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Adjunct Assistant Professor of Pharmacology, Joint with Biochemistry and Biophysics
Dominguez lab website

Research:

The Dominguez lab studies how gene expression is controlled by proteins that bind RNA. RNA binding proteins control the way RNAs are transcribed, spliced, polyadenylated, exported, degraded, and translated. Molecular Therapeutics

Area of Interest:

The Dominguez lab studies how gene expression is controlled by proteins that bind RNA. RNA binding proteins control the way RNAs are transcribed, spliced, polyadenylated, exported, degraded, and translated.
I use various high-throughput binding assays combined with in-cell approaches to i) study the RNA specificity of unconventional RNA binding domains made up of low-complexity amino acid sequences; ii) determine how disease-associated RBPs (that are frequently mutated) differentially interact with cellular targets. The proposed research combines my expertise from all stages of my career thus far and allow me to test questions that I am uniquely qualified to study and that differ from that of my previous mentors. Overall, with this approach, I expect to be able to explore answers to important questions such as i) how is the cellular transcriptome regulated? ii) What are basic mechanisms of RNA-protein interactions? iii) How do specific interactions between RNAs and proteins regulate cellular processes in normal and pathogenic settings?

Publications

(Click link above to view all publications)

Location:

Lab: 4023 F/G Genetic Medicine
120 Mason Farm
Chapel Hill, NC 27514

Office: 4113 Genetic Medicine
120 Mason Farm
Chapel Hill, NC 27514

Daniel Dominguez