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A. Leslie Morrow, Ph.D.Associate Director
Bowles Center for Alcohol Studies

John Andrews Distinguished Professor
Departments of Psychiatry and Pharmacology

Member
UNC Neuroscience Center, Curriculum in Neurobiology, and Curriculum in Toxicology

Office | 3027 Thurston-Bowles Bldg, CB #7178
Email | morrow@med.unc.edu
Lab Website | Molecular Neuropharmacology

Biosketch | Morrow Biosketch

Research Interests

Mechanisms of Addiction Pathogenesis: The major goal of this project is to determine GABAergic cortolimbic circuit mechanisms of alcohol addiction. This project will examine the overall hypothesis that chronic ethanol exposure alters local mPFC and amygdalar microcircuits as well as the mPFC projection to central amygdala in conjunction with GABA-A receptor adaptations that can be prevented by histone acetylation.

Gene Delivery of Neuroactive Steroids to Modulate Ethanol Reinforcement/Consumption: The goal of this project is to evaluate the hypotheses that elevated steroidogenesis in the ventral tegmental area will reduce operant ethanol self-administration and the escalation of voluntary drinking following deprivation in male and female rats.

Recent Publications

Click here for a full list of publications from PubMed