Faculty News

How do adult brain circuits regulate new neuron production?

How do adult brain circuits regulate new neuron production?

In a new study published in Cell Stem Cell, UNC School of Medicine neuroscientist Juan Song and colleagues discovered a long-distance brain circuit that controls the production of new neurons in the hippocampus.

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Brian Jensen Receives The Hyman Battle Distinguished Excellence in Teaching Award and Delivers Whitehead Lecture

Brian Jensen Receives The Hyman Battle Distinguished Excellence in Teaching Award and Delivers Whitehead Lecture

Brian Jensen, MD, assistant professor of medicine and pharmacology, delivered the 2017 Whitehead Lecture. The event, which serves as an unofficial convocation of the UNC School of Medicine, has been held annually since 1947.

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Mackman to lead 4-year $1.5-million award study into role of clotting protease and receptor in the innate immune response to viral infections

Mackman to lead 4-year $1.5-million award study into role of clotting protease and receptor in the innate immune response to viral infections

UNC receives $1.5-million grant to study the role of a clotting protease and receptor in the innate immune response to viral infections. Nigel Mackman, PhD, Distinguished Professor of Medicine, and joint Professor of Pharmacology, is the principal investigator of a 4-year $1.5-million award from the National Heart Lung and Blood Institute. This grant will determine the role of thrombin activation of protease-activated receptor 1 in the innate immune response to viral infections.

Mackman to lead 4-year $1.5-million award study into role of clotting protease and receptor in the innate immune response to viral infections - Read More…

Willis laboratory recognized by Society of Endocrinology for excellence in endocrine research

Willis laboratory recognized by Society of Endocrinology for excellence in endocrine research

The Willis laboratory has been recognized by the Society of Endocrinology for excellence in endocrine research and practice and for contributions to the wider biomedical and biological sciences field. The award was chosen by a panel on the basis of originality, scientific content, presentation and contribution to the field. The award will be presented to Monte Willis, PhD, at the Society’s Annual BES Conference in Harrogate, UK on November 7.

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In ovarian cancer, researchers uncover new drivers of cell division

In ovarian cancer, researchers uncover new drivers of cell division

UNC Lineberger's Michael J. Emanuele, PhD, and colleagues have identified a key activator that can turn on FoxM1, a protein that drives expression of genes that help cells replicate and divide, a finding they published in the journal Molecular and Cellular Biology. They also discovered, paradoxically, that the activator for FoxM1 is also responsible for turning this protein off.

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Leslie Parise elected UNC-Chapel Hill Faculty Chair

Leslie Parise elected UNC-Chapel Hill Faculty Chair

Parise is completing a second term on the Faculty Executive Committee (FEC) and Faculty Council, where she pushed for improvements to the campus work-life environment and initiated discussions that led to creation of the Chancellor’s Science Scholars Program in the College of Arts and Sciences.

Leslie Parise elected UNC-Chapel Hill Faculty Chair - Read More…

H. Shelton Earp recognized for career achievements in cancer research

H. Shelton Earp recognized for career achievements in cancer research

H. Shelton Earp, MD, Director of UNC Cancer Care and the Lineberger Professor of Cancer Research, and Joint Professor of Pharmacology has been honored with the Hyman L. Battle Distinguished Cancer Research Award along with Jenny P.Y. Ting, PhD, UNC Lineberger member and William Rand Kenan Professor of Genetics,

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Researchers awarded grant to study strategy to improve immunotherapy response

Researchers awarded grant to study strategy to improve immunotherapy response

With a $1.74 million grant from the NIH, UNC Lineberger researchers led by H. Shelton Earp, MD, will study a potential new strategy for improving immunotherapy drug responses in patients with melanoma.

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 Ganglionic GFAP+ glial Gq-GPCR signaling enhances heart functions in vivo

Ganglionic GFAP+ glial Gq-GPCR signaling enhances heart functions in vivo

Alison Xiaoqiao Xie, research assistant professor in Ken McCarthy's lab, is first author on paper published in JCI Insight this week. Ken D. McCarthy, professor of pharmacology, is senior author and Jakovin J. Lee, is a co-author.

Ganglionic GFAP+ glial Gq-GPCR signaling enhances heart functions in vivo - Read More…

This is LSD attached to a brain cell serotonin receptor

This is LSD attached to a brain cell serotonin receptor

For the first time, UNC School of Medicine researchers crystalized the structure of LSD attached to a human serotonin receptor of a brain cell, and they may have discovered why an “acid trip” lasts so long.

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Researchers unlock mechanism of drug resistance in aggressive breast cancer

Researchers unlock mechanism of drug resistance in aggressive breast cancer

UNC Lineberger researchers find how triple negative breast cancer cells are able to bypass treatment with trametinib, an FDA-approved drug. The researchers also used lab models of breast cancer to test a potential treatment approach that could prevent resistance.

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Inside the world of cell signaling: a G-protein breakthrough

Inside the world of cell signaling: a G-protein breakthrough

UNC scientists led by John Sondek, PhD, created a new biochemical tool to block specific types of downstream G-protein signaling, opening new avenues of research and potential drug design and discovery.

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Engineering Control of Cellular Proteins - An Ontogenetics Breakthrough

Engineering Control of Cellular Proteins - An Ontogenetics Breakthrough

UNC scientists expand the use of light to control protein activity in cells. Klaus Hahn and Nikolay Dokholyan have published a paper in Science, detailing how they use light- or ligand-sensitive domains to modulate the structural disorder of diverse proteins, thereby generating robust allosteric switches. The title of the paper is "Engineering extrinsic disorder to control protein activity in living cells."

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Scientists discover interplay of yin-yang antagonists vital for cell division

Scientists discover interplay of yin-yang antagonists vital for cell division

Although mutated versions of the protein Cdh1 have not been found in cancers, the protein’s degradation at a key moment during the cell cycle may spur on cancerous cell division.

Scientists discover interplay of yin-yang antagonists vital for cell division - Read More…