Dept. of Cell Biology and Physiology, and Mike Emanuele identified a link between the E3 ubiquitin ligase Ube3a, the proteasome, and Wnt signaling. This collaboration harnessed the Zylka labs expertise at studying an autism-linked Ube3a mutation, the Major labs expertise with proteomics and Wnt signaling, and the Emanuele’s lab expertise at identifying ubiquitinated substrates.

Study was published online in the Journal of Biological Chemistry.