Matthew Redinbo

Research: Structural basis of drug and DNA metabolism

Professor of Chemistry, UNC-CH

Professor of Biochemistry and Biophysics
Professor of Microbiology and Immunology
Director of Structural Biology
Member of Program in Molecular Biology and Biotechnology
Member of the Lineberger Comprehensive Cancer Center

PhD – University of California, Los Angeles


  • UNC Tanner Award for Excellence in Undergraduate teaching, 2019
  • UNC Research Outstanding Mentor Award, 2018
  • Fellow, AAAS, 2013
  • Academic Leadership Fellow, UNC, 2011
  • Academic Leadership Fellow, 2010
  • Phillip and Ruth Hettleman Prize for Artistic and Scholarly Achievement, 2004
  • Burroughs Wellcome Career Award in the Biomedical Sciences, 1999



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The focus of the Redinbo Lab is the examination of the structural and functional basis of cellular function with an eye toward human health. Current projects include discovery and development of drugs that improve chemotherapeutic efficacy for cancer and other diseases, and elucidation of the mechanisms of antibiotic resistance propagation in infectious pathogens. Basic science goals include understanding DNA manipulation and processing, transcription, and protein function during infection and disease.

Core Techniques:

Structural biology, chemical biology, biochemistry, molecular biology, microbiology, cell biology, drug discovery.

REPRESENTATIVE PUBLICATIONS PubMed(click for Full Publication List)

  • Wallace, B.D., Wang, H., Lane, K.T., Scott, J.E., Orans, J., Koo, J.S., Venkatesh, M., Jobin, C., Yeh, L.-A., Mani, S., and Redinbo, M.R.(2010). Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science, 330, 831-835.
  • Orans, J., Johnson, M.D.L., Coggan, K.A., Sperlazza, J.R., Heiniger, R.W., Wolfgang, M.C., and Redinbo, M.R. (2010). Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility.Proceedings of the National Academy of Sciences USA, 107, 1065-1070.

Lab Contact:

Lab Rooms: Genome 4350
Lab Fax: 919-962-2388