Faculty News

Scientists Create Method to Map Vast Unknown Territory of Long Non-coding RNA

Scientists Create Method to Map Vast Unknown Territory of Long Non-coding RNA

UNC School of Medicine researchers led by Mauro Calabrese, PhD, have developed a way to categorize mysterious RNA molecules by their likely function, a big first step toward quickening the discovery of their roles in human health and diseases, such as cancers

Scientists Create Method to Map Vast Unknown Territory of Long Non-coding RNA - Read More…

Johnson Honored with Battle Distinguished Cancer Research Award

Johnson Honored with Battle Distinguished Cancer Research Award

Gary Johnson, PhD, the Kenan Distinguished Professor in the UNC School of Medicine Department of Pharmacology, and co-director of UNC Lineberger’s Molecular Therapeutics Program was awarded the 2017-2018 Hyman L. Battle Distinguished Cancer Research Award.

Johnson Honored with Battle Distinguished Cancer Research Award - Read More…

 Psychoactive Drug Screening Program Renewed for Another 5 Years

Psychoactive Drug Screening Program Renewed for Another 5 Years

Congratulations to the Roth Lab for having the NIMH grant that funds the Psychoactive Drug Screening Program renewed for another 5 years!

Psychoactive Drug Screening Program Renewed for Another 5 Years - Read More…

Scientists Discover Intricacies of Serotonin Receptor Crucial for Better Therapeutics

Scientists Discover Intricacies of Serotonin Receptor Crucial for Better Therapeutics

By crystalizing a serotonin receptor bound to several common compounds, UNC School of Medicine scientists led by Bryan L. Roth discovered how slightly different drugs can cause severe side effects or none at all. The findings should accelerate the design of safer and more effective medications for a variety of conditions.

Scientists Discover Intricacies of Serotonin Receptor Crucial for Better Therapeutics - Read More…

Nicholas Brown Earns MIRA from NIH

Nicholas Brown Earns MIRA from NIH

The National Institute of General Medical Sciences awarded Nicholas G. Brown $1.25 million over five years for research aimed at investigating the regulation of the enzyme known as the Anaphase-Promoting Complex/Cyclosome (APC/C) to ultimately understand cell cycle progression.

Nicholas Brown Earns MIRA from NIH - Read More…

Can Scientists Leverage Mysterious Mossy Cells for Brain Disease Treatments?

Can Scientists Leverage Mysterious Mossy Cells for Brain Disease Treatments?

UNC School of Medicine neuroscientist Juan Song, PhD, and colleagues show how specific brain cells communicate with adult neural stem cells, a discovery that could open new investigations into potential treatments for some neurological disorders and brain injuries.

Can Scientists Leverage Mysterious Mossy Cells for Brain Disease Treatments? - Read More…

Discovery of kidney cancer driver could lead to new treatment strategy

Discovery of kidney cancer driver could lead to new treatment strategy

In a study published in the journal Science, researchers led by UNC Lineberger's Qing Zhang, Assistant Professor in the departments of Pathology & Laboratory Medicine and Pharmacology, suggest that ZHX2 is a potential new therapeutic target for clear cell renal cell carcinoma, which is the most common type of kidney cancer.

Discovery of kidney cancer driver could lead to new treatment strategy - Read More…

Dr. Bryan Roth featured as science expert on opioid and addiction podcast

Dr. Bryan Roth featured as science expert on opioid and addiction podcast

Bryan L. Roth, MD, PhD, the Michael Hooker Distinguished Professor of Pharmacology, was featured on the Naked Scientists Podcast for his work on developing pain medications without the most severe side effects.

Dr. Bryan Roth featured as science expert on opioid and addiction podcast - Read More…

Dr. Daniel Dominguez Joins Pharmacology as New Faculty Member

Dr. Daniel Dominguez Joins Pharmacology as New Faculty Member

Dr. Dominguez. who is an alumni of the Pharmacology Graduate program has joined the department as our newest Assistant Professor faculty member.

Dr. Daniel Dominguez Joins Pharmacology as New Faculty Member - Read More…

New genomic research on cardiovascular health in rural North Carolina

New genomic research on cardiovascular health in rural North Carolina

Two genomic-based studies from Heart Healthy Lenoir were published in the last month. Heart Healthy Lenoir was a multidisciplinary research project that aimed to reduce cardiovascular disease in Lenoir County, North Carolina by developing new approaches to care, from prevention to treatment. The lead investigator of the Heart Healthy Lenoir genomics study is Jonathan Schisler, PhD, assistant professor in the Department of Pharmacology and McAllister Heart Institute.

New genomic research on cardiovascular health in rural North Carolina - Read More…

How did Gonorrhea Become a Drug-resistant Superbug?

How did Gonorrhea Become a Drug-resistant Superbug?

Scientists led by Rob Nicholas, PhD, at the UNC School of Medicine show how the gonorrhea bacterium resists last-resort antibiotic ceftriaxone while maintaining a robust growth rate.

How did Gonorrhea Become a Drug-resistant Superbug? - Read More…

Jen Jen Yeh named Smithies Investigator

Jen Jen Yeh named Smithies Investigator

The UNC School of Medicine has selected Jen Jen Yeh, MD, professor and vice chair of research for the department of surgery, and joint professor of pharmacology, for one of two annual awards in honor of Oliver Smithies, UNC’s first Nobel Prize winner.

Jen Jen Yeh named Smithies Investigator - Read More…

Scientific Breakthrough Could Lead to Better Antipsychotic Drugs

Scientific Breakthrough Could Lead to Better Antipsychotic Drugs

Published in Nature, research from the lab of Bryan L. Roth, MD, PhD, Distinguished Professor of Pharmacology, revealed the first-ever crystal structure of the dopamine 2 receptor bound to an antipsychotic drug – a much-needed discovery in the quest to create effective drugs with fewer side effects to treat bipolar disorder, schizophrenia, and other conditions.

Scientific Breakthrough Could Lead to Better Antipsychotic Drugs - Read More…

UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State

UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State

The lab of Jean Cook, PhD, joint professor in the department of pharmacology, found how a chain of proteins called an MCM complex could enable the fast cell-division that makes some forms of cancer so dangerous.

UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State - Read More…

Scientists Take a Big Step toward Building a Better Opioid

Scientists Take a Big Step toward Building a Better Opioid

In a paper published in Cell, research led by Bryan Roth, MD, PhD, and Roth lab members, Tao Ch, PhD and Daniel Wacker, PhD, show how to activate only one kind of brain receptor vital for pain relief. This receptor is not involved in addiction or respiratory depression that leads to death – the most severe side effects of opioid use.

Scientists Take a Big Step toward Building a Better Opioid - Read More…

UNC School of Medicine to Launch Computational Medicine Program

UNC School of Medicine to Launch Computational Medicine Program

Led by Timothy Elston, PhD, and Chuck Perou, PhD, the university-wide program aims to advance personalized medicine for patients.

UNC School of Medicine to Launch Computational Medicine Program - Read More…

A microscope maker

A microscope maker

Wesley Legant, PhD, Assistant Professor in Pharmacology, is highlighted in a Nature article on a do-it-yourself approach to microscopy that lead to the development of light sheet microscopy.

A microscope maker - Read More…

NIH renews grant funding the Bowles Alcohol Research Center

NIH renews grant funding the Bowles Alcohol Research Center

The center, established 20 years ago and led by Fulton Crews, PhD, Distinguished Professor in Pharmacology, will receive more than $8.7 million over five years to continue research on the effects of alcohol on the brain. Other pharmacology faculty who are PIs on the the grant are Clyde Hodge, PhD, Zoe McElligott, PhD, Tom Kash, PhD, Melissa Herman, PhD and Leslie Morrow, PhD.

NIH renews grant funding the Bowles Alcohol Research Center - Read More…

How do adult brain circuits regulate new neuron production?

How do adult brain circuits regulate new neuron production?

In a new study published in Cell Stem Cell, UNC School of Medicine neuroscientist Juan Song and colleagues discovered a long-distance brain circuit that controls the production of new neurons in the hippocampus.

How do adult brain circuits regulate new neuron production? - Read More…

Brian Jensen Receives The Hyman Battle Distinguished Excellence in Teaching Award and Delivers Whitehead Lecture

Brian Jensen Receives The Hyman Battle Distinguished Excellence in Teaching Award and Delivers Whitehead Lecture

Brian Jensen, MD, assistant professor of medicine and pharmacology, delivered the 2017 Whitehead Lecture. The event, which serves as an unofficial convocation of the UNC School of Medicine, has been held annually since 1947.

Brian Jensen Receives The Hyman Battle Distinguished Excellence in Teaching Award and Delivers Whitehead Lecture - Read More…